That's where the cut blocks come in. A low trajectory reduces risk. The QB can throw to a spot instead of a player.
I'm not sure what you mean by "cut block" but chop blocks are illegal. Trajectory has nothing to do with it, this is about location, there are 5-8 players around the ball, it can bounce off them all kinds of ways and get intercepted. You mitigate this by throwing to the outside, away from the hoard in the middle protecting against the run.
A cut block is in the legs of a defender. OL need to get into the legs of DL to force them to crouch and open up a throwing lane over them. Back in the day a team would employ a jump pass in the same scenario.
As for outflanking the defensive interior, the NFL centered the hash marks back in the early 1970's in order to remove defensive leverage coverages and make passing the ball across a TV screen easier. Unfortunately, that very same lack of leverage hurts an
offense when close to the goal line. If the hash marks were still in thirds or at least as far apart as they are in college an offense could leverage the defense with the ball on the hash and create an entire 2/3 of the width of the field to stretch a defense in order to only gain a couple or three yards vertically. Ohio St used that strategy when they went for 2 against Alabama after their last TD in that game this year. They had the officials put the ball on the left hash and they ran a three-tiered play to the right. NFL can't do that. Not enough width. I think there was that same situation that hurt the 49ers in the Super Bowl a couple of years back.