COVID-19’s Biological Politics

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badger2

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Biological politics of statins link to Bolsonaro’s declaration of having antibodies against COVID-19. It is unknown whether statins assist, as in vaccines, in producing antibodies to C-19. However, other antibodies come into view as linking to why some people cannot tolerate cholesterol-lowering statins.

Firstly, cholesterol-lowering statins link to PCSK9.

PCSK9 Antibodies / Statins
https:// www.ncbi.nlm.nih.gov/pubmed/28618994
’....A large number of patients who need a statin are not receiving it.’

COVID-19 / PCSK9
’....Glende et al showed that cholesterol-rich membrane microdomains facilitated interaction between the surface glycoprotein S of SARS-CoV and the cellular receptor, ACE2....It is known that statin is the first lipid lowering choice in clinical practice and acts by inhibiting HMGCR.
....
Soto-Acosta et al showed a high amount of cellular cholesterol correlated with increased activity of the 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) during RNA virus infection....Statins and PCSK9 inhibitors may be useful to decreased cardiovascular risk and interfere with COVID-19 in FH (familial hype cholesterolemia) subjects.’
 
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badger2

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What maybe a clue as to the 1.2 times infectivity rate of C-19 in blacks vs others, is found in a report from St. Louis linking melanocytes to another N-to-Y mutation:

St. Louis Asparagine-to-Tyrosine / Melancocyte / MITF
’....zebrafish ortholog MITF, microphtohalmia-associated transcription factor....absolutely required for neural crest melanocytes....a single base-pair change producing an asparagine to tyrosine amino acid substitution in the DNA-binding domain.’

We are now investigating connections between institutions in China cor these reports. The one on post #195 of this thread, is included:

’....mice....N501Y....’

Feb 2018 China Vertical Transmission of Zika / Mouse Offspring / Microphthalmia
’....aside from microcephaly and hippocampal dysplasia, eye abnormalities, including microphthalmia, thinner optic nerve, damaged retinae, and deficient visual projection....we first observed that ZIKV infection was inhibited by hydroxychloroquine and NH4Cl, indicating a requirement of low intracellular pH.’

These are the fundamental links to investigate for the N501Y trajectory in COVID-19 biology.
 
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So, even though a Pubmed search, ‘COVID-19 microphthalmia’ yields no references, links are found when one tracks the N501Y mutation more deeply into the arcana.
 
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Racial disparities in C-19 infection implicate melanocytes:

COVID-19 / Melanocytes / Mortality Rates
https:// www.ncbi.nlm.nih.gov/pubmed/32473354
’....In some cases, melanogenesis can directly impact the immune system through DC activation. Melanocytes are antigen-presenting cells and play a dynamic roles in the immune system....We previously described that firbromodulin (FMOD), a pigment-dependent angiogenic factor secreted by melanocytes, leads to proliferation of endothelial cells, followed by an increase in TGFbeta1 levels....Strikingly, induced DCs in the spleen were more numerous and mature in pigmented Black-C57 mice than in their under-melaninated congenic Yellow-C57 mice counterparts....black individuals may have the tendency to develop a harsher pro-inflammatory cytokine response.’
 
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Thusfar having found few connections between coronavirus and CD46, the latter links to measles vaccine strains and another asparagine-to-tyrosine substitution.

2001 Denmark Measles CD46 Substitution
’....Adaption to CD46 receptor usage was coupled to substitution of amino acid 481 of the MV H protein from asparagine to tyrosine but not to CD46 downregulation....a similar mechanism acted on the progenitor viruses of the present MV vaccine strains during their isolation and attenuation.’
 
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badger2

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This informative video about the new strain is from one day ago:

New COVID-19 Strain: What We Know So Far
 
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The new C-19 strain, N501Y is now in the United States, and bodes dangerous for older tobacco/marijuana smokers in Denver.

Colorado Confirms First Known US Case of New COVID-19 Strain Believed to Be More Contagious
’....Elbert County, outside of Denver....’
 
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At Coronavirus Pandemic Community Forum (aka Avian Flu Talk), they still don’t know that the N501Y C-19 mutation originated in Chinese mice in China, nor that the same mutation occurs in Alzheimer’s presenilin protein and the MITF gene linking melanocyte biology.
 
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A survey asking whether or not the Chinese know the C-19 source in nature would be interesting, because these authors attempt to separate humans from nature while simultaneously assuming it’s going to be just another haul-the-nets-in day, whilst whistling, unvaccinated Chinese fishermen play C-19 roulette with their genomes:

COVID-19’s Impact on Nature Through the Lens of Fisheries
’....On the other hand, this pandemic is also an opportunity for us to recognize how much humans are negatively impacting the natural world and how quickly some things can rebound if only we find ways to lay off and utilize them more sustainably.’

So, is a conservation program in, for example, China, to proceed to increase population numbers when the C-19 source is unknown? This is roulette par excellence: unwittingly increase the population of the intermediate host/reservoir of COVID-19 in nature.
 

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New covid rule in CA...if an ambulance is sent to your home and they can't find a pulse they are not allowed to transport you to the hospital...they must leave you to die....they used to take you in and try and revive you but not any longer...covid rule or money saver?....see folks?...no one gives a shit about you but you...don't ever forget that...and you can bet your ass if Newsome collapsed and they couldn't get a pulse they would take him to the ER immediately...

Enjoy CA dems.....enjoy the sewer vermin you voted for....
 
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Rock Bottom: China virus, China Joe, Chinese fentanyl.
 
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Japan has found the N501Y as well as another variant:

11 Jan 2021 Wall Street Journal, Japan Finds New COVID-19 Variant in Travelers from Brazil
’....E484K....’
 
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We’ve toured this facility in Wisconsin where recent tests show that big brown bats are not susceptible to COVID-19 infection. They could spend years testing every animal, though what needs to happen for this study to be more scientific is ACE2 amino acid sequence of big brown bats compared with the ACE2 sequence of the closest (published) animal to COVID-19, Rhinolophus affinis, let alone thiamine metabolism, etc. studies between them.


This Madison facility used to sport insect displays confiscated from the world animal trade, so pangolin/C-19 studies published recently are timely sequelae of this bat report.
 
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The problematic with the Madison facility (above) testing Big Brown Bat, Eptesicus fuscus, is that the Microchiroptera diverge into two branches Yangochiroptera (which includes E. Fuscus) and Rhinolophoidea (which includes the closest bat isolate to C-19, Rhinolophus affinis). Because thiamine has been brought up on other USMB threads, we here link the Little Brown Bat to thiamine and C-19.

Firstly, it’s important to note that bats were in hibernation at the time of the C-19 outbreak in Wuhan:

Dec 2020 Bats in Hibernation
’....Considering that bats were in hibernation when the outbreak occurred, and the phylogenetic resemblance of pangolin CoV strain to SARS-CoV-2, suggests that the virus is more likely to have been transmitted via other species. This also suggests the possible occurrence of recombination from pangolin and bats might have led to the origin of SARS-CoV-2 and the COVID-19 outbreak.’

Little Brown Bats / Hibernation / Thiamine Pyrophosphate

COVID-19 / Immune Storm Syndrome / Neurological Symptoms / Thiamine
’....Countering the cytokine storm with thiamine may have therapeutic efficacy. The Th-17-mediated IL-17 proinflammatory response can potentially be attenuated by thiamine.‘

Bats may use brain thiamine pyrophosphate during dormancy in the same manner that the antibiotic, deoxynojirimycin, is produced in Morus twigs at first frost.
 
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Tokyo reports today on a potentially critical COVID-19 situation:


14 Jan 2021 Japan Times, Tokyo Reports 1,502 New COVID-19 Cases as ‘Explosive Expansion’ Feared
‘....recent rise in cases in which infection routes cannot be traced is indicating an “explosive expansion” of infections....’

explosive expansion ‘bakuhatsuteki kakudai’ 爆発的かくだい。
 
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Three more regions in Japan are added to the ones above:

15 Jan 2021 Asahi Shimbun, Indicators Point to State of Emergency For 3 More Prefectures
’....A stage 4 designation indicates an “explosion” of new COVID-19 cases and that a state of emergency should be seriously considered....”The situation was made worse because it did not take seriously the scientific basis for what was occurring and placed greater emphasis on economic activity....half the blame must go to the general public....and allowed infections to spread through various opportunities to wine and dine.” ‘
 
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For a country that knows more about COVID-19 epidemiology in nature than any other country, it’s not that surprising that China rises economically:

15 Jan 2021 Japan Times, A Year After COVID-19 Began, China’s Economy is Beating the World
‘....”And really, the only marketplace where we’ve seen continued sort of trajectory in terms of managing the virus has been China.” ‘
 

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