COVID-19’s Biological Politics

[badger2]

We link cannabis to androgen receptors, then to SARS-CoV-2:

1980 Cannabis / Androgen Receptors

Marihuana inhibits dihydrotestosterone binding to the androgen receptor - PubMed

Marihuana and its constitutents delta 9-tetrahydrocannabinol (delta 9-THC) and cannabinol (CBN) were tested for their ability to interact with the androgen receptor in rat prostate cytosol. Smoked marihuana condensate, delta 9-THC, and CBN inhibit specific binding of dihydrotestosterone (DHT) to...

pubmed.ncbi.nlm.nih.gov

Some may wish to boycott the effeminzing cannabis cartoon due to the following assumption from an Italian study:

Jan 2021 Italy: Low Testosterone / Gonadal Function / COVID-19

Worse progression of COVID-19 in men: Is testosterone a key factor? - PubMed

T in comparison to estrogen may predispose men to a widespread COVID-19 infection. Low serum levels of T, which should be supposed to characterize the hormonal milieu in seriously ill individuals, may predispose men, especially elderly men, to poor prognosis or death. Further studies are needed...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

It is unknown just when the CDC sanitized their webpage and removed the asparagine that the virus was alternating with threonine at position 417 of the Brazil-Japan variant, P.1. Nevertheless, Brazil leads the world in the number of current deaths within the last 7 days:

Pandemic Worldometer

COVID-19 Weekly Trends by Country - Worldometer

New cases and deaths in the last 7 days vs. the preceding week. Absolute and percentage change, weekly cases and deaths per million people in every country in the world

www.worldometers.info

’....Brazil 9, 071....’

The P.1 variant has no deletions such as those found in Delta or Lambda:

L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I

Comparing variants, the virus changes its glutamic acid (E) in the Brazil variant @484, to lysine (E484K), though changes from leucine (L) to glutamine (Q) in the Lambda variant (L452Q). California and Delta variants contain the leucine-to-arginine (L452R) mutation.

 

[badger2]

Note that the T20N in the P.1 variant compares with the original CDC webpage entry for the variant, K471T/N, which was changed to K417T by removing the asparagine (N). Thus, positions 20 and 417 of the spike protein reveal that indeed the virus has the ability to alternate between N and T at particular positions.

 

[badger2]

Post #583 should read ‘K417T/N’ rather than ‘K471T/N’ though that on CDC’s webpage was likely not a typo.

 

[badger2]

The feline infectious peritonitis virus (FIPV), mentioned above, at position 1273 is an asparagine (N), and position 1273 of SARS-CoV-2 is (T), threonine. The vaccine was named mRNA-1273 because it is the last amino acid in SARS-CoV-2 spike protein.

 

[badger2]

It should be mentioned that the feline coronavirus, FIPV spike @N1273 differs from two other human coronaviruses by only one atom. Both HCov-NL-63 and NCoV-229E have D1273, aspartic acid. The isoelectric point of the feline virus (N) is 5.41, both human isoelectric points = 2.77, the lowest of the amino acid pIs. This pole compares with R (arginine) the highest isoelectric poont of the amino acids, 10.76, which the virus substitutes in the Delta/California variants: L452R.

 

[badger2]

Long COVID in Middle-Aged Women: “I Can’t Walk 10m Without A Rest”

We’ll be comparing chikungunya virus to COVID-19 ‘Long COVID’ in middle-aged females, showing the connections to Alzheimer’s.

Long COVID

Long Covid: 'I can't walk 10m without a rest'

Three people tell the BBC how the condition has affected their physical and mental health.

www.bbc.com

Middle-Aged Women ‘Worst Affected By Long COVID,’ Studies Find

Middle-aged women 'worst affected by long Covid', studies find

Five months after hospital treatment, 70% of patients studied had still not fully recovered.

www.bbc.com

 

[badger2]

This time, Fau Chi is correct about COVID-19 vaccinations, though has never mentioned the horses. Both Chikungunya and EEEV are alphaviruses:

From Promedmail, 11 Jul 2021 EEEV / Horses / Florida Panhandle
(Source: Outbreak News Today)

Eastern Equine Encephalitis reach a dozen in Florida horses - Outbreak News Today

By NewsDesk @infectiousdiseasenews Florida agriculture officials reported the 11th and 12th equid Eastern Equine Encephalitis (EEE) cases this year in the state. The latest cases are from Bay County and Jefferson County, both counties in the Florida panhandle. Both horses are alive and were...

outbreaknewstoday.com

‘....Florida Panhandle....both horses were alive and were undervaccinated....’

While tracking the 2007 chikungunya outbreak to Italy and its proximity to COVID-19 in the Lombardy clusters, mention was made of EEEV, on 23 Feb 2020 in the snake meat thread:

Post #491, 23 Feb 2020

Snake Meat......source of chinese virus

In post #478 we noted dephosphorylation and phosphorylation sites linked to Homo sapiens HDAC1 and chloroquine, which full text we cannot access. In the Bologna COVID-19 study (post #313), the serine-to-leucine at position 84 of COVID-19 ORF8: 'We analyzed the alternative isoforms of COVID-19...

www.usmessageboard.com

Next, chikungunya in Yunnan links to Dazak and Eco Health Alliance at Dali, in the co-authored papers we have already mentioned in this thread:

May 2021 Emergent Chikungunya / Yunnan / Mother-To-Child (Vertical) Transmission

Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019 - PubMed

During the dengue epidemic in Yunnan Province, China, during 2019, a concurrent outbreak of chikungunya occurred in the city of Ruili, which is located in the southwest of the province, adjacent to Myanmar. As part of this outbreak, three neonatal cases of infection with indigenous chikungunya...

pubmed.ncbi.nlm.nih.gov

’....
1. Yunnan Institute of Endemic Diseases Control and Prevention, Dali, Yunnan

2. Center for Disease Control and Prevention of Southern Theater Command, Kunming, Yunnan....’

The mutations mentioned in post #491 of the snake meat thread for heparan sulfate and EEEV will be included in our comparisons between chikungunya and Long COVID.

 

[badger2]

We’ll link the alanine-to-valine Alzheimer’s-like mutation that arose on Reunion, to the Asian Tiger mosquito, which mosquito in Yunnan lacks the mutation, following this neurological link comparing chikungunya and COVID-19:

Long COVID / Chikungunya

Research priorities for Long Covid: refined through an international multi-stakeholder forum - PubMed

Research priorities for Long Covid: refined through an international multi-stakeholder forum

pubmed.ncbi.nlm.nih.gov

’....There are important similarities between CHIKV and COVID-19 including long-lasting and heterogeneous symptoms post-acute infection and research challenges, due to a lack of standardization of case definitions, study measures, and inclusion criteria.’

Once mutated, it took the chikungunya virus 1-2 years to reach Italy for the 2007 outbreak (near the COVID-19 outbreak epicenter in Lombardy). Compare E1 on Reunion Is. to E2 of EEEV (post #491, snake meat thread):

Reunion: Chikungunya Adaption to Secondary Vector / E1 A226V Mutation

Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak - PubMed

The unique molecular features of the analyzed Indian Ocean isolates of chikungunya virus demonstrate their high evolutionary potential and suggest possible clues for understanding the atypical magnitude and virulence of this outbreak.

pubmed.ncbi.nlm.nih.gov

’....CHIKV strains in the 2005-6 Reunion Is. outbreak incurred a mutation that facilitated transmission by the Asian Tiger mosquito, Aedes albopictus, E1 A226V, and potentially allows CHIKV to replicate more easily in mosquito cells.’

This A226V is the Alzheimer’s-like mutation, which alanine-to-valine is (age-related [italics]) in Alzheimer’s, thus underscoring more rigorous scrutiny of Long COVID in middle-aged women.

 

[badger2]

On emergent chikungunya in Yunnan, it’s obvious that if the Chinese knew about the lack of Alzheimer’s-like mutations in Yunnan CHIKV that caused transplacental transmisson, so too would Eco Health Alliance, New York. As the May 2021 Yunnan report in post #588 states: ‘E1 genes of these viruses did not harbor the A226V mutation.‘

On 1 Nov 2018 in the Evolution of the Saxophone thread, mention was made of various Japanese Alzheimer’s and Alzheimer’s-like mutations, including Zika virus:

Alanine-to-Valine, post #16

Evolution of the Saxophone

We first recall that John Coltrane's Both Directions at Once, Giant Steps, and others, are classics in the evolution of saxophone virtuosity. The Lost Album John Coltrane’s majestic 1963 session, Both Directions at Once, is discovered As the article states, Coltrane died of liver cancer. Many...

www.usmessageboard.com

‘....mean age of onset: 40.3 years....A260V....A285V had a later age of onset, mean 51 years, but a more rapid course....abundant perivascular subapial amyloid deposits in Virchow-Robin spaces and Pick-like intraneuronal inclusions.’

In post #314 of this thread was mentioned the Henri Mondor variant of COVID-19, the only (apparent) variant that sports two Alzheimer’s like mutations, A653V and N501Y.

May 2021 Marseille, France: A653V Mutation

Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage - PubMed

These findings warrant further studies to investigate the spread, epidemiological and clinical features, and sensitivity to immune responses of this variant.

pubmed.ncbi.nlm.nih.gov

’....A new set of amino acid substitutions, including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V,+/- Q677H....the 89 sequences obtained in our institution or other laboratories originated from the Comoros archipelago, western European countries (mostly metropolitan France), Turkey and Nigeria....’

 

[badger2]

A report on the situation in The Netherlands, and recently there have been four cases of the Lambda variant in Italy:

Avian Flu Talk

NL R0=2,17 !

https://nltimes.nl/2021/07/13/dutch-coronavirus-reproduction-level-reaches-worst-point-since-feb-2020...

www.avianflutalk.com

’....For the first time since the start of the pandemic, people in The Netherlands infected with SARS-CoV-2 were likely infecting at least two other people. The basic reproduction (R) number has swelled an estimated 2.17, said Aura Timen of the RIVM....was revealed by a technical briefing in Parliament....The average number of coronavirus infections has risen 10-fold....reproduction of the Delta variant in The Netherlands was factored at 2.52, Timen said. That means 100 contagious people infect 252 others who can then spread it to another 635 people when unchecked.’

4 Days Ago: Lambda in Italy

404. That’s an error.

Italy24 News English

www.italy24news.com

’....The Lambda variant has also been identified in Italy. Specifically, Lombardy, Piedmont, Emilia Rogmana, Lazio and Sicily have already identified....genetic sequences of this variant.’

 

[badger2]

The Delta variant is now dominant in New Jersey while the Lambda variant has not yet arisen in the U.S.

14 Jul 2021 Delta Now Dominant in New Jersey

Delta variant now dominant COVID strain in NJ

The Delta variant of COVID-19 is now the predominant strain in New Jersey, according to Governor Phil Murphy and health officials.

www.news.yahoo.com

 

[badger2]

Delta variant will likely dominate the COVID-19 world, and following, Porton Down authors are included in a 57-author study on variants. Porton Down is a serious UK installation:

3 Jul 2021 Delta to Dominate World

Delta to dominate world - PubMed

This surging variant of the coronavirus is on course to outcompete all the other versions of the virus globally, reports <b>Adam Vaughan</b>.

pubmed.ncbi.nlm.nih.gov

’....It’s going to lead to a great disruption and a large number of deaths in places where there isn’t much vaccine.’

Variants Study

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum - PubMed

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection...

pubmed.ncbi.nlm.nih.gov

’....Individuals infected previously by these variants may be more susceptible to reinfection by B.1.617.2 (Delta). This observation provides important new insights for immunization policy with future variant vaccines in non-immune populations.’

Furin cleavage sites have already been mentioned in various threads (USMB search):

13 Jul 2021 Germany, Bangladesh, Egypt / Furin Cleavage

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals - PubMed

The SARS-CoV-2 spike protein Q677P/H mutation and furin cleavage site (FCS) have been shown to affect cell tropism and virus transmissibility. Here, we analyzed the frequency of Q677P/H and FCS point mutations in 1,144,793 human and 1042 animal spike protein sequences and from those of the...

pubmed.ncbi.nlm.nih.gov

8 Jul 2021 Institute Pasteur, Paris / Delta Variant

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization - PubMed

The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India^1-5. Since then, it has become dominant in some regions of India and in the UK, and has spread to many other countries⁶. The lineage includes three main subtypes (B1.617.1, B.1.617.2 and B.1.617.3), which...

pubmed.ncbi.nlm.nih.gov

’....Sera from convalescent patients collected up to 12 months post symptoms were four-fold less potent against Delta.’

11 Jul 2021 Long COVID: “Like They Had Their Childhood Stolen”

âTheir childhood has been stolenâ: calls for action to tackle long Covid

MPs and peers demand review of debilitating condition as fears grow of surge among young after 19 July lifting

www.theguardian.com

’....wheelchairs....’

 

[badger2]

CDC variants page has recently added mutations to the Delta variant (1.617.2). One of them is an Alzheimer’s-like alanine-to-valine that was already mentioned in the Jun 2021, 57-author Porton Down study, above:

V70F (SARS-CoV is V70, HCoV-NL63 is V70, porcine TGEV is V70)

A222V (SARS-CoV is A222, feline FCOV is V222, canine CCoV is V222, and porcine TGEV is V222), so the SARS-CoV-2 virus mutates toward feline, canine, and porcine in this human mutation, respectively.

W258L (SARS-CoV is W258)

 

[badger2]

In comparison to the Alzheimer’s-like mutation A222V in SARS-CoV-2, next are examples in feline, canine, and porcine Alzheimer’s:

Dec 2020 Israel / The Netherlands / Feline Alzheimer’s / Cannabidiol

Feline cognitive dysfunction as a model for Alzheimer's disease in the research of CBD as a potential treatment-a narrative review - PubMed

With the improvement in modern medicine, the world's human and feline (Felis catus, the domestic cat) population is aging. As the population grows older, there is an increase of age-related diseases, such as Alzheimer's disease in humans and feline cognitive dysfunction in felines, which shares...

pubmed.ncbi.nlm.nih.gov

May 2019 Cornell / U. Of Florida / Canine Cognitive Dysfunction Alzheimer’s Analog

Canine Cognitive Dysfunction: Pathophysiology, Diagnosis, and Treatment - PubMed

Canine cognitive dysfunction (CCD) is the canine analog of human Alzheimer disease (AD). The pathophysiology of CCD/AD is multifaceted. CCD is common in aged (>8 years) dogs, affecting between 14% and 35% of the pet dog population. Apparent confusion, anxiety, disturbance of the sleep/wake cycle, …

pubmed.ncbi.nlm.nih.gov

Jan 2020 Hebei, China / Protective Porcine Cerebroside-Ganglioside

Neuroprotective effect of CPCGI on Alzheimer's disease and its mechanism - PubMed

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder causing progressive memory loss and cognitive impairment. The aberrant accumulation of amyloid‑β (Aβ) and neuroinflammation are two major events in AD. Aβ‑induced neurotoxicity and oxidative stress are also involved in the...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

Not a usual site, today two transplant vehicles were seen rolling along within one hour on different sides of town.

14 Jul 2021 24-Year-Old Double Lung Transplant

https://news.yahoo.com/24-year-old-who-needed-double-lung-transplant-wishes-hed-been-vaccinated-for-covid-19-1808810400.html

 

[badger2]

The title is “Hospitalized Man, 24, Has Message For Vaccine Skeptics.”

 

[badger2]

The P.1 Brazil-Japan variant has the L18F mutation, as does the Delta variant, though it is the Delta variant that yields a clue to Zika-induced microcephaly in Brazil: the Alzheimer’s-like alanine-to-valine mutation, A222V, recently added to the variants list by the CDC. This corresponds to Zika A175V, and also Saudi microcephaly:

PGAP2 / A64V / Microcephaly

A novel mutation in PGAP2 gene causes developmental delay, intellectual disability, epilepsy and microcephaly in consanguineous Saudi family - PubMed

PGAP2 (Post-GPI Attachment to Proteins 2) gene is involved in lipid remodeling steps of Glycosylphosphatidylinositol (GPI)-anchor maturation. At the surface of the cell this gene is required for proper expression of GPI-anchored proteins. Hyperphosphatasia with mental retardation syndrome-3 is...

pubmed.ncbi.nlm.nih.gov

 

[Rigby5]

A mutation implies a random event like radiation or something, and that would just result in being nonviable so often, that it takes millions of year for one to be lucky enough to actually survive.
But what makes new variants is not random mutations.
Instead, it is from more than one virus injecting its RNA into the same host cell nucleus.
The resulting combination is not really a mutation.
It is closer to the process of hybridization, even though asexual.

 

[badger2]

There is also an Alzheimer’s-like mutation in the South African variant, B.1.351: A701V.

SARS-CoV-2 / Alanine-to-Valine / Aminopeptidase N

Identification of six new polymorphisms in the human coronavirus 229E receptor gene (aminopeptidase N/CD13) - PubMed

These results demonstrate that there is a relatively broad spectrum of variations in the APN domain critical for coronavirus binding.

pubmed.ncbi.nlm.nih.gov

’....Apart from the codon 311 variation (C956T), none of the other associated polymorphisms has an apparent functional effect, as codon 318 and 321 variations (G978T and G987A) are silent, and C389T is located in an intron....The alanine to valine substitution in codon 311, caused by a single nucleotide polymorphism C956T is an amino acid change occurring in the APN (aminopeptidase N) domain that is essential for its HCoV-229E receptor function. This alanine to valine substitution, a conservative amino acid change, has already been described in a population of Italian coeliac disease patients, in which it was observed with an allele frequency of 7.9%. In our population, an equal frequency of 8.5%.’

Jan 2021 San Francisco: Aminopeptidase N / SARS-Cov-2

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses - PubMed

The Coronaviridae are a family of viruses that cause disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors common to multiple coronaviruses could facilitate the development of therapies to combat current and...

pubmed.ncbi.nlm.nih.gov

’....Additionally, we identified phosphatidylinositol phosphate biosynthesis and cholesterol homeostasis as critical host pathways supporting infection by all three coronaviruses.’