CDCs “confusing” messaging on vaccines.

[badger2]

Now that SARS-CoV-2 antibodies have been discovered in deer in Illinois, Mi., NY and Pennsylvania, and it has been shown that they are susceptible to infection, tracking NIH/Fau Chi connections (already shown) to the CTLA4Hinge vaccine for the civet-cat reservoir of SARS-CoV, brings the story to North America, where potential exists for deer to transmit C-19 to humans.

 

[badger2]

How does a mutation in COVID's spike protein affect the mu-opioid receptor?

What does it mean to have "all of the requirements to increase the potency of fentanyl"?

These particular amino acids the virus is choosing to use are the same ones that increase potency of fentanyl and link to the opioid receptor. Recall that Janssen originally synthesized fentanyl, and Janssen Pharmaceutica is a division of J&J vaccine.

 

[badger2]

Which prompts the question of nociception/pain as it relates to just (one-shot [italics]) vaccines. What did J&J know about nociception linked to the commie virus? Wiki’s Nociception page showsin TRPV 1-6. We believe we once tracked this to Columbia and eraly-onset Alzheimer’s, so analysis of Columbian variants is in order. Also, TRPV links to a South American freshwater stingray and compounds that were once used in Alzheimer’s experimental therapy, which citations require a review.

Nociception

Nociception - Wikipedia

en.wikipedia.org

 

[TheProgressivePatriot]

Guess what genius? Before the vaccine was developed 100% of the people who contracted covid and hospitalized were UNvaccinated, and 99% of those people survived.

I think I'll take my chances.

Is that why hospitals and funeral homes had to establish make-shift morgues in refrigerated trucks in their parking lots? You might also want to consider what :survival" means. Many Covid victums who do not die not not really get well either.

 

[Lesh]

For a few months

So I guess StupidSue is black?

Because according to Trump Humpers it's only blacks who are hesitant to get vaxxed..

 

[Lesh]

Delta does not have the ‘fentanyl’ mutation (K417N/T), which may influence antibody statistics and permanence depending on each particular patient. More on T cells is here:

Convergent Epitope-Specific T Cell Responses

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence and breakthrough infections have changed vaccine policy to include booster immunizations. However, the effect of diverse and repeated antigen exposures on SARS-CoV-2 memory T cells is poorly understood. Here...

doi.org

’....BnT162b2 vaccination elicits potent spike-specific T-cell responses in naive individuals and also triggers the recall T cell response in previously infected individuals, further boosting spike-specific responses but altering their differentiation state. Overall, our study demonstrates the potential of mRNA vaccines to induce, maintain, and shape T cell memory through vaccination and revaccination.’

Jesus. Save the word salad.

 

[sakinago]

Is that why hospitals and funeral homes had to establish make-shift morgues in refrigerated trucks in their parking lots? You might also want to consider what :survival" means. Many Covid victums who do not die not not really get well either.

The panic porn is strong with this one. I’m actually waiting for the day Fauci starts talking about metachlorines as a reason to get the vaccine. It’d be right on par with the pseudoscience he’s been pushing.

 

[colfax_m]

These particular amino acids the virus is choosing to use are the same ones that increase potency of fentanyl and link to the opioid receptor. Recall that Janssen originally synthesized fentanyl, and Janssen Pharmaceutica is a division of J&J vaccine.

Asparagine is one of 23 amino acids. It’s hard to find a protein it isn’t present in.

 

[badger2]

Asparagine is one of 23 amino acids. It’s hard to find a protein it isn’t present in.

Recall that in this thread we have already mentioned that the classification of the Beta and Gamma variants relies on K417N and K417T.

Janssen Pharmaceutica in Belgium, this report from Leuven:

Asn230 / Mu-Opioid Receptor Mutation / N/T
https”//pubmed.ncbi.nlm.nih.gov/11588103
’....potency of morphine and fentanyl can be explained by mutating this residue towards more hydrophobic amino acids.’

 

[badger2]

The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists - PubMed

1. To investigate the effect of the hydrophilic Asn amino acid at position 230 of the human mu-opioid receptor (hMOR230) on the potency of various agonists, we mutated this residue to Thr and Leu (hMORN230T and hMORN230L respectively). 2. Taking advantage of the functional coupling of the opioid...

pubmed.ncbi.nlm.nih.gov

 

[colfax_m]

Recall that in this thread we have already mentioned that the classification of the Beta and Gamma variants relies on K417N and K417T.

Janssen Pharmaceutica in Belgium, this report from Leuven:

Asn230 / Mu-Opioid Receptor Mutation / N/T
https”//pubmed.ncbi.nlm.nih.gov/11588103
’....potency of morphine and fentanyl can be explained by mutating this residue towards more hydrophobic amino acids.’

So?

 

[sakinago]

Over 95% of hospitalized covid patients are UNvaccinated genius

Wanna figure those odds?

If I get covid now my chances of getting really sick are a LOT lower than yours.

And guess what? You WILL get the virus because the Delta variant is SO fucking contagious

I MIGHT get it...but again...if I do I have a much smaller chance of getting very sick.

This stat is one of the biggest lies told by fauci and his bishops in the mainstream media. That data is coming from dec/Jan when the vaccine was barely in circulation. So yeah 95% of people in the hospital didn’t have the vaccine because like only 10 people actually got both doses of the vaccine.

See, when your on the side that’s skewing data this egregiously, you are not on the right side. How are you okay with fauci and his bishops lying to you like that???? I’d be fucking pissed

 

[badger2]

So?

Dec 2020 SARS-CoV-2 / Hydrophobic

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies - PubMed

The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein^1-5 show promise therapeutically...

pubmed.ncbi.nlm.nih.gov

’....Fig. 1: C144 CDRH3 residues F100D and W100E are buried in a hydrophobic pocket comprising the RBS alpha1 helix, residue F374 (RBD) and the N343(RBD)-glycan....In addition, the binding orientation observed for C144 differs from the binding described for COVA2-39, whose RBD epitope is predicted to be accessible only on “up” RBDs, due to steric hindrance imposed on the LC by the N343(RBD)-glycan on the adjacent RBD. Despite orientation differences, the RBD epitopes of C144m C102 and COVA2-39 overlap with the ACE2 binding site, suggesting a neutralization mechanism involving direct competition with ACE2.’

That’s asparagine 343(RBD).

 

[badger2]

This stat is one of the biggest lies told by fauci and his bishops in the mainstream media. That data is coming from dec/Jan when the vaccine was barely in circulation. So yeah 95% of people in the hospital didn’t have the vaccine because like only 10 people actually got both doses of the vaccine.

See, when your on the side that’s skewing data this egregiously, you are not on the right side. How are you okay with fauci and his bishops lying to you like that???? I’d be fucking pissed

Fau Chi tried to do the same thing in his video with the ‘eyebrow-raising’ mutation D614G (which he got backwards due to a Freudian slip of some kind, or lack of knowledge). Chinese call it ‘moth eyebrows.’

 

[colfax_m]

Dec 2020 SARS-CoV-2 / Hydrophobic

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies - PubMed

The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein^1-5 show promise therapeutically...

pubmed.ncbi.nlm.nih.gov

’....Fig. 1: C144 CDRH3 residues F100D and W100E are buried in a hydrophobic pocket comprising the RBS alpha1 helix, residue F374 (RBD) and the N343(RBD)-glycan....In addition, the binding orientation observed for C144 differs from the binding described for COVA2-39, whose RBD epitope is predicted to be accessible only on “up” RBDs, due to steric hindrance imposed on the LC by the N343(RBD)-glycan on the adjacent RBD. Despite orientation differences, the RBD epitopes of C144m C102 and COVA2-39 overlap with the ACE2 binding site, suggesting a neutralization mechanism involving direct competition with ACE2.’

That’s asparagine 343(RBD).

If there’s a point to this, you sure don’t really want to talk about it.

There is not in any way a connection between the spike protein and the mu receptor. Having the same amino acid isn’t a link.

 

[badger2]

The following report links COVA2-39, above, to the Consortium for HIV/AIDS Neutralizing Antibody Center Vaccine Development:

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain - PubMed

IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural constraints in binding the RBD (mode A). However, a small...

pubmed.ncbi.nlm.nih.gov

’Affiliations: Urbana, Illinois; Amsterdam, The Netherlands, La Jolla, California, Neutralizing Antibody Center Vaccine Development....COVA2-04 has a relatively short CDR H3 of 10 amino acids, whereas COVA2-39 CDR H3 is 15 amino acids....has three somatic mutations in the heavy chain (HL) and one in the light chain (LC).’

 

[badger2]

If there’s a point to this, you sure don’t really want to talk about it.

There is not in any way a connection between the spike protein and the mu receptor. Having the same amino acid isn’t a link.

You are incorrect because of your lack of hydrophobic knowledge: rabies.

 

[colfax_m]

You are incorrect because of your lack of hydrophobic knowledge: rabies.

I’m well aware. I actually did my undergraduate thesis on site directed mutagenesis in an enzymatic lab. I was swapping out lysine for leucine to see it’s effect on pH at the active site.

But the idea that a single amino acid connects two totally different proteins demonstrates your have no idea what you’re talking about and you’re refusal to make any point whatsoever is further proof.

 

[badger2]

I’m well aware. I actually did my undergraduate thesis on site directed mutagenesis in an enzymatic lab. I was swapping out lysine for leucine to see it’s effect on pH at the active site.

But the idea that a single amino acid connects two totally different proteins demonstrates your have no idea what you’re talking about and you’re refusal to make any point whatsoever is further proof.

You leave out the lysine at position 417 while lauding yourself about lysine?

 

[colfax_m]

You leave out the lysine at position 417 while lauding yourself about lysine?

Leave out? This entire discussion has been completely nonsensical.