This has already been tested and proven, again your bible bloggers don't provide the earth-shattering evidence you were praying for.
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis
You are missing the point but here is a good explanation.
Darwinism and the Deterioration
of the Genome
Jerry Bergman, Ph.D.
© 2005 by Creation Research Society. All rights reserved. Used by permission.
This article first appeared in Vol. 42, No. 2 of the Creation Research Society Quarterly,
a peer-reviewed journal published by the Creation Research Society.
Abstract
An evaluation of DNA/RNA mutations indicates that they cannot provide significant new levels of information. Instead, mutations will produce degradation of the information in the genome. This is the opposite of the predictions of the neoDarwinian origins model. Such genome degradation is counteracted by natural selection that helps maintain the status quo. Degradation results for many reasons, two of which are reviewed here. 1) there is a tendency for mutations to produce a highly disproportionate number of certain nucleotide bases such as thymine and 2) many mutations occur in only a relatively few places within the gene called “hot spots,” and rarely occur in others, known as “cold spots.” An intensive review of the literature fails to reveal a single clear example of a beneficial information-gaining mutation. Conversely, thousands of deleterious mutations exist, supporting the hypothesis that very few mutations are beneficial. These findings support the creation origins model.
Introduction
he primary basis of macroevolution is presumably the occurrence of mutations, which are accidental changes in the DNA. This includes both DNA that codes for protein and that which has other roles in the cell. This changed DNA can result in an observable change in the phenotype (the physical appearance) of the organism. These mutations ultimately provide the differences that are selected for (or against) by natural selection (Mayr, 2001; Wise, 2002, p. 163). The critical importance of mutations in providing the raw material for evolution is widely acknowledged by Darwinists, and is almost universally mentioned in biology textbooks (Mayr, 2001). In the words of one of the founders of the modern neoDarwinian theory, and one of the most eminent evolutionists, Harvard professor Ernst Mayr: “Ultimately, all variation is, of course, due to mutation” (Mayr, 1967, p. 50). The primary architect of neoDarwinism was Theodosius Dobzhansky who wrote that “the process of mutation is the only source of the raw materials of genetic variability, and hence of evolution” (Dobzhansky, 1957, p. 385, emphasis mine). Dobzhansky concluded that “evolution is possible only because heredity is counteracted by another process opposite in effect—namely, mutation” (1951, p. 25, emphasis mine). The conclusion that mutations are the key to evolution is the basis of modern neoDarwinism (Mayr, 2001).
Other sources of variation, such as sexual reproduction, genetic crossing over, and transposition, primarily produce only rearrangements of existing information and do not create new genetic information. These other mechanisms of change yield phenotypic variations that will produce, at best, only a limited amount of microevolution. Therefore, the source of all genetic variety required for macroevolution ultimately is mutations.
One of the most commonly utilized illustrations to help understand the process macroevolution via mutations was developed by the leading evolutionary biologist and Oxford professor, Richard Dawkins (1986). His example requires random variations of all, or almost all, of the nucleotides for neoDarwinian evolution to occur. This paper examines whether or not this general requirement is fulfilled.
The Dawkins macroevolutionary model actually helps to show why mutations that are expressed virtually always result in loss of information or corruption of the gene. Most all expressed mutations yield proteins that have reduced function, such as illustrated by sickle cell anemia. Some mutations, like adrenoleukodystrophy, cause a complete loss of function (Lewis, 2003, p. 26). This result fits with Batten’s report that most mutations are harmful and
most of the remainder seem to have neither positive nor negative effect. Mutations that are actually beneficial are extraordinarily rare and involve insignificant changes. Mutations seem to be much more degenerative than constructive... (Batten, 2002, p. 163).
Three kinds of mutations can be distinguished—beneficial, neutral, or deleterious (Mayr, 2001, p. 98). To be consistent, Mayr’s terminology will be used in this paper, which argues that the long term result of mutations is the degradation, deterioration, or degeneration of the genome.
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Jerry Bergman has seven degrees, including in biology, psychology, and evaluation and research, from Wayne State University, in Detroit, Bowling Green State University in Ohio, and Medical College of Ohio in Toledo. He has taught at Bowling Green State University, the University of Toledo, Medical College of Ohio and at other colleges and universities. He currently teaches biology, microbiology, biochemistry, and human anatomy at the college level and is a research associate involved in research in the area of cancer genetics. He has published widely in both popular and scientific journals
- Darwinism and the Deterioration of the Genome -- TrueOrigin Archive
he is the one that single handedly destroyed Neo Darwinism.
