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Compound LJ001 Acts Like Antibiotic Against Viruses | Popular Science
Unlike antibiotics, which kill many different types of bacteria, antiviral drugs for the most part need to target individual, specific viruses. A drug that attacks a multitude of viruses -- an antibiotic for viruses, effectively -- would be a significant boon for medicine. And a group of researchers led by UCLA scientists just may have discovered exactly that.
Writing in Proceedings of the National Academy of Sciences, the researchers describe an early proof-of-concept study on a chemical they call LJ001. The chemical attacks the structure of viruses themselves, and may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola.
For all the complexity of the diseases they cause, viruses are very simple; just a bunch of DNA in a lipid sack. LJ001 attacks that lipid sack, as well as the lipid membrane of healthy cells. But whereas the healthy cells can easily repair the damage, the inert viruses simply fall apart.
Many bacteria have developed resistance to penicillin, but that doesn't make the discovery any less significant.Don't get too carried away. Viruses have a way of willing themselves past these temporary obstacles. Enjoy it while it lasts, but it's not permanent
Compound LJ001 Acts Like Antibiotic Against Viruses | Popular Science
Unlike antibiotics, which kill many different types of bacteria, antiviral drugs for the most part need to target individual, specific viruses. A drug that attacks a multitude of viruses -- an antibiotic for viruses, effectively -- would be a significant boon for medicine. And a group of researchers led by UCLA scientists just may have discovered exactly that.
Writing in Proceedings of the National Academy of Sciences, the researchers describe an early proof-of-concept study on a chemical they call LJ001. The chemical attacks the structure of viruses themselves, and may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola.
For all the complexity of the diseases they cause, viruses are very simple; just a bunch of DNA in a lipid sack. LJ001 attacks that lipid sack, as well as the lipid membrane of healthy cells. But whereas the healthy cells can easily repair the damage, the inert viruses simply fall apart.
This could be the biggest discovery in medicine since the development of penicillin. Most impressively, LJ001 successfully cured mice of ebola, one of the most lethal diseases known to man, without any side effects.
The downside? It only works on lipid-enveloped viruses.
The UCLA Aids Institute has already applied for a patent on the compound.
Many bacteria have developed resistance to penicillin, but that doesn't make the discovery any less significant.Don't get too carried away. Viruses have a way of willing themselves past these temporary obstacles. Enjoy it while it lasts, but it's not permanent
Even better, the compound — a rhodanine derivative that the researchers have dubbed LJ001 — could be effective against new, yet-to-be discovered enveloped viruses.
we shall see, but if the history of 'discoveries' of anti-viral therapy and cures is to be taken into consideration---I'd bet against the hype and the press releasesLee and his collaborators developed their concept of LJ001 as interfering only with enveloped viruses after testing 23 pathogens in cell culture. Studies of nine of those agents — including Ebola virus, Nipah virus and Rift Valley fever virus — required high- or maximum-containment facilities and were carried out in the biosafety level 3 and 4 laboratories of the University of Texas Medical Branch at Galveston (UTMB) and USAMRIID.
"Once we started testing more and more, we figured out that it was only targeting the enveloped viruses," said Alexander N. Freiberg, director of UTMB's Robert E. Shope, M.D., Laboratory.
The Shope BSL4 lab was also used for mouse experiments with Ebola and Rift Valley fever virus that further confirmed the protective value of LJ001.
While the exact mechanism of viral membrane inactivation is unknown, the researchers are pursuing some promising leads that could answer that question.
Additionally, the drug does not appear to be toxic in vitro or in animals when used at effective antiviral concentrations.
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UCLA has filed for a patent on the use of the compound. The study is available in Proceedings of the National Academy of Sciences at A broad-spectrum antiviral targeting entry of enveloped viruses ? PNAS.
In layman's terms, that means what, as far as application and effectiveness are concerned?The downside? It only works on lipid-enveloped viruses.
.
This could be the biggest discovery in medicine since the development of penicillin. Most impressively, LJ001 successfully cured mice of ebola, one of the most lethal diseases known to man, without any side effects.Compound LJ001 Acts Like Antibiotic Against Viruses | Popular Science
Unlike antibiotics, which kill many different types of bacteria, antiviral drugs for the most part need to target individual, specific viruses. A drug that attacks a multitude of viruses -- an antibiotic for viruses, effectively -- would be a significant boon for medicine. And a group of researchers led by UCLA scientists just may have discovered exactly that.
Writing in Proceedings of the National Academy of Sciences, the researchers describe an early proof-of-concept study on a chemical they call LJ001. The chemical attacks the structure of viruses themselves, and may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola.
For all the complexity of the diseases they cause, viruses are very simple; just a bunch of DNA in a lipid sack. LJ001 attacks that lipid sack, as well as the lipid membrane of healthy cells. But whereas the healthy cells can easily repair the damage, the inert viruses simply fall apart.
The downside? It only works on lipid-enveloped viruses.
The UCLA Aids Institute has already applied for a patent on the compound.
You're not too bright, You missed what is the most pertinent part of the hyped up story: "...may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola"
May. Potentially.
I've seen this kind of nonsense rear it's head in headlines since the days... with a local hospital and with a study sponsored by and monitored by the State of MA., and Harvard University.
influenza...AIDS...Ebola: I don't know enough about influenza... and Ebola---all die of it....HIV/AIDS. It resides in the cells of people infected with it. It crosses the blood brain barrier. I don't see how this 'may' potentially' rises to serious consideration of a discussion of a cure for HIV/AIDS.
☭proletarian☭;2213209 said:This could be the biggest discovery in medicine since the development of penicillin. Most impressively, LJ001 successfully cured mice of ebola, one of the most lethal diseases known to man, without any side effects.
The downside? It only works on lipid-enveloped viruses.
The UCLA Aids Institute has already applied for a patent on the compound.
You're not too bright, You missed what is the most pertinent part of the hyped up story: "...may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola"
May. Potentially.
I've seen this kind of nonsense rear it's head in headlines since the days... with a local hospital and with a study sponsored by and monitored by the State of MA., and Harvard University.
influenza...AIDS...Ebola: I don't know enough about influenza... and Ebola---all die of it....HIV/AIDS. It resides in the cells of people infected with it. It crosses the blood brain barrier. I don't see how this 'may' potentially' rises to serious consideration of a discussion of a cure for HIV/AIDS.
Nobody has ever died from AIDS
So healthy cells would repair themselves, would that mean unhealthy cells, say like cancerous cells, wouldn't?
I've read the PNAS article, and this series of studies is sound. They've already followed up with animal studies, and the results thus far are positive.You're not too bright, You missed what is the most pertinent part of the hyped up story: "...may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola"
May. Potentially.
I've seen this kind of nonsense rear it's head in headlines since the days... with a local hospital and with a study sponsored by and monitored by the State of MA., and Harvard University.
As stated in the journal article, it integrates into and prevents the fusion of viral lipid membranes to mammalian cells.influenza...AIDS...Ebola: I don't know enough about influenza... and Ebola---all die of it....HIV/AIDS. It resides in the cells of people infected with it. It crosses the blood brain barrier. I don't see how this 'may' potentially' rises to serious consideration of a discussion of a cure for HIV/AIDS.
☭proletarian☭;2213208 said:In layman's terms, that means what, as far as application and effectiveness are concerned?The downside? It only works on lipid-enveloped viruses.
.
A group of researchers led by a team from UCLA and including others from the University of Texas at Galveston, Harvard University, Cornell University and the United States Army Medical Research Institute of Infectious Diseases may have found just such a compound.
In a proof-of-principle study published online in Proceedings of the National Academy of Sciences, the researchers have identified an antiviral small molecule that is effective against numerous viruses, including HIV-1, influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses and flaviviruses. These viruses cause some of the world's deadliest diseases, such as AIDS, Nipah virus encephalitis, Ebola, hemorrhagic fever and Rift Valley fever.
Even better, the compound a rhodanine derivative that the researchers have dubbed LJ001 could be effective against new, yet-to-be discovered enveloped viruses.
For all the complexity of the diseases they cause, viruses are very simple; just a bunch of DNA in a lipid sack. LJ001 attacks that lipid sack, as well as the lipid membrane of healthy cells. But whereas the healthy cells can easily repair the damage, the inert viruses simply fall apart.
So healthy cells would repair themselves, would that mean unhealthy cells, say like cancerous cells, wouldn't?
Are cancer cells viruses?
It means it doesn't work on all viruses, just a certain type.☭proletarian☭;2213208 said:In layman's terms, that means what, as far as application and effectiveness are concerned?The downside? It only works on lipid-enveloped viruses.
.
As cancer cells are immortal, and able to heal themselves far faster than normal human cells, this treatment is completely useless against most tumors.Course not. But that doesnt really answer my question does it? I'd like to know what it does to cancer cells as they are unhealthy.
You aren't curious at all?
I've read the PNAS article, and this series of studies is sound. They've already followed up with animal studies, and the results thus far are positive.You're not too bright, You missed what is the most pertinent part of the hyped up story: "...may potentially cure a wide swath of disease ranging from influenza to AIDS to Ebola"
May. Potentially.
I've seen this kind of nonsense rear it's head in headlines since the days... with a local hospital and with a study sponsored by and monitored by the State of MA., and Harvard University.
A broad-spectrum antiviral targeting entry of enveloped viruses : PNAS
As stated in the journal article, it integrates into and prevents the fusion of viral lipid membranes to mammalian cells.influenza...AIDS...Ebola: I don't know enough about influenza... and Ebola---all die of it....HIV/AIDS. It resides in the cells of people infected with it. It crosses the blood brain barrier. I don't see how this 'may' potentially' rises to serious consideration of a discussion of a cure for HIV/AIDS.
If viral particles cannot fuse to mammalian cells, they cannot spread, and so can be eliminated through the normal turnover of cells. HIV infects T-cells, and so to hypothetically cure HIV, you need only flood the blood and lymph with a combination of LJ001 and the cytokines which induce T-cell turnover (such as TNF).
And these particles are far too small to be hindered by the blood-brain barrier.
As cancer cells are immortal, and able to heal themselves far faster than normal human cells, this treatment is completely useless against most tumors.Course not. But that doesnt really answer my question does it? I'd like to know what it does to cancer cells as they are unhealthy.
You aren't curious at all?
Sorry.
