Found an interesting article published by Medscape today. It was published on March 31. Quoting a portion of it below. Constructive feedback welcome.
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(Reuters) - Researchers may have found an explanation for the rare but serious blood clots reported among some people who received AstraZeneca's COVID-19 vaccine.
They believe the phenomenon is similar to heparin-induced thrombocytopenia (HIT), in which heparin triggers the immune system to produce antibodies that activate platelets. Drugs other than heparin can cause clotting disorders that strongly resemble HIT, and the researchers suspect that in rare cases, the AstraZeneca vaccine may be another such trigger.
Four previously healthy individuals who got the AstraZeneca shot and developed life-threatening clots had the same kind of antibodies that activate platelets and initiate clotting in HIT, the researchers reported in a paper posted on Research Square ahead of peer review.
Twenty individuals who received the vaccine but did not develop clots did not have these antibodies.
An editorial comment posted with the study noted that drug-induced thrombocytopenia is treatable if identified promptly.
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Source:
Researchers may have found an explanation for the rare but serious blood clots reported among some people who received AstraZeneca's COVID-19 vaccine.
www.medscape.com
The study they are referring to is here:
A Prothrombotic Thrombocytopenic Disorder Resembling Heparin-Induced Thrombocytopenia Following Coronavirus-19 Vaccination Research Square, online March 29, 2021.
Oh stop it---the vaccines and virus act like an allergic reaction? gee, I wonder how many people have been posting that this is what both the virus and vaccine do---hence why the symptoms are worse with each subsequent exposure. Boosters they think will be needed every 6 months btw---
in order to stabilize the vaccine, they added PEG which we are exposed to regularly. it prevents the body from breaking down the vaccine's properties. that glycol is partly responsible for many of the anaphylactic reactions.
btw, the PEG is what is going to keep the components in your cells for a very long time. your body will never be the same and literally take over your immune system.
I definitely agree that the issue of PEG in Pfizer and Moderna's vaccines is cause for concern. RFK Jr's Children's Health Defense site came up with 5 questions they'd like Fauci and the FDA to answer. The very first question deals with PEG and how it can cause ADAs (Anti-Drug Antibodies):
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1. Why didn’t the FDA’s Center for Biological Evaluation and Research require Moderna and Pfizer-BioNTech to conduct immunogenicity testing on their COVID-19 vaccines for anti-drug antibodies as recommended in the agencies’ own guidelines for drug development during clinical trials?
In January 2019, the U.S. Department of Health and Human Services, FDA, Center for Drug Evaluation and Research, and Center for Biologics Evaluation and Research issued a
document, “Immunogenicity Testing of Therapeutic Protein Products — Developing and Validating Assays for Anti-Drug Antibody (ADA) Detection: Guidance for Industry.”
The document, described as providing “recommendations to facilitate industry’s development and validation of essays for the assessment of the immunogenicity of therapeutic protein products during clinical trials,” clearly acknowledges the existence of anti-drug antibodies, such as
polyethylene glycol (PEG), in humans. The document states:
- Immune responses to therapeutic protein products have the potential to affect product pharmacokinetics, pharmacodynamics, safety and efficacy.
- The clinical effects of immune responses in subjects are highly variable, ranging from no measurable effect to extremely harmful.
- Detection and analysis of ADA formation is a helpful tool in understanding potential immune responses.
- Information on immune responses observed during clinical trials, particularly the incidence of ADA induction or any implications of ADA responses affecting pharmacokinetics, pharmacodynamics, safet, or efficacy is crucial for any therapeutic protein product development program.
- Accordingly, such information, if applicable, should be included in the prescribing information as a subsection of the ADVERSE REACTIONS section entitled Immunogenicity.
However, despite the FDA’s own guidance recommending that information about immunogenicity be included on the vaccine package inserts, no such information is included on either the
Pfizer-BioNTech or
Moderna COVID-19 vaccine inserts.
Page six of the FDA document cites
research that specifically addresses the need to “adequately understand the risk of anti-drug antibodies … in products with modifications such as pegylation.” But without that information provided on package inserts, vaccine recipients can’t understand those risks.
The rapidly developed and currently distributed
mRNA vaccines rely on a new nanoparticle-based “carrier system” that utilizes PEG. The lipid nanoparticles (LNPs) carrier system used in the two COVID-19 vaccines to facilitate the delivery of the mRNA into the cell is pegylated — which means, coated with PEG. Coating the lipid nanoparticle with PEG keeps it from degrading.
An
article published this year in
Advanced Drug Delivery Reviews reported:
“Conjugation of polyethylene glycols (PEGs) to proteins or drug delivery nanosystems is a widely accepted method to increase the therapeutic index of complex nano-biopharmaceuticals. Nevertheless, these drugs and agents are often immunogenic, triggering the rise of anti-drug antibodies (ADAs). Among these ADAs, anti-PEG IgG and IgM were shown to account for efficacy loss due to accelerated blood clearance of the drug (ABC phenomenon) and hypersensitivity reactions (HSRs) entailing severe allergic symptoms with occasionally fatal anaphylaxis.”
It is mystifying how a never-before-utilized vaccine technology that contained a synthetic, nondegradable and
increasingly controversial polymer (PEG) — known to be associated with adverse immune responses and the development of anti-drug antibodies — was allowed to bypass the bedrock of pharmaceutical development, which is immunological testing.
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The other 4 questions can be seen here:
As reports surfaced today of yet another healthcare worker who suffered a severe allergic reaction to Pfizer’s COVID vaccine, it’s time the FDA and Fauci explain what they plan to do about it.
childrenshealthdefense.org
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