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COVID-19’s Biological Politics

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badger2

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G910V Mutation in Ehlers-Danlos Syndrome / Cyanogen Bromide

The L452R mutation in the Henri-Mondor variant also occurs in USA (California). We are tempted to suggest that this mutation occured in a Chinese-American Californian, because of the connection to green tea polyphenols. Note that you don’t have to forget the Alzheimer’s-like mutations previously posted either, because polyphenols are beneficial in Alzheimer’s prophylaxis, and thus may be a link to both the alanine-to-valine and leucine-to-arginine (L to R) mutations in COVID-19:

Italy: L858R Non-Small Cell Lung Cancer

Green Tea Polyphenols (Epigallocatechin-3-Gallate) / COVID-19
 
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Bonjour, Dalia,

It is interesting that a Frenchman, Felix Guattari, wrote a passage that resonates with Zika in New Caledonia, a French outlier:

’Except that this crazy race reaches its limit with California on one side and Japan on the other. The second pathway for Capital has looped back on itself, the world has closed up and the system is saturated. (The last power to notice will doubtless be France, perched on its atoll in Muroroa!).’
(Guattari, Cartographies schizoanalytiques, 1989)

Amicalement, badger2
 
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How many in France have Ehlers-Danlos and also have had either the COVID-19 vaccine or the infection itself? That population could yield clues to the vaccine’s efficiency and/or help to elucidate more about variants. The Paris conference, scheduled for 24-25 Ap 2021, has been cancelled:

 
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Bonjour, Dalia,

There is more to learn about the Henri-Mondor variant mutation, G910V(glycine-to-valine) as it relates to Ehlers-Danlos syndrome. By chance we glanced at previous posts and saw Rab3 gene, excerpting from Epstein’s Book, Inborn Errors of Development. We have already mentioned Zika in French Polynesia and New Caledonia, though had forgotten the Rab5 connection to Zika. A Pubmed search ‘ehlers-danlos rab’ yielded two references, both are proteins that interact with the rab gene:

Ehlers-Danlos / Rab / RIN2

Ehlers-Danlos / Rab / RIN2
 
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We now see that rab genes play an important role in C-19 infection, so Ehlers-Danlos in the French population would be an interesting group, especially with the Henri-Mondor variant:

Oct 2020 Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
’....Figure 3: Enriched Gene Cluster....Rab7a....’

Functional Interrogation of a SARS-CoV-2 Host Protein Interactome Identifies Unique and Shared Coronavirus Host Factors (Rockefeller University, Heidelberg University, Vienna, etc.)
’....Fig.1a: Rab 10, 14 & 2a....’
 
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It is interesting that Henri Mondor variant does not contain the E484K (glutamic acid 484 lysine) mutation, whereas the B.1.1.7 variant does. Investigating Ehlers-Danlos and Marfan syndromes will implicate the lysyl moiety.
 
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Any COVID-19 vaccine breakthroughs must consider the E484K, and this Italian report from Dec 2020 shows why:

Dec 2020 Italy: SARS-CoV-2 Escape From Convalescent Serum
’ deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies....after 45 days, deletion of F140 in spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, and E484K substitution in the RBD occurred....the single mutation in the RBD (E484K) swaps the charge of the sidechain, which would significantly alter the electrostatic complementarity of antibody binding to this region.
....
The F140 alters the packing of the N1, N3 and N5 loops, where the loss of the bulky aromatic sidechain would overall reduce the stability of this region. Subsequently, the extensive insertion within the N5 loop appears to remodel this critical antigenic region, predicting substantial steric occlusion with antibodies targeting this epitope, sucxh as antibody 4A8. Furthermore, introduction of a new N-glycan at position N248 (mutant numbering system) would effectively eliminate neutralization by such antibodies.
....
In conclusion, we have shown that the authentic SARS-CoV-2 virus, if pressured, has the ability to escape a potent polyclonal serum targeting multiple neutralizing epitopes....In the RBD, the possibility to escape is limited and the mutation E484K that we found is one of the most frequent mutations to escape monoclonal antibodies and among the most common RBD mutations described in experimental settings as well as in natural isolates posted in the GSAID database.
....
Surprisingly, only three mutations, which led to complete rearrangement of NTD N3 and N5 loops and substitution to a key residue on the RBD, were sufficient to eliminate the neutralizing ability of a potent polyclonal serum. Therefore, it will be important to closely monitor which epitopes on the S-protein are targeted by the vaccines against SARS-CoV-2 that are going to be deployed in hundreds of millions of people around the world.’
 
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Window D of Figure 3 in the above report shows the proximity of E484K to ACE2.
 
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Obviously, the rabid media has no intention of clarifying the discourse about variants, because their agenda is sensory-motor, surrogate for insight and knowledge. The P.1 variant is identical to the South African B.1.351 variant, the only exception being an occasional threonine at position 417 instead of an asparagine. Because of this, the following report is indirectly stating that threonine is the amino acid that is making the virus particularly virulent:

Not surprisingly, the URL is booby-trapped with cookies:
’....France is suspending all flights to and from Brazil to curb spread of a new COVID-19 variant, P.1.....is particularly virulent and partly to blame for coronavirus death toll in March....”The situation is worsening,” Prime Minister Castex told Parliament.’

P.1 Variant, Brazil/Japan

K417N/T
E484K
N501Y
D614G
 

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The COVID Experiment: Are You Covered?

“Why did Moderna fail to disclose $20 million from DARPA for the development of vaccine patent technology being used today?”


Why do people who have avoided the annual flu vaccine suddenly trip over themselves to inject an experimental shot? Why do they do it with so many questions left unanswered? What ingredients are in the shot? What does it offer? Will you be invincible? What are the known and unknown consequences of an experimental jab? What if something goes wrong?

I. Identify the Known Knowns:

For many months, mainstream media has announced itself as the gatekeeper of your health information for all things COVID. It first reported that the Pfizer and Moderna COVID injections do not prevent infection of the Coronavirus. Later, they were unsure if their products prevented transmission. Then an April 2021 study reported that COVID variants can still infect vaccinated people. The story changed again in the same month, “A new study shows the Pfizer vaccine does prevent transmission.”

This is the realm of the Known Knowns, with the caveat that what we know can shift at any given moment.

Transmission of what, exactly? Who knows.

For many months, mainstream media has promoted the transmission of a “deadly virus” but failed to mention that the Coronavirus, also known as Covid-19, has never been isolated. In December 2020 investigations, “no quantified virus isolates of the 2019-nCoV were available.” See December 2020 CDC document, page 43. The document also mentions that testing for “the virus” is woefully inadequate. Page 41: “This test cannot rule out diseases caused by other bacterial or viral pathogens.”


If there is no known virus, and no accurate test, how can there be an effective viral vaccine? Hence, an experimental vaccine!

Could the real threat instead be a bacterium, as Dr. Fauci suggested in a 2008 Journal of Infectious Diseases article, about the last major pandemic?

Could the real threat be the advertised cure?

In January 2021, CNN reported, “Don’t be alarmed if people start dying after taking the vaccine.” Is that why deaths are now soaring in Brazil?

Could the real threat be the Big Three vaccine makers, Pfizer, Johnson & Johnson, Astra Zeneca, whose rap sheets are so long they make the mob look innocent? Moderna claims it’s vaccine is really “a computer operating system.” Is that the reason for more side effects than the others?

Learn more:


Sources:










 
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Thanks for the contribution #331. We sorely need more documented history on C-19 and vaccine makers. So why didn’t they use the best model for vaccines, the natural reservoir?
 
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“In other words, you may want to hold off for a bit.”
(Anthony Fauci)

Our investigative trajectory concerning Astrazeneca’s vaccine and blood clotting began with this report:

’....more women than men....’

In that case, we’ll recall the female stats for Alzheimer’s vs. male stats.

’German scientists at Griefswald University: vaccine-induced immune thrombotic thrombocytopenia....a separate group of Norwegian scientists have made similar conclusions....a recommendation for an alternative vaccine for people under 30....So far, risk factors like age or gender have not been singled out....CVST 62 cases, SVT 24 cases....’

The South African variant B.1.1.7 contains an Alzheimer’s-like mutation, N501Y, thought the Henri Mondor variant contains two of them: N501Y and A653V. The A653V (alanine-to-valine) links to early onset Alzheimer’s in the Japanese genome, thus linking age of the blood clotting post-vac females (18-48 yrs) to Japanese early-onset Alzheimer’s (26-30 yrs). Britain’s Medicines and Healthcare Products Regulatory Agency made a recommendation for an alternative vaccine for people under 30 years of age.
 
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Reviewing Japanese early-onset Alzheimer’s, post #16:

‘....alanine to valine: 40.3 years; valine to alanine: 26-26 years.’
 
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Thus according to the Japanese genomic presentations, we will speculate that the Henri Mondor variant, found in 31 countries, links its alanine-to-valine mutation @ 653 to the time window around 40 years of age. We now link C-19’s vaccine side-effect, CVST, to SLE (systemic lupus erythematosis) and “Trump’s” hydroxychloroquine to SLE:

Hep B is well known for causing vasculitis:

CVST / SLE
’....vaginal bleeding....hepatitis B virus....vascilitis due to endothelial cell injury mediated by immune-complex deposition is proposed to be the pathogenesis of CVST in SLE.’

SLE / Hydroxychloroquine (British Medical Journal)
’....Hence, hydroxychloroquine use might be an explanation for no report on SLE patients with COVID-19.’
 
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This was reported on the 15th, and normally, viral genomes will contain 30-40K base-pairs:

15 Ap 2021 Laboratories in U.S. Can’t Find COVID-19 in 1500 Positive Tests
 
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We compare the CVST symptom caused by Astrazeneca vaccine with Alzheimer’s, and find a coagulation link, recalling that the Henri Mondor variant contains two Alzheimer’s-like mutations:

CVST / CVSS / Fibrinogen
’....CVST increased 94.1% d-dimer and fibrinogen....in CVSS, both are only increased 17%.’

Alzheimer’s Fibrinogen
’....to review the evidence that the Alzherimer’s peptide, beta-amyloid, interacts with the blood coagulation system and influences the pathophysiology of the disease.’
 
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The Alzheimer’s article in post #338 mentions coagulation factor XII. The Hungarians were among the first to report on a coagulation link to COVID-19:

Dec 2020 Hungary / COVID-19 and Age-Dependent Bradykinin Storm / Coagulation Factor XII

We dealt with bradykinin and maximakinin on the Snake Meat thread.

Thusfar, both COVID-19 Alzheimer’s-like mutations (N501Y and A653V) relate to either presenilin or age-dependence.
 
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The Hungarian COVID-19 report above mentions hantavirus and coagulation factor XII.

2013 U.S. Army Medical Research Institute, Ft. Detrick, Maryland, USA
Coagulation Factor XII / Hantavirus
 

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