Dengue Spread From Mexico to Arizona; Local Transmission Feared

[Disir]

Medscape: Medscape Access


Mosquitoes are natures little terrorists.

 

[ScienceRocks]

And you can bet that the republicans won't do a fucking thing!

 

[Disir]

And the Democrats will do something really important. For example, blame the Republicans. Therefore, nothing gets done ever. How cool is that?

 

[Ringel05]

Here's the CDC link. You don't have to create an account to view it.

Binational Dengue Outbreak Along the United States–Mexico Border — Yuma County, Arizona, and Sonora, Mexico, 2014 | MMWR

 

[Ringel05]

And you can bet that the republicans won't do a fucking thing!

Hack.......

 

[Disir]

In Arizona, suspected dengue cases are reported by health care providers and commercial laboratories. When possible, specimens from suspected dengue cases at commercial laboratories are forwarded to CDC Dengue Branch for confirmatory testing by real time RT-PCR (rRT-PCR) for detection and typing of DENV, and by anti-DENV IgM ELISA.

And that right there is why the US is never on the ball and only knows a portion of what is going on and WHERE it is going on. There is no mandatory reporting to the CDC.

 

[waltky]

Side effect of dengue fever vaccine Could Cause Severe Illness...

Dengue Fever Vaccine Could Cause Severe Illness
September 01, 2016 - The first vaccine marketed to prevent dengue fever could be making people sick, according to a new study. The authors are urging public health officials to consider carefully which individuals to vaccinate, to prevent severe illness.

An estimated 400 million people globally are infected each year with dengue fever, a mosquito-borne virus found most often in tropical regions. People who live in dengue-prone areas frequently are infected more than once, but most suffer relatively mild symptoms, including fever. However, more than 2 million people each year develop a severe hemorrhagic case of the disease, which can be fatal. Dengue is more severe the second time a person gets infected. About 25,000 people a year die as a result of the infection. So when Dengvaxia — the first and, so far, only vaccine against dengue — was approved by regulators, there was much excitement.

A dengue fever victim receives medical treatment at a health center in Managua, Nicaragua​

Infections cut sharply

Large clinical trials — involving approximately 10,000 children, ages 2 to 14 — were conducted in Southeast Asia and in Latin America. Phase-three trials involved about 21,000 youngsters between the ages of 9 and 16. Researchers found the Dengvaxia vaccine, made by pharmaceutical company Sanofi-Pasteur, reduced the number of infections by 60 percent and hospitalizations by 80 percent. But as time went on, many of those who had been vaccinated, including the younger children, fell seriously ill with dengue. Researchers at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Imperial College London and the University of Florida analyzed data from all of the vaccine trials, involving more than 30,000 people in 10 countries, with long-term follow-up of the participants.

Vietnamese parents look after their children in a room designated for the treatment of dengue fever at Ho Chi Minh City's pediatric hospital​

One of the study’s lead authors, Isabel Rodriguez-Barraquer of the Bloomberg school, said it appears the vaccine acts as a silent, first infection in some people. “What seems to be happening with this vaccine is that those people who have never seen dengue in the past, that have never been infected in the past, if they get vaccinated, let’s say the vaccine acts like their first infection, right? So, if they ever get a second infection, or a true first infection, it would be more severe than it would have been, right? And that’s the concern,” said Rodriguez-Barraquer. That may explain why young children, many under the age of 9, were getting severely ill. They hadn’t lived long enough to get a first infection.

WHO directive

 

[waltky]

Cause of Severe Form of Dengue Fever Found...

Scientists: Cause of Severe Form of Dengue Fever Found
January 27, 2017 The cause of a severe form of dengue fever has been identified. The finding offers the possibility of earlier lifesaving care and the development of drugs to treat the tropical illness.

Experts say one third of the world’s population lives in countries where dengue fever is endemic. It is caused by the bite of a mosquito that harbors the dengue virus. There are four varieties or stereotypes of the virus. The symptoms — fever, body aches and malaise — can be relatively mild the first time a person is infected. A second infection, however, can be life-threatening. It can cause a hemorrhagic form of the disease, leading to severe bleeding and death. The question for scientists is, “why?”

The findings

An international team led by Jeffrey Ravetch found that it has to do with protective antibodies that are produced by the body’s immune system when exposed to dengue a second time. “If they are not able to neutralize the viral strains, but not seeing the right structures on the virus or if they are not in a high enough concentration called a titer, then instead of protecting, they actually enhance disease," said Ravetch, head of the molecular genetics and immunology lab at Rockefeller University in New York. "They can do that because the antibodies actually will bind to the virus instead of eliminating the virus," he explained. "They actually aid the virus in infecting cells.” The phenomenon is called antibody-dependent enhancement or ADE.

A health ministry worker fumigates a house to kill mosquitoes during a campaign against dengue and chikungunya and to prevent Zika infection in Managua, Nicaragua​

Ravetch and an international team of scientists identified a sign or signature of the misdirected antibodies that can lead to hemorrhagic dengue. The finding was published in the journal Science. “So it can be a diagnostic tool," he said. "We know who is at risk. We can see the patients coming in [to the hospital] with dengue fever and say, 'Gee, you’re at risk to develop hemorrhagic fever. You can get really sick.' So, we can take preventive measures. We can put you into a more intensive care-like environment. We can make sure your fluids are controlled. If we can do better care for these patients, you know, waiting for them to come in with shock.” There is currently no treatment for severe dengue, only supportive care.

Viable vaccines