FDA Forced to Retract Statements Saying Ivermectin Does Not Work Against COVID

[Leo123]

My horse refuses to take it.

That's why, for horses, they put it in a large syringe, idiot and if you can't properly worm your horse you shouldn't own it.

 

[The Irish Ram]

My horse refuses to take it.

lol. So does mine. I have to hide it in a cupcake...

 

[Moonglow]

lol. So does mine. I have to hide it in a cupcake...

Just like half the dogs don't want to chewable flea and tick chews.

 

[Leo123]

Just like half the dogs don't want to chewable flea and tick chews.

So, does that mean you shouldn't worm your pets? WTF are you even talking about?

 

[Moonglow]

That's why, for horses, they put it in a large syringe, idiot and if you can't properly worm your horse you shouldn't own it.

It comes in a drencher also.

 

[Moonglow]

So, does that mean you shouldn't worm your pets?

Why would I they don't have worms.

 

[Leo123]

Why would I they don't have worms.

Because it prevents worms as well.

 

[JackOfNoTrades]

You.
Are.
Lying.

The truth hurts. I know. But there are multiple studies out there showing the drug doesn't work.
But that does not stop you from taking it if your doctor prescribes it for you.
Deworm away!

Ivermectin still not effective or approved for COVID-19 treatment, FDA says

While some studies on ivermectin as COVID-19 treatment do exist and some do testify to the drug’s efficacy, that data is overwhelmingly considered inconsistent, questionable and/or inconclusive by …

thehill.com

 

[JackOfNoTrades]

Viruses are small obligate intracellular parasites, which by definition contain either a RNA or DNA genome surrounded by a protective, virus-coded protein coat. Viruses may be viewed as mobile genetic elements, most probably of cellular origin and characterized by a long co-evolution of virus and host.

Structure and Classification of Viruses - PubMed

Viruses are small obligate intracellular parasites, which by definition contain either a RNA or DNA genome surrounded by a protective, virus-coded protein coat. Viruses may be viewed as mobile genetic elements, most probably of cellular origin and characterized by a long co-evolution of virus...

pubmed.ncbi.nlm.nih.gov

COVID-19 is a virus. Not a parasite.
Just stop. You're embarrassing yourself.

 

[Leo123]

It comes in a drencher also.

We're discussing ivermectin for horses not sheep. You sure like to obfuscate.

 

[progressive hunter]

COVID-19 is a virus. Not a parasite.
Just stop. You're embarrassing yourself.

a virus is a parasite,,
so whats your qualifications for saying its not effective for covid??

 

[progressive hunter]

There's no lie in the truth.
Ivermectin is not effective in treating COVID-19.
It is effective in treating water and food borne parasites...which is what it's been approved for

But, you are free to deworm yourself. And your doctor can prescribe it for you if they believe it will help your COVID symptoms.

now that youve been given the proof your summation is incorrect do you retract this statement??

or are you going to dbl down??
if so please provide your credentials to back up your opinion,,

 

[Leo123]

COVID-19 is a virus. Not a parasite.
Just stop. You're embarrassing yourself.

You're an idiot

"Hypoalbuminemia is a frequent finding in patients with COVID‐19 and it also appears to be linked to the severity of lung injury [13]. Therefore, ivermectin could have sufficient bioavailability when used in such a setting."

The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review - The Journal of Antibiotics

Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms of action of ivermectin...

www.nature.com

The role of ivermectin against the SARS-CoV-2 virus​

The targets of activity of ivermectin can be divided into the following four groups:
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore.
B. Action on host targets important for viral replication
Level 4: Action as an antiviral.
Level 5: Action on viral replication and assembly.
Level 6: Action on posttranslational processing of viral polyproteins.
Level 7: Action on karyopherin (KPNA/KPNB) receptors.
C. Action on host targets important for inflammation
Level 8: Action on interferon (INF) levels.
Level 9: Action on Toll-like receptors (TLRs).
Level 10: Action on nuclear factor-κB (NF-κB) pathway.
Level 11: Action on the JAK-STAT pathway, PAI-1, that could be involved with COVID-19 sequalae.
Level 12: Action on P21 activated kinase 1 (PAK1).
Level 13: Action on interleukin-6 (IL-6) levels.
Level 14: Action on allosteric modulation of P2X4 receptor.
Level 15: Action on high mobility group box 1 (HMGB1).
Level 16: Action as an immunomodulator on lung tissue and olfaction.
Level 17: Action as an anti-inflammatory.
D. Action on other host targets
Level 18: Action on plasmin and annexin A2.
Level 19: Action on CD 147 on the red blood cell (RBC).
Level 20: Action on mitochondrial ATP under hypoxia on cardiac function.
The direct “antiviral targets” may be useful in the early stages while the anti-inflammatory targets might be addressed in the later stages of the disease.

 

[progressive hunter]

We're discussing ivermectin for horses not sheep. You sure like to obfuscate.

he likes sheep better than horses,,

easier to hold still,,

 

[JackOfNoTrades]

a virus is a parasite,,
so whats your qualifications for saying its not effective for covid??

A far better question is in the face of multiple studies saying this drug is not effective in treating COVID, why is this a hill you have picked to make your stand on?
This is actually a fascinating case study in human thought to me.

You people remind me of The People's Temple followers in the 70's. You'll swallow the Kool-Aid (ivermectin), no matter what effect it might have on you.

 

[JackOfNoTrades]

You're an idiot

"Hypoalbuminemia is a frequent finding in patients with COVID‐19 and it also appears to be linked to the severity of lung injury [13]. Therefore, ivermectin could have sufficient bioavailability when used in such a setting."

The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review - The Journal of Antibiotics

Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms of action of ivermectin...

www.nature.com

The role of ivermectin against the SARS-CoV-2 virus​

The targets of activity of ivermectin can be divided into the following four groups:
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore.
B. Action on host targets important for viral replication
Level 4: Action as an antiviral.
Level 5: Action on viral replication and assembly.
Level 6: Action on posttranslational processing of viral polyproteins.
Level 7: Action on karyopherin (KPNA/KPNB) receptors.
C. Action on host targets important for inflammation
Level 8: Action on interferon (INF) levels.
Level 9: Action on Toll-like receptors (TLRs).
Level 10: Action on nuclear factor-κB (NF-κB) pathway.
Level 11: Action on the JAK-STAT pathway, PAI-1, that could be involved with COVID-19 sequalae.
Level 12: Action on P21 activated kinase 1 (PAK1).
Level 13: Action on interleukin-6 (IL-6) levels.
Level 14: Action on allosteric modulation of P2X4 receptor.
Level 15: Action on high mobility group box 1 (HMGB1).
Level 16: Action as an immunomodulator on lung tissue and olfaction.
Level 17: Action as an anti-inflammatory.
D. Action on other host targets
Level 18: Action on plasmin and annexin A2.
Level 19: Action on CD 147 on the red blood cell (RBC).
Level 20: Action on mitochondrial ATP under hypoxia on cardiac function.
The direct “antiviral targets” may be useful in the early stages while the anti-inflammatory targets might be addressed in the later stages of the disease.

Then be a man, take your ivermectin if you get COVID, and let the rest of us know how it turns out.
Either way, stop bitching about it.

 

[progressive hunter]

A far better question is in the face of multiple studies saying this drug is not effective in treating COVID, why is this a hill you have picked to make your stand on?
This is actually a fascinating case study in human thought to me.

You people remind me of The People's Temple followers in the 70's. You'll swallow the Kool-Aid (ivermectin), no matter what effect it might have on you.

I dont understand the question,,

other studies say it has had some benefit,,

regardless you now know covid is a parasite and ivermectin treats parasites,,

it may not work for everyone,, but to say it wont work for anyone is not a hill I would make my stand on,, more so considering the mental illness you suffer from that has caused you to reject common sense and rational thought,,

 

[Leo123]

Then be a man, take your ivermectin if you get COVID, and let the rest of us know how it turns out.
Either way, stop bitching about it.

I just proved you wrong, be a man and admit it and stop spreading misinformation.

 

[progressive hunter]

Then be a man, take your ivermectin if you get COVID, and let the rest of us know how it turns out.
Either way, stop bitching about it.

we have already heard from many people and doctors saying it has helped,,

 

[JackOfNoTrades]

now that youve been given the proof your summation is incorrect do you retract this statement??

or are you going to dbl down??
if so please provide your credentials to back up your opinion,,

Son, there are multiple studies (peer reviewed) that have concluded that the drug is not effective in treating or preventing COVID-19.
But if you want to take the drug, you are free to do so if your doctor prescribes it for you.
That is ultimately what FDA settlement was about. The FDA overstepped its bounds and mocked the doctors publicly. THAT'S why they settled.
Not because they found to have lied about the drug's effectiveness.