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United States Patent 6,630,507
Hampson , et al. October 7, 2003
**Please see images for: ( Certificate of Correction ) **
Cannabinoids as antioxidants and neuroprotectants
Abstract
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##
Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Family ID: 26767641
Appl. No.: 09/674,028
Filed: February 2, 2001
PCT Filed: April 21, 1999
PCT No.: PCT/US99/08769
PCT Pub. No.: WO99/53917
PCT Pub. Date: October 28, 1999
Current U.S. Class: 514/454
Current CPC Class: A61K 31/35 (20130101)
Current International Class: A61K 31/35 (20060101); A61K 031/35 ()
Field of Search: ;514/454
References Cited [Referenced By] U.S. Patent Documents
2304669 December 1942 Adams
4876276 October 1989 Mechoulam et al.
5227537 July 1993 Stoss et al.
5284867 February 1994 Kloog et al.
5434295 July 1995 Mechoulam et al.
5462946 October 1995 Mitchell et al.
5512270 April 1996 Ghio et al.
5521215 May 1996 Mechoulam et al.
5538993 July 1996 Mechoulam et al.
5635530 June 1997 Mechoulam et al.
5696109 December 1997 Malfroy-Camine et al.
6410588 June 2002 Feldmann et al.
Foreign Patent Documents
[...]
Other References
[...]
United States Patent: 6630507
Hampson , et al. October 7, 2003
**Please see images for: ( Certificate of Correction ) **
Cannabinoids as antioxidants and neuroprotectants
Abstract
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH.sub.3, and COCH.sub.3. ##STR1##
Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Family ID: 26767641
Appl. No.: 09/674,028
Filed: February 2, 2001
PCT Filed: April 21, 1999
PCT No.: PCT/US99/08769
PCT Pub. No.: WO99/53917
PCT Pub. Date: October 28, 1999
Current U.S. Class: 514/454
Current CPC Class: A61K 31/35 (20130101)
Current International Class: A61K 31/35 (20060101); A61K 031/35 ()
Field of Search: ;514/454
References Cited [Referenced By] U.S. Patent Documents
2304669 December 1942 Adams
4876276 October 1989 Mechoulam et al.
5227537 July 1993 Stoss et al.
5284867 February 1994 Kloog et al.
5434295 July 1995 Mechoulam et al.
5462946 October 1995 Mitchell et al.
5512270 April 1996 Ghio et al.
5521215 May 1996 Mechoulam et al.
5538993 July 1996 Mechoulam et al.
5635530 June 1997 Mechoulam et al.
5696109 December 1997 Malfroy-Camine et al.
6410588 June 2002 Feldmann et al.
Foreign Patent Documents
[...]
Other References
[...]
United States Patent: 6630507