COVID-19’s Biological Politics

[badger2]

Noting here that there is not the first example of the original Chinese Wuhan lab communication shown in the article so that others may analyze it themselves:

COVID-19 Origins: Investigating a “Complex and Grave Situation” Inside a Wuhan Lab

The Wuhan lab at the center of suspicions about the pandemic’s onset was far more troubled than known, documents unearthed by a Senate team reveal. Tracing the evidence, Vanity Fair and ProPublica give the clearest view yet of a biocomplex in crisis.

www.propublica.org

 

[badger2]

Quay @ 6h

https://twitter.com/Quay_dr

'...."My Line 2 COVID Conduit Hypothesis....And where I grew up, if your government asked for help, you gave it." '

 

[badger2]

Even though JFK Jr. has mentioned MI6 in his book, The Real Anthony Fauci, the irony may be that JKF Jr. has not read Sorensen, et al's paper and Quay doesn't seem to have read it, either. Be sure the CIA has read Quay's Line 2 Hypothesis.

The Fight for a Controversial Article

The fight for a controversial article

Birger Sørensen and Angus Dalgleish failed to get an article about the origins of the coronavirus published in a scientific journal. The authors suspect foul play and political considerations. Not everything gets published, is the answer from the journals. Minerva has obtained a draft of the...

www.minervanett.no

'....If such findings were confirmed, there could be political ramifications. Naturally, therefore, Sorensen, Dalgleish, and their unpublished paper have been mired in controversy ever since Sir Richard Dearlove, former head of MI6, endorsed their conclusions.'

 

[badger2]

Fau Chi got the SARS-CoV-2 mutation backwards in his video, a mutation that precisely links to ebola vaccine, as we have already shown on this thread: D614G. What does Fau know about amino acid changes in this strain of ebola? :

https://www.doctorswithoutborders.ca/article/there's-no-vaccine-available-ebola-outbreak-uganda---even-though-one-has-been-sitting-shelf

;....There are no approved vaccines or treatments for this species of ebola, which is the less common Ebola-Sudan type.'

 

[badger2]

The article is available on Potet's page, 28 Oct:

https://twitter.com/julienpotet

 

[badger2]

www.promedmail.org
'29 Oct 2022 Uganda Vaccine Trial....3 Sudan Ebola vaccines are from Oxford University in the UK and Sabin Vaccine Institute and Merck in the U.S.....outbreak epicenter is still Mubende and Kassanda districts.'

 

[badger2]

COVID
www.promedmail.org
'27 Oct 2022 Cardiac events: 118 times greater risk of death.'

 

[badger2]

@3h

https://twitter.com/WashburneAlex

'....Docs show Facebook and Twitter closely collaborating with Dept of Homeland Security, FBI to police "disinfo." Plans to expand censorship on topics like withdrawal from Afghanistan, origins of COVID, info that undermines confidence in financial institutions....SARS-CoV-2 did not leave a trail of infections along the route of animal trade.'

 

[badger2]

@3h

https://twitter.com/BallouxFrancois

'....The distribution of the (restriction) sites can be explained by the extensive genetic recombination between viral lineage and does not provide evidence for a lab origin of SARS-CoV-2.'

 

[badger2]

Biological Politics: Dr. McCullough's Crucifixion

https://twitter.com/chrisprcas

@ 30 Oct: McCullough: "Yesterday I was stripped of my board certifications in Internal Medicine and cardiology after decades of perfect clinical performance, board scores and hundreds of peer-reviewed publications. None of this will stop until there is a needle in every arm."

(also, scroll down to ) Hans Mahncke for the Daszak video.'


Pertinent posts to the lab-origin hypothesis:

https://twitter.com/tony_vandongen

30 Oct: An additional cleavage site was discovered in the SARS-CoV-2 spike protein. So it can be cleaved by two proteases, furin and cathepsin. This has implication for vaccines since cathepsin cleavage would release a small soluble peptide containing the 3 HIV-1 homology regions.
....
Oct 29 Big boi: Zoonot forces in disarray. Holmes, Fauci, Koopman withdraw in haste. Andersen, Rasmussen, Neil mount a desperate and brave last stand.
....
29 Oct Tony Vandongen: Could the 3 BsmBl and Bsal sites have been introduced into SARS-CoV-2 by recombination with other viruses? Certainly. There is only one slight problem with that scenario: it introduces up to 28 spurious sites that need to be removed by silent point mutations.'

 

[badger2]

The cathepsin article that Vandongen mentions (post # 1,290) is below. Again, furin-independent cathepsin cleavage links to Anthony Fau Chi's video mistake for the SARS-CoV-2 mutation, D614G, for ebola vaccine based on the vesicular stomatitis virus t that spike position, noting the proximity of Omicron's vaccine-linked mutation, N969K, to the second cathepsin cleavage site:

China: Novel Cleavage Sites Identified in SARS-CoV-2 Spike Protein Reveal Mechanism for Cathepsin L-Facilitated Viral Infection and Treatment Strategies

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies - PubMed

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence of variant strains with mutated S proteins has rendered many treatments ineffective. Cleavage of the S protein by host...

pubmed.ncbi.nlm.nih.gov

'....In contrast, our newly identified CTSL cleavage sites in S protein are highly conserved in SARS-CoV-2 variants, including the recently emerged Omicron variant, suggesting these CTSL cleavage sites may be essential for the SARS-CoV-2 life cycle.
....
CTSL Inhibitors Prevent SARS-CoV-2 Infection

It seems that CTSL inhibitors are most likely resistant to mutational escape of SARS-CoV-2, including Omicron and Beta variants....Neither of the compounds inhibited vesicle stomatitis virus (VSV) infection, indicating that the inhibitory effects of CTSL inhibitors depend on SARS-CoV-2 S protein.'

 

[badger2]

The Chinese article continues:
'....with proline substitutions at K986 and V987 and a "GSAS" substitution at the furin cleavage site R682-R685.'

 

[badger2]

The N969K mutation in Omicron (BA.4) arose in South Africa. Details will likely remain esoteric. This is a stabilizing mutation (vs destabilizing mutation):

N969K

The rapid emergence of multiple sublineages of Omicron (B.1.1.529) variant: Dynamic profiling via molecular phylogenetics and mutational landscape studies - PubMed

Our molecular phylogenetic studies provided a deeper understanding of the microevolution of sublineages and the creation of Omicron. Similarly, this study might help scientists develop pan-coronavirus vaccines that consider their mutational properties.

pubmed.ncbi.nlm.nih.gov

'N969K is a stabilizing mutation.'

Since we have already posted some N/K associations recently in this thread.

N969K occurs in the HR1 region, and we've already mentioned that HR1 is a vaccine-related region, used to stabilize the protein for vaccine production.

Sep 2022 Francis Crick Institute, London and Ulm, Germany

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2 - PubMed

SARS-CoV-2 Omicron rapidly outcompeted other variants and currently dominates the COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be driven by numerous mutations in the Omicron Spike protein. Here, we systematically introduced BA.1 and/or BA.2 Omicron Spike...

pubmed.ncbi.nlm.nih.gov

'....Individual mutations of S371F/L, S375F, and T376A in the ACE2 receptor-binding domain RBD) as well as Q954H and N969K in the hinge region 1 (HR1, heptad repeat region 1) impaired infectivity, while changes to G339D, D614G, N764K, and L981F moderately enhanced it.
....
Our results represent a systematic functional analysis of Omicron spike adaptions that have allowed this SARS-CoV-2 variant to dominate the current pandemic.'

The virus mutating from asparagine (N) to lysine (K) at position 969 was reacting in the first human host of Omicron BA.4 at precisely a vaccine-related location.

 

[badger2]

Abov, "Fau Chi's Mutation," D614G, causes Omicron's enhanced infectivity. This precise mutation in SARS-CoV-2 links to VSV-based ebola vaccine, as we've already posted to this thread.

 

[badger2]

Cathepsin: Trump Was Correct

Post # 1,291 links cathepsin L to SARS-CoV-2 and its inhibitors. Here is shown the difference between cathepsin inhibitors and the cathepsin L link to ebola, underscoring the relevance of SARS-CoV-2 mutation, "Fau Chi's Mutation," to ebola vaccine:

Feb 2010 Mt. Sinai, New York / Ebola Cathepsin L

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition - PubMed

Cathepsins B and L contribute to Ebola virus (EBOV) entry into Vero cells and mouse embryonic fibroblasts. However, the role of cathepsins in EBOV-infection of human dendritic cells (DCs), important targets of infection in vivo, remains undefined. Here, EBOV-like particles containing a...

pubmed.ncbi.nlm.nih.gov

'....While dendritic cell infection is blocked by cathepsin B inhibitor, it is insensitive to cathepsin L inhibitor.'

Thus, comparison between B and L structures will yield clues to the mechanism of action occurring for these two viruses.

Also, Trump was correct about hydroxychloroquine against cathepsin L-mediated virus entry by SARS-CoV-2, as the abstract posted here documents:

18 Aug 2022 Post #1,122

COVID-19’s Biological Politics

This is an airborne or surface phenomenon: Non-Sexual Monkeypox: UK to Stanford, Ca. https://wwwnc.cdc.gov/eid/article/28/10/22-1191_article Seems a surface phenomenon: dog petting/e-cigarette....'and was taking HIV preexposure prophylaxis.' That's enough to prompt more rigorous investigation...

www.usmessageboard.com

'....Hydroxychloroquine efficiently blocks viral entry mediated by cathepsin L, but not by TMPRSS2, and that a combination of hydroxychloroquine and a clinically tested TMPRSS2 inhibitor prevents SARS-CoV-2 infection more potently than either drug alone.'

 

[badger2]

1 Nov 2022 Open Letter to Elon Musk on Origins of COVID

https://twitter.com/hashtag/OriginsofCovid

 

[badger2]

Parkinson's Connection: Breakfast Dogs Studies the ZC45 Sequences.

We have already mentioned the Parkinson's RGD sequence link to bat Cov ZC45 RGD sequence in this thread. This RGD motif is a different critter compared to the FCS (furin cleavage site), but does link to affinity for tissues.

Breakfast Dogs

https://twitter.com/breakfast_dogs

28 Oct: ' But after the outbreak, now Major General Wuchun Cao set out to find other viruses that would divert attention from the close relationship of ZC45 and SARS-CoV-2. While Zhengli Shi provided RaTG13, he contributed the pangolin sequences.'

Putin's KGB knew about ZC45 at least as early as Jan 2021, though more likely since 2017, when ZC45 was found by the Chinese military on Zhoushan Island, Zhejiang Province, China. ZC45 is neurotropic in rats, making the Parkinson's connection to neurons.

As will be shown, rather than a gain-of-function phenotype, the RGD sequence links to a gain-of-susceptibility phenotype.

 

[badger2]

Jan 2021 Universite du Quebec a Montreal / Vladimir Makarenkov, et al / ZC45

Horizontal gene transfer and recombination analysis of SARS-CoV-2 genes helps discover its close relatives and shed light on its origin - PubMed

The results of our horizontal gene transfer and recombination analysis suggest that SARS-CoV-2 could not only be a chimera virus resulting from recombination of the bat RaTG13 and Guangdong pangolin coronaviruses but also a close relative of the bat CoV ZC45 and ZXC21 strains. They also indicate...

pubmed.ncbi.nlm.nih.gov

'....but also a close relative of the bat CoV ZC45 and ZXC21 strains.'

 

[badger2]

Breakfast Dogs (post # 1, 297) states @ 12 Oct: 'If ZC45 is part of a newly discovered natural clade, why does it also have some features of the original SARS-like viruses? It seems to be the missing link between SARS-1 and SARS-2, and deserves far more attention than it gets.'

 

[CrusaderFrank]

Cathepsin: Trump Was Correct

Post # 1,291 links cathepsin L to SARS-CoV-2 and its inhibitors. Here is shown the difference between cathepsin inhibitors and the cathepsin L link to ebola, underscoring the relevance of SARS-CoV-2 mutation, "Fau Chi's Mutation," to ebola vaccine:

Feb 2010 Mt. Sinai, New York / Ebola Cathepsin L

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition - PubMed

Cathepsins B and L contribute to Ebola virus (EBOV) entry into Vero cells and mouse embryonic fibroblasts. However, the role of cathepsins in EBOV-infection of human dendritic cells (DCs), important targets of infection in vivo, remains undefined. Here, EBOV-like particles containing a...

pubmed.ncbi.nlm.nih.gov

'....While dendritic cell infection is blocked by cathepsin B inhibitor, it is insensitive to cathepsin L inhibitor.'

Thus, comparison between B and L structures will yield clues to the mechanism of action occurring for these two viruses.

Also, Trump was correct about hydroxychloroquine against cathepsin L-mediated virus entry by SARS-CoV-2, as the abstract posted here documents:

18 Aug 2022 Post #1,122

COVID-19’s Biological Politics

This is an airborne or surface phenomenon: Non-Sexual Monkeypox: UK to Stanford, Ca. https://wwwnc.cdc.gov/eid/article/28/10/22-1191_article Seems a surface phenomenon: dog petting/e-cigarette....'and was taking HIV preexposure prophylaxis.' That's enough to prompt more rigorous investigation...

www.usmessageboard.com

'....Hydroxychloroquine efficiently blocks viral entry mediated by cathepsin L, but not by TMPRSS2, and that a combination of hydroxychloroquine and a clinically tested TMPRSS2 inhibitor prevents SARS-CoV-2 infection more potently than either drug alone.'

SMH

"...Hydroxychloroquine efficiently blocks viral entry mediated by cathepsin L, but not by TMPRSS2, and that a combination of hydroxychloroquine and a clinically tested TMPRSS2 inhibitor prevents SARS-CoV-2 infection more potently than either drug alone.'

Amazing