IMNSHO and of those I know about, you can remove the following from the list:
15. Watchmen, by Alan Moore (It's a graphic novel aka comic, not a book. Belongs on a different list)
23. The Dark Tower Series, by Stephen King (and I LIKE King, but this isn't groundbreaking or Top anything)
29. The Sandman Series, by Neil Gaiman (comicbook series... see Watchman)
45. The Left Hand Of Darkness, by Ursula K. LeGuin (God she sucks with nothing original to say)
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Too many 'sexy' picks like 5 works by Neil Gaiman? I mean he's good, but that good? Besides, "Good Omens" was pretty damn innovative for fantasy-comedy.
Ones I was happy to see:
14. Neuromancer, by William Gibson (Dude, he Created Cyberpunk)
20. Frankenstein, by Mary Shelley (Invented Science Fiction AND horror in one book)
22. The Handmaid's Tale, by Margaret Atwood (politically, whatever. But an awesome read)
25. The Stand, by Stephen King (A top 5 book for me)
32. Watership Down, by Richard Adams (Extremely happy another top five book for me)
38. Flowers For Algernon, by Daniel Keys
79. Something Wicked This Way Comes, by Ray Bradbury (The movie is good too)
100. The Space Trilogy, by C.S. Lewis
Omissions I wish I could have seen:
"On Basilisk Station." David Weber did a phenomenal job in telling hard sci fi space combat in a new way.
"Bloom" by Wil McCarthy. Outstanding view of a nano-pocalypse. His Queendom series is phenomenal too. How many duplicates of you do you really need or should have before trouble sets in?
"Jurassic Park" Michael Crichton. Come on... think about it. Theme Parks plus Dinosaurs equals PROFIIIIIIT! Oh wait I mean DISASTERRRRRR!!!!
"Hammers Slammers" David Drake. Sci fi tanks and soldiers would never be the same. I suppose you could also include Keith Laumer's "Bolo" series in this, but I've never read it. Another good one by him is "Redliners" where a burnt out military unit must protect colonists from an ecology turned weapon.
"Software" Rudy Rucker. Cybersurrealism???? Oh yeah... and mathematically wild. What is reality anyway and why is it mandatory?
and a few from Alan Dean Foster
"Nor Crystal Tears". First contact from the point of view of the alien.
"Sentenced to Prism" A look at a silicon and solar based life form world
The "War against the Chtorr" series by David Gerrold. What if it wasn't one species invading Earth but an entire ecosystem? This should be a top 25 instead of Urpsila K. LeCrap.
Oh and where the FUCK is the "Chronicles of Narnia"??? Top 20 easy. Remove a fanboy Neil Gaiman book, and bump all the others down from American Gods and slot that bad boy in at #10 and be done with it. Far more important and popular. Not to mention "The Screwtape Letters" and "The Great Divorce". I'd consider both of those FAR more important and innovative fantasy than even C.S. Lewis's Space trilogy. what'd they do? Dock points for Christianity???
And where is Harry Potter (regardless of the fact I'll never read it.)?