A Leopold Trajectory

Discussion in 'Healthcare/Insurance/Govt Healthcare' started by badger2, Jan 24, 2018.

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    Daily Cardinal, Spring Welcome Back Issue, 2018 Trump's Censorship is Authoritative, Harmful
    'Fetus. Diversity. Transgender. Vulnerable. Entitlement. Science-based. Evidence-based. These are all words that the Trump administration has chosen to ban from the budget proposals of the Center for Disease. While the Department of Health and Human Services claims that no list of banned words exists, it is easy to understand the implication directed towards CDC employees: there may not be an official list, but using those particular words in your proposals will get you in trouble. CDC employees who like their jobs will undoubtedly refrain from putting these newly proclaimed buzz-words in their reports.'

    Proving that the Leopold Trajectory thread is correctly placed here on the Healthcare forum, is this Ap 2016 CDC report:

    Haematospirillum (Rhodospirillaceae) / Human Blood Isolate
    Haematospirillum jordaniae gen. nov., sp. nov., isolated from human blood samples. - PubMed - NCBI

    Novispirillum (previously Azospirillum itersonii, previously Spirillum itersonii) shows aminolevulinic acid linked to healthcare grasses of New Mexico (and elsewhere) mentioned in this thread, used as a topical to kill basal cell carcinoma, and this closely-related chemistry occurring (inside [italics]) the human body via this organism.

    Future New Mexico CCC workers may include not only stream-bank erosion control workers, but also more technically savvy workers that look for sampling areas and micro-habitats for the conservation of natural resources.
     
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    H. jordaniae is named for Jean Jordan (The Candy Lady), an unsung heroine of the CDC, which will sooner or later link with our development of a Japanese alphabet: the first example of the alphabet will be used in conjunction with Jean Jordan's counterpart, Yasuke Terasaki, from the Suzugamine Women's College in Hiroshima.
     
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    Here is an example of coming close to using a taboo buzz-word: 'Overexpression of shh (human HH Drosophila homologue) in transgenic mice induces features of basal cell carcinoma."

    A decent site for medical browsing that includes a near-taboo word such as "evidence-based":
    www.senseaboutscience.org

    This is a cutting-edge article proving the cost-effective approach that opposes surgery via photodynamic therapy for basal cell carcinoma, further reinforcing the Leopold trajectory:

    Jan 2018 Spain / BCC
    Comparison of treatment of basal cell carcinoma between surgery and intralesional photodynamic therapy: a cross-sectional study. - PubMed - NCBI
     
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    For a basal cell carcinoma example, healthcare costs depend on the type of lesion, amongst other factors such as arsenic ingestion which is environmental. The risk seems to be accumulative ultraviolet radiation in childhood (an Italian study), not adulthood. A study in the Netherlands showed that the incidence of bcc in transplant patients was 10 times higher than in the general population.

    Basal Cell Carcinoma
    doi: https://doi.org/10.1136/bmi.327.7418.794
    '....The overall age and sex standardised annual incidence in Minnesota, USA, was reported at 1246 per 100,000. In Australia, the incidence is much higher at 726 per 100,000. In white populations in North America, the incidence has increased at more than 10% a year, leading to a lifetime risk of 30% of developing basal cell carcinoma. With an ever-increasing elderly population, the disease is likely to become more of a problem in the future. Indeed, the prevalence of this cancer will probably be greater than that of all other cancers combined.
    ....
    Skin type 1 (always burns, never tans), red or blonde hair, and blue or green eyes have been shown to be risk factors, with an estimated odds ratio of 1.6. Recreational sun exposure in childhood seems to be an important risk factor, an Italian study calculated an almost five-fold increase in risk for an average summer holiday exposure of more than eight weeks throughout childhood (before the age of 20 years).. Outdoor occupation after the age of 20 years was not associated with an increased risk of bcc. This suggests that childhood and adolescence may be critical periods for establishing adult risk for bcc and may explain why studies have failed to find a large impact of increased cumulative sun exposure in adulthood on the risk of bcc.
    ....
    A recent study looking at the use of sunbeds by young women with bcc has shown a non-significant (P= 0.351) increase in the average number of lifetime tanning bed exposures compared with the control population.
    ....
    The most important clinical subtype is the morphoeic basal cell carcinoma. These have a more aggressive natural history and ill-defined borders, making complete excision under direct vision difficult. These types of basal cell carcinoma can be difficult to diagnose clinically and often present late. Some of these tumours can be huge and devastating to the patient, needing lengthy plastic surgical reconstructions and causing much cosmetic disfigurement. They account for approximately 5% of all basal cell carcinomas.

    The risk of developing a squamous cell carcinoma is increased slightly after a basal cell carcinoma, with a 6% risk at three years. Patients are at increased risk of developing malignant melanomas -- an American study showed a multivariate risk of 2.2, a Danish study found a standardised incidence ratio of 2.64, and a Swedish study showed a six-fold increase in men developing malignant melanomas after a diagnosis of basal cell carcinoma and a four-fold increase in women. This risk is presumably related to exposure of ultraviolet radiation.'
     
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    should read 146 per 100,000
     
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    Future conservation corps work may monitor Aldo Leopold's "conditions in the field." Botulism-causing genus, Clostridia links to spirillum-like organisms associated with grass roots:

    '....spirilla-like rods containing numerous lipid bodies which usually made up more than 80% of the culture. No Azotobacter, Beijerinckia, ad very few Clostridia were seen. The latter were more frequent and sometimes became dominant in earlier attempts, where test tubes with 5ml medium in a 7cm layer were used.'
    (Dobereiner J, Day JM, Associative Symbioses in Tropical Grasses: Characterization of Microorganisms and Dinitrogen-Fixing Sites)
     
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    Linking to Yasuke Terasaki's Japanese spirillae to spirillae in the Aldo Leopold Wilderness grasses expedition is the Clostridium connection we have already shown for botulism in avians. This toxin, however, further links aminolevulinic acid produced by these spirilla to brain cancer.

    The aminolevulinic acid connection is on chromosome 1p36.2

    Neuroprotective 5-Aminolevulinic Acid / Neuroblastoma
    Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells. - PubMed - NCBI

    The botulin toxin connection is on chromosome 1p36.1

    Botulin Toxin Treatment of Schwartz-Jampel Syndrome
    Botulinum toxin A injections for the treatment of Schwartz-Jampel syndrome: a case series. - PubMed - NCBI
     
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    We tracked the first Spirillum genus through name changes, arriving at Novispirillum itersonii itersonii ATCC 12639. The genome has been sequenced, and is shown at JGI, verified as producing 6-aminolevulinate synthase (EC 2.3.1.37).

    If this organism occurs in New Mexico, and especially in Gila or Aldo Leopold Wilderness, then Leopold's "field conditions" for grasses (1909) take on fresh implications for future research. ATCC 12639 also links to CDC's human pathogen, Haemaspirillum, which genome is not yet available.
     

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