COVID-19’s Biological Politics

[badger2]

Because SARS-CoV-2 D614G (aspartic acid-to-glycine) mutation links precisely to the VSV of ebola vaccine, a Pubmed search ‘ebola aspartic glycine,’ yielded no references. Next, an ‘ebola mutations’ search yielded Niemann-Pick references, so a refined search was attempted: ‘Niemann-Pick aspartic glycine,’ which indeed retrieved a D-to-G mutation:

2011 Dartmouth Medical School, Niemann-Pick D1005G

A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations - PubMed

We have identified a point mutation in Npc1 that creates a novel mouse model (Npc1(nmf164)) of Niemann-Pick type C1 (NPC) disease: a single nucleotide change (A to G at cDNA bp 3163) that results in an aspartate to glycine change at position 1005 (D1005G). This change is in the cysteine-rich...

pubmed.ncbi.nlm.nih.gov

’This change is in the cysteine-rich luminal loop of the NPC1 protein and is highly similar to commonly occurring human mutations....late-onset, slowly progressing forms of NPC disease that comprise the large majority of cases.’

To verify a link to COVID-19, a search ‘cysteine-rich covid-19’ yielded a coagulopathy link:

Nov 2020 Rome: Cysteine-Rich Coagulopathy

New Consensus pattern in Spike CoV-2: potential implications in coagulation process and cell-cell fusion - PubMed

Coagulopathy and syncytial formation are relevant effects of the SARS-CoV-2 infection, but the underlying molecular mechanisms triggering these processes are not fully elucidated. Here, we identified a potential consensus pattern in the Spike S glycoprotein present within the cytoplasmic domain...

pubmed.ncbi.nlm.nih.gov

’....The pattern was present in both human and bat coronavirus S proteins....a positive role of cysteine palmitoylation in cell fusion has been reported for influenza virus HA proteins, while a negative role was observed for Vesicular Stomatitis virus (VSV)....Intriguingly, the CAF-motif occurs in proteins such as coagulation factor X, von Willebrand factor, platelet endothelial aggregation receptor 1, and some pro-thrombin activator venom toxins that are involved in the coagulation process. The identification of a common pattern could suggest a new function of the S protein in the pathological effects of SARS-CoV-2.’

 

[badger2]

The late-onset form of NPC disease, above, links to coagulopathy, and we have already mentioned coagulation factor XII in relation to Alzheimer’s disease in posts # 338-9 of this thread. It is thus interesting that the French Henri Mondor variant does not contain the D614G mutation, whilst it does contain two Alzheimer’s-like mutations.

18 Ap 2021 Posts #338 & 339

COVID-19’s Biological Politics

G910V Mutation in Ehlers-Danlos Syndrome / Cyanogen Bromide https://pubmed.ncbi.nlm.nih.gov/1895316 The L452R mutation in the Henri-Mondor variant also occurs in USA (California). We are tempted to suggest that this mutation occured in a Chinese-American Californian, because of the connection...

www.usmessageboard.com

’....Alzheimer’s fibrinogen blood coagulation system.’

Furthermore, the Mondor variant’s two Alzheimer-like mutations are N501Y, which we have already mentioned in this thread, and A653V. The latter Mondor mutation is similar to C-19’s A483V Alzheimer-like mutation, which can be compared with late-onset coagulopathy of NPC disease, because it causes early-onset Alzheimer’s from 26-36 years of age.

 

[badger2]

Then in post #340, Ft. Detrick studies were linked to hantavirus and coagulation factor XII:

Post #340

COVID-19’s Biological Politics

G910V Mutation in Ehlers-Danlos Syndrome / Cyanogen Bromide https://pubmed.ncbi.nlm.nih.gov/1895316 The L452R mutation in the Henri-Mondor variant also occurs in USA (California). We are tempted to suggest that this mutation occured in a Chinese-American Californian, because of the connection...

www.usmessageboard.com

 

[LordBrownTrout]

Fauci got a lotta explaining to do.

DOC #2286 [Bioweapon Recipe]


DOC DUMP ARCHIVES:
LEOPOLD NIH FOIA Anthony Fauci Emails – DocumentCloud

Zerohedge

ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero

www.zerohedge.com

La de da

"British professor Angus Dalgleish - best known for creating the world's first 'HIV vaccine', and Norwegian virologist Dr. Birger Sørensen - chair of pharmaceutical company, Immunor, who has published 31 peer-reviewed papers and holds several patents, wrote that while analyzing virus samples last year, the pair discovered "unique fingerprints" in the form of "six inserts" created through gain-of-function research at the Wuhan Institute of Virology in China."

 

[badger2]

Yes, LBT, we’d like to know about the inserts, because retroviral elements can naturally integrate into the coronavirus genome, without human manipulation. Fauci likely was involved in early HIV vaccine research, and all that Rand Paul has to do in public is to mention the D614G mutation, that precisely links to ebola vaccine.

Furthermore, Fort Detrick’s study on increased potency of the venom of one of the suspected hosts of SARS-CoV-2, Bungarus, is problematic, because a subspecies of this genus, B. wanghaotingi, has apparently not yet been sequenced. This subspecies may occur near to RaTG13. Thus, Bungarus as intermediate host of SARS-CoV-2 cannot yet be ruled out. One important thing to do is to document the precise geographical location of C-19’s closest relative, RaTG13, from Yunnan Province.

We mentioned Daszak’s work, which goes back to 2011, in conjunction with the nasty Kunming animal market, not the Wuhan seafood market, on 13 Feb 2020. Daszak is co-author of the second entry of post #404:

Post #404

Snake Meat......source of chinese virus

The Chinese eat badgers. Snakes Are The Likely Source of China's Deadly Coronavirus. Here's Why In the case of this 2019 coronavirus outbreak, reports state that most of the first group of patients hospitalized were workers or customers at a local seafood wholesale market which also sold...

www.usmessageboard.com

 

[badger2]

In the video, Fauci gets the 614 mutation backwards. This was surprising due to the fact that mutating to glycine seemed more primitive than mutating to an aspartic acid. Fauci mentions this D614G mutation, but never links it to ebola vaccine as we have done in this thread. Indeed, this D-to-G mutation occurs not only in HIV-1, but also HIV-2, which many consider to be an older virus. Fauci’s apparent “mistake” begins at timepoint 6:45 in the youtube video, and he makes a point to reify this mutation:

Fauci / D614G Mutation / Timepoint 6:45


2013: Osaka, Japan / TRIM HIV-1 Aspartic Acid to Glycine Substitution

A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection - PubMed

TRIM5α is a factor contributing to intracellular defense mechanisms against retrovirus infection. Rhesus and cynomolgus monkey TRIM5αs potently restrict HIV-1, whereas human TRIM5α shows weak effects against HIV-1. We investigated the association between a single nucleotide polymorphism in the...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

Note that in Fig.1 at position 249 in the TRIM5 report, above, the chart shows that African Green monkey is glycine (G) and human MT4 is aspartic acid (D), and that ‘ human TRIM5alpha with 249D may lose the flexibility required for optimal recognition of retroviral capsid protein.’

This is quite comparable with the COVID-19 D614G mutation found in the B.1.351 South Africa variant, P.1 Japan-Brazil, B.1.427 & B.1.429 California, and all Indian variants (B.1.617-B.1.617.3).

 

[badger2]

An Italian report is among the few linking TRIM5 with COVID-19:

Mar 2021 Italy: TRIM5 / COVID-19

Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants - PubMed

Germline variants in genes involved in SARS-CoV-2 cell entry and in host innate immune responses to viruses may influence the susceptibility to infection. This study used whole-genome analyses of lung tissue to identify polymorphisms acting as expression quantitative trait loci (eQTLs) for 60...

pubmed.ncbi.nlm.nih.gov

’TRIM5’

Similar to human TRIM5, a bat can also fail in its defense by TRIM5:

Sep 2020 Australia, Colorado, Singapore: Yinpterochiropteran Bat / TRIM5

A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat - PubMed

Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2. The innate immune systems of these...

pubmed.ncbi.nlm.nih.gov

’....Viral nuclear import was significantly decreased, and this deficit was substantially rescued by cyclosporine treatment....However, saturation with HIV-1 virus-like particles did not relieve the restriction at all. P. Alecto TRIM5 was inactive against HIV-1, although it blocked the gammaretrovirus N-tropic murine leukemia virus.’

 

[badger2]

Now analyzing the HIV-1 inserts mentioned in post #404, which study states: ‘....it is unlikely for a virus to have acquired such unique insertions naturally in a short duration of time.’ We are still searching for the amount of time the authors are talking about, and indeed they are identical to HIV-1: ‘....the insert 1 (6 amino acid residues) and insert 2 (6 amino acid residues) in the spike glycoproptein of 2019-nCoV are 100% identical to residues mapped to HIV-1 gp120.’

 

[badger2]

It was a dead give-away for the CDC to change their webpage for the P.1 variant at position 417, because it shows that the virus was using either aspartic acid or threonine. Originally published as K417N/T, it is highly unlikely to be a typo, and because of the threonine, is a link to (other members [italics]) of the coronavirus family. They removed the asparagine, and the new change is ‘K417T.’

 

[badger2]

From post #404, Sorenson and Andres Susrud both work at Immunor (Norway), and Dalgleish is Professor of Oncology at St. George’s University, London. All three own shares or have stock options in the company.

 

[badger2]

CDC, having removed the fentanyl evidence (N) at position 417 of the P.1 Brazil-Japan variant from their webpage, now links to Public Health England at position 417:

18 hours ago, Portugal Removed From UK Green List

Covid travel rules: Portugal removed from UK green list as seven others join red list

The country will join the amber list from Tuesday, as seven others are moved to the red list.

www.bbc.co.uk

’....On the so-called “Nepal mutation,” Public Health England told BBC it was “aware of reports linking Nepal to Delta (VOC-21Apr-02) with the additional mutation K417N....PHE said “We are investigating K417N to better understand its significance.” ‘

Thus, the N (asparagine) that the CDC removed from their page only differs from D (aspartic acid) of the D614G mutation, by a single hydrogen atom. The significance is that asparagine is the residue that shows how COVID-19 mimics the increased potency of fentanyl at the mu-opioid receptor. Janssen Pharmaceutica, a division of Johnson & Johnson, is the origin of fentanyl.

 

[badger2]

Two COVID-19 Alzheimer-like mutations we have mentioned, N501Y and A483V, link to what is being called “long covid.”

11 Jan 2021 COVID-19 Severity and Gut Bacteria

https://newatlas.com/health-wellbeing/gut-bacteria-microbiome-covid-19-severity-coronavirus-inflammation/

‘....could play a role in everything from depression and obesity to Alzheimer’s.’

 

[badger2]

The full title of the article is COVID-19 Severity Linked to Gut Bacteria in First-of-Its-Kind Study. We will take a closer look at the bacteria mentioned: Ruminococcus gnavus, R. torques and Bacterioides dorie, because they may point to an intermediate host-reservoir in nature (‘unusually higher volumes’).

 

[badger2]

Bacteroides, above, links COVID-19 to Hashimoto’s thyroiditis

Jul 2020 Singapore

COVID-19 complicated by Hashimoto's thyroiditis - PubMed

COVID-19 complicated by Hashimoto's thyroiditis

pubmed.ncbi.nlm.nih.gov

Ruminococcus torques biota increase found in Hashimoto’s
2018 China

Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients - PubMed

Characterization of the gut microbiota in HT patients confirmed that HT patients have altered gut microbiota and that gut microbiota are correlated with clinical parameters, suggesting that microbiome composition data could be used for disease diagnosis. Further investigation is required to...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

A refutation of Sorenson’s claim (post #404) by Sir Richard Dearlove:
18 Jun 2020

A Norwegian-British research paper doesnât claim the virus causing Covid-19 was man-made - Full Fact

There is still no evidence to suggest that the new coronavirus was man-made.

fullfact.org

Dearlove was Chief of British MI6 from 1999 to 2004.

 

[badger2]

While searching for the actual env retroviral excerpt found in The Nidoviruses, a May 2021 report links env to HIV-1 and COVID-19, recalling that Sorenson, et al, inserts (above) are for gp120 env of HIV-1:

May 2021 Env / HIV-1 / SARS-CoV-2, NIH, Duke Human Vaccine Institute, Perelman School of Medicine, Boston Children’s Hospital, Beth Israel Deaconess, Harvard Medical School, Swarthmore College, Memorial Sloan-Kettering, Institute of Macromolecular Chemistry, Prague

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies - PubMed

Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan...

pubmed.ncbi.nlm.nih.gov

’....Here we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without Vh-swapped domains from SHIV (simian human immunodeficiency virus)-infected macaques. FDG also recognized cell-surface glycans on diverse pathogens, including yeast and SARS-CoV-2 spike.’

 

[badger2]

Moving along the trajectory linked to Africa, there are now two major world viruses whose natural reservoirs have apparently not been found.
In a special issue of Ecology of Virus Emergence From Wildlife, there is an Eco Health Alliance connection for African coronaviruses:

18 May 2021 Overview of Bat and Wildlife Coronavirus Surveillance in Africa: A Framework for Global Investigations

Overview of Bat and Wildlife Coronavirus Surveillance in Africa: A Framework for Global Investigations

The ongoing coronavirus disease 2019 (COVID-19) pandemic has had devastating health and socio-economic impacts. Human activities, especially at the wildlife interphase, are at the core of forces driving the emergence of new viral agents. Global surveillance activities have identified bats as the...

www.mdpi.com

’....Eco Health Alliance, New York....’

 

[LordBrownTrout]

Yes, LBT, we’d like to know about the inserts, because retroviral elements can naturally integrate into the coronavirus genome, without human manipulation. Fauci likely was involved in early HIV vaccine research, and all that Rand Paul has to do in public is to mention the D614G mutation, that precisely links to ebola vaccine.

Furthermore, Fort Detrick’s study on increased potency of the venom of one of the suspected hosts of SARS-CoV-2, Bungarus, is problematic, because a subspecies of this genus, B. wanghaotingi, has apparently not yet been sequenced. This subspecies may occur near to RaTG13. Thus, Bungarus as intermediate host of SARS-CoV-2 cannot yet be ruled out. One important thing to do is to document the precise geographical location of C-19’s closest relative, RaTG13, from Yunnan Province.

We mentioned Daszak’s work, which goes back to 2011, in conjunction with the nasty Kunming animal market, not the Wuhan seafood market, on 13 Feb 2020. Daszak is co-author of the second entry of post #404:

Post #404

Snake Meat......source of chinese virus

The Chinese eat badgers. Snakes Are The Likely Source of China's Deadly Coronavirus. Here's Why In the case of this 2019 coronavirus outbreak, reports state that most of the first group of patients hospitalized were workers or customers at a local seafood wholesale market which also sold...

www.usmessageboard.com

That D614 keeps appearing again and again and again which should send up some blaring red flags.

 

[badger2]

Yes, LBT, the D614G mutation is primitive, because it goes to glycine rather than what Fauci said, aspartic acid. Rand Paul’s D614G question to Fauci connects the dots to Africa for ebola, because the Kansas cow is the basis for ebola vaccine, not a cow from Indiana. The D614G mutation precisely causes increased replication of the VSV virus from the Kansas cow.

A major clue to COVID-19’s origins was published by India on 20 Oct 2020, at the precise location where COVID-19’s closest relative, RaTG13, was found:

20 Oct 2020 India: Lethal Pneumonia in Miners, Tongguan, Mojiang County, Yunnan

Lethal Pneumonia Cases in Mojiang Miners (2012) and the Mineshaft Could Provide Important Clues to the Origin of SARS-CoV-2 - PubMed

With the COVID-19 pandemic reaching its worst heights, people are interested in the origin of SARS-CoV-2. This study started with two important questions: first, were there any similar atypical pneumonia outbreaks, even on a smaller level, reported between SARS in 2004 and COVID-19 in 2019/20 in...

pubmed.ncbi.nlm.nih.gov

’....A Master’s thesis (in the Chinese language) was found on the ckni.net website which described in detail the severe illness of the miners.’