Note that now we have a strong link to both monoclonal antibody therapy and Johnson and Janssen vaccine for the (Janssen) origin of fentanyl. We call K417N/T the “fentanyl mutation.” J&J’s Janssen Pharmaceutica, Belgium, and here is the report from Belgium that indeed links these antibody mutations to the opioid receptor:
Oct 2011 Belgium Asn230 Mu-Opioid Receptor
Oct 2011 Belgium Asn230 Mu-Opioid Receptor
The role of the hydrophilic Asn230 residue of the mu-opioid receptor in the potency of various opioid agonists - PubMed
1. To investigate the effect of the hydrophilic Asn amino acid at position 230 of the human mu-opioid receptor (hMOR230) on the potency of various agonists, we mutated this residue to Thr and Leu (hMORN230T and hMORN230L respectively). 2. Taking advantage of the functional coupling of the opioid...
pubmed.ncbi.nlm.nih.gov