It has been used ever since we became a nation to isolate people who might have an infectious disease and all courts have used the commerce clause as the base of being able to do so since 1776.
But it does not erase 4th amendment rights.
The 4th amendment pertains to any criminal law not contagious illnesses.
No! It pertains to everything! Every single kind of search and/or seizure. It does not matter what the government's goal may be. The right of the people to be secure in their person from unreasonable seizure shall not be infringed. Period! That's why the government is required to have probable cause for an involuntary hold in a psychiatric facility. That's a health issue too.
As I've pointed out to you so many times already, just because quarantines are a generally legal does not mean that all actions of quarantine are legal. There has never been any probable cause to indicate that Kaci Hickox was infected with Ebola. Your "maybe" argument is no different than arresting someone who owns a gun because "maybe" they'll kill someone with it. It's bullshit there, and it's bullshit here.