This is what happened to the Roanoke colony. Eleanor and six others were still alive in 1591, the year after her father came back and found them gone. The stone was found upriver on the mainland, not on or near Croatan. Reports of these survivors continuing to live among the natives persisted at least until John Smith began hunting for them in 1607 or so.
That is why it is a mystery. Her husband and child's gravestone is out there somewhere, too, if anyone can figure out where "hither" is.
[Side 1]:
Ananias Dare &
Virginia Went Hence
Unto Heaven 1591
Anye Englishman Shew
John White Govr Via
Side 2]:
Father Soone After You
Goe for England Wee Cam
Hither / Onlie Misarie & Warre
Tow Yeere / Above Halfe Deade ere Tow
Yeere More From Sickenes Beine Foure & Twentie /
Salvage with Message of Shipp Unto Us / Smal
Space of Time they Affrite of Revenge Rann
Al Awaye / Wee Bleeve it Nott You / Soone After
Ye Salvages Faine Spirits Angrie / Suddaine
Murther Al Save Seaven / Mine Childe /
Ananais to Slaine wth Much Misarie /
Burie Al Neere Foure Myles Easte This River
Uppon Small Hil / Names Writ Al Ther
On Rocke / Putt This Ther Alsoe / Salvage
Shew This Unto You & Hither Wee
Promise You to Give Greate
Plentie Presents
EWD