- Thread starter
- #201
Biological politics of statins link to Bolsonaro’s declaration of having antibodies against COVID-19. It is unknown whether statins assist, as in vaccines, in producing antibodies to C-19. However, other antibodies come into view as linking to why some people cannot tolerate cholesterol-lowering statins.
Firstly, cholesterol-lowering statins link to PCSK9.
PCSK9 Antibodies / Statins
https:// www.ncbi.nlm.nih.gov/pubmed/28618994
’....A large number of patients who need a statin are not receiving it.’
COVID-19 / PCSK9
’....Glende et al showed that cholesterol-rich membrane microdomains facilitated interaction between the surface glycoprotein S of SARS-CoV and the cellular receptor, ACE2....It is known that statin is the first lipid lowering choice in clinical practice and acts by inhibiting HMGCR.
....
Soto-Acosta et al showed a high amount of cellular cholesterol correlated with increased activity of the 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) during RNA virus infection....Statins and PCSK9 inhibitors may be useful to decreased cardiovascular risk and interfere with COVID-19 in FH (familial hype cholesterolemia) subjects.’
Firstly, cholesterol-lowering statins link to PCSK9.
PCSK9 Antibodies / Statins
https:// www.ncbi.nlm.nih.gov/pubmed/28618994
’....A large number of patients who need a statin are not receiving it.’
COVID-19 / PCSK9
May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects? - PubMed
May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects?
www.ncbi.nlm.nih.gov
....
Soto-Acosta et al showed a high amount of cellular cholesterol correlated with increased activity of the 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) during RNA virus infection....Statins and PCSK9 inhibitors may be useful to decreased cardiovascular risk and interfere with COVID-19 in FH (familial hype cholesterolemia) subjects.’