Despite efforts to internationally isolate Syria, especially during the Bush era, it has reasserted itself as a central player in the Middle East. Following the assassination of Lebanese prime minister Rafik Hariri in 2005, the US withdrew its ambassador to Beirut, intensified sanctions against Damascus and sought to deepen Syria’s isolation from the international community. The recent array of high-level visitors to Damascus – including US officials – demonstrates that President Bashar Assad has weathered the storm of isolation and has emerged as an essential actor in resolving regional disputes, including the Israeli-Palestinian conflict. Israel should now respond favorably to Syria’s call for renewed peace talks, and in so doing utilize its influence to advance peace, rather than thwart it.