No, not really. As it would be a sitting duck.
The LCS was always a stupid idea, and most of us that looked at the development of it laughed when it was first proposed. The "Little Crappy Ship" was always a boat in search of a mission that simply did not exist.
But for defense of an amphibious group and providing shore bombardment in the event that amphibious group is needed is a real mission, and one that our amphibious groups do not have any kind of support for. Want to seam one of these by itself and think it can not be touched? Well, the Germans and Japanese both thought that as they sent their "Supper Battleships" by themselves into harms way. And we all know how those turned out.
They turned into really nice artificial reefs. The same thing would happen to this if that was tried.
How is it a sitting duck? Other than antenna's that would have to be replaced, and potential shock damage to electronics, there is not much out there except for a torpedo that can harm one of those vessels. This now, an Exocet, hitting perfectly, at optimal distance from launch, will penetrate 3.2" inches of armor. The best ASM the Russians or chinese have will penetrate 4 inches. That will barely make it through the deck armor, but the splinter armor below contains it. And, once again, that is with an optimal hit.