Recalling that Princess Diana's chaffeur was taking albenazole at the time of death, ivermectin connects with decanoyl-RVKR chlormethylketone (post #2,039) and a 22-month-old Native American girl infected with Onchocerca in Arizona. Worobey (post#2,042) is in Arizona and can't pretend not to know. Has Worobey taken up the recent challenge for public debate posed by Dr. Quay?
Mar 2013 Arizona Native American / Onchocerca
'....has been reported from dogs and cats in western United States....albendazole....however, because ivermectin is known to kill the larvae of O. volvulus and to accelerate the death of adult worms when given 2-4 times per year, the regimen was changed to ivermectin.'
A vaccine does not exist for O. volvulus. The implicated von Willebrand factor will link to other furin-like motifs including those for hantaviruses (Prospect Hill Virus, Maryland; Jemez Springs Virus, New Mexico, Rockport Virus, Texas, etc.).
Onchocerca volvulus Bli Protein
uniprot.org
'....Activity Regulation: Inhibited by the peptide before the second cleavage. Inhibited by ethylenediaminetetraacetic acid (EDTA), ZnSO4, and chloroketone DEC-RVKR-CMK.
....
84-90 RSRRRKR....109-117 RPRVRRKRD....(glycine zipper) 322-330 RGVKAGRGG....667-670 RDSR....'
The extra arginine (R) in 109-117, ( RVKRR, differing from the target RVKR) likely increases activity due to its furin-like composition.
Therefore, the zoonotis (Holmes, Worobey, Rasmussen, etc.) argument for ivermectin's use in scabies for raccoon dogs or civet cats is only a surface argument (host integument for Sarcoptes) when one looks more closely at the blood work (von Willebrand, thrombospondin, complement, etc.)