COVID-19’s Biological Politics

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A highlight of the origins debate video (post #1, 216) beginning @ timepoint 1:05 links coronavirus in Malacomys near Quesso as well as HIV/SIV for HIV origins (SIV infection in Pan troglydytes schweinfurthii, westernmost range across the river from Quesso). Thus the inhibitor Charles is talking about in the video links the pharmacology to Anne Rimoin / PREDICT Malacomys African coronavirus, just as the Malacomys African monkeypox links Metabiota.

 

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Along current political lines is the Cullen page investigating influenza stats:

https://twitter.com/I_Am_JohnCullen

 

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In the origins video (post #1,216), Charles Rixey's Prometheus Shrugged site is accompanied by identity booby-trapping, so is not recommended, even though Rixey's argument for fusion inhibitors is compelling.

 

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The same video, above, mentions Leo Biddle, thus linking the Malacomys coronavirus-SIV-monkeypox trajectory:

Leo Biddle, Gorilla in the Coalmine / Timepoint 10:38, "Coronavirus outbreak in chimpanzees in 2016.'

 

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RGD motif was mentioned in Post #1,214. Here we link Quay's rgd motif to Angie Rasmussen (U. Saskatchewan, MBI Adj. Prof.)

Quay's rgd motif post can be seen: ' Bat_CoV_ZC45: rgdp'

The Angie Rasmussen link to rgd is here:
2009 U. Saskatchewan, Canada / RGD Motif

The role of RGD-tagged helical rosette nanotubes in the induction of inflammation and apoptosis in human lung adenocarcinoma cells through the P38 MAPK pathway - PubMed

The rosette nanotubes (RNTs) are a class of biologically inspired, self-assembling, metal-free, hydrophilic nanotubes, which hold tremendous potential as targeted drug delivery vehicles. We investigated the cell signaling events caused by lysine-functionalized RNTs (K-RNT) co-assembled with...

pubmed.ncbi.nlm.nih.gov

Because the RGD motif also links to the largest human gene, dystrophin, of muscular dystrophy, we will expound further on the RGD motif shown on Quay's Twitter page. Note that the RGD motif in ZC45 occurs just before a 3-amino acid deletion, and there are also deletions in the dystrophin gene. Quay just recently brought up the bat virus from Zhoushan Island, ZC45:

https://twitter.com/Quay_dr

 

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First week of October, Quay mentions D614, though seems to fail in linking it to Fau Chi's video where Fau gets this mutation backwards. Quay seems also to fail to link this precise mutation to VSV-based ebola vaccine. This is a gain-of-function mutation that (increases [italics]) Vesicular Stomatitis Virus pseudoparticles.

 

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Once again, the spike sequence for ZC45 can be retrieved by scrolling back to 24 Aug on Dr. Quay's Twitter page. As will be shown, the muscular dystrophy gene links the RGD motif to osteopontin, though there are problems with Dr. Quay's ZC45 virus. One problem is the wrong bat, the mistake in reporting seems to belong to the Wuhan Hospital's report:

May 2020 / Wuhan jinyintan Hospital / 5 Patients

Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study - PubMed

A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.

pubmed.ncbi.nlm.nih.gov

'....Five patients were admitted to the Wuhan Jinyintan Hospital from December 18 to December 29, 2019....The virus is phylogenetically closest to a bat SARS-like CoV (SL-ZC45, GenBank MG 772933)....male, 61, chronic liver disease....death....Chinese horseshoe bats, Rhinolophus sinicus.'

But ZC45 comes from R. pusillus, not R. sinicus, and the difference will be important when investigating the muscular dystrophy links to the RGD motif:

Rhinolophus pusillus SL-CoVZC45 Spike Protein

Bat SARS-like coronavirus isolate bat-SL-CoVZC45, complete genome - Nucleotide - NCBI

'....collected Feb 2017, Institute of Military Medicine, Nanjing Command....RGDPMPNNGW.'

Unlike Quay's posted ZC45 sequence, there are no deletions shown for MG772933 collected by the Chinese military.

Quay's sequence: RGDP---MPNNGW

 

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So, not far from Ralph Baric's Chapel Hill lab is the Fau Chi connection to dog experiments and muscular dystrophy in golden retrievers:

ZC45 was collected in Feb 2017, and the date is Dec 2017.
AKT / Duchenne Muscular Dystrophy

Osteopontin is linked with AKT, FoxO1, and myostatin in skeletal muscle cells - PubMed

OPN may interact with AKT1/MSTN/FoxO1 to modify normal and dystrophic muscle. Muscle Nerve 56: 1119-1127, 2017.

pubmed.ncbi.nlm.nih.gov

'....RGDS blocking peptide showed similar effects to the AKT inhibitor....dogs were housed either at the University of Missouri (Institutional Animal Care and Use Committee No. 2435), or the University of North Carolina at Chapel Hill (Institutional Animal Care and Use Committee No. 06-338.0).

The manipulation of amino acids in the above report links to another strain of virus from the same bat, R. pusillus:

Rhinolophus pussilus SL-CoVZXC21 Spike Protein

Bat SARS-like coronavirus isolate bat-SL-CoVZXC21, complete genome - Nucleotide - NCBI

'....collected Jul 2015, Institute of Military Medicine, Nanjing Command....RGDPMSNNGW.'

As can be seen by comparing both R. pusillus strains, there is a proline-serine difference in the spike sequences. Thus, the earlier 2015-collected virus has the serine found in the RGDS AKT-blocking peptide for Duchenne muscular dystrophy dogs linked to Baric's lab at Chapel Hill.

For those who have been with this thread from the beginning, it is well documented that the Chinese krait, Bungarus, was suspect intermediate host at one time in the media, as well as we having shown the 17-fold increase in this snake's venom in connection with chloroquine (the Ft. Detrick study).

Taiwan / RGD / Bungarotoxin

Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation - PubMed

The B chain of beta-bungarotoxin 1-6 sequence, RGRHGD, presents the highest local average hydrophilicity measured by Kyte and Doolittle modeling analysis. The RGRHGD holds parts of both RGD and KGD peptides, which have been reported as having high binding affinity to GPIIb-IIIa. The present...

pubmed.ncbi.nlm.nih.gov

'....The RGRHGD holds parts of both RGD and KGD peptides, which have been reported as having high binding affinity to glycoprotein IIb-IIIa (integrin alpha IIb-beta3), a well characterized membrane receptor of platelets....beta-bungarotoxin, consisting of the A & B chain, has been demonstrated to have distinct phospholipase A2 and neurotoxin activity. We analyzed and synthesized the RGRHGD, the highest local hydrophilicity region of the B chain.'

 

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The latest anti-zoonoti origins report is here:

12 Oct 2022
Investigators Challenge Claims That COVID-19 Began in the Huanan Seafood Market

Investigators challenge claims that Covid-19 began in the Huanan seafood market

A group of independent investigators and scientists have produced a new report in which they challenge claims that SARS-CoV-2 emerged from the Huanan seafood market in Wuhan via zoonosis. The repor…

www.changingtimes.media

Towards the end of this report is the statement, ' "No independent, transparent, and science-based investigation has been carried out regarding the bioengineering of SARS-like viruses that was underway before the outbreak of COVID-19." '

The above statement is highly misleading, and we note that as far as is known, none of these people have mentioned Sorensen, et al. At least as early as Jan 2022, we posted to USMB this stunning report:

Sorensen, et al

https://www.minervanett.no/files/2022/07/13/TheEvidenceNoNaturalEvol.pdf

We are yet to scrutinize Sorensen et al's spike positions as they may relate to the RGD sequence of SL-CoVZC45, above.

 

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As the Sortensen report above seems to have been scrubbed, it is time to scrutinize its history, including rejection by Nature:

The Fight for a Controversial Article
(If USMB software tweaks over these URLs, the pages can be retrieved on the net.)

The fight for a controversial article

Birger Sørensen and Angus Dalgleish failed to get an article about the origins of the coronavirus published in a scientific journal. The authors suspect foul play and political considerations. Not everything gets published, is the answer from the journals. Minerva has obtained a draft of the...

www.minervanett.no

We'll try this URL just as it appears when one finds it on the net:

The Evidence Which Suggests That This Is No Naturally Evolved Virus
minervanett.no/angus-dalgleish-birger-sorensen-coronavirus/the-evidence-which-suggests-that-this-is-no-naturally-evolved-virus/362529

 

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The evidence which suggests that this is no naturally evolved virus

Minerva has uploaded a version of the controversial article that claims the coronavirus is not natural in origin.

www.minervanett.no

 

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We've already established the RGD motif sequences that link Duchenne muscular dystrophy to the SARS-like virus ZC45 from Rhinolophus pussilus. In the Sorensen et al, report, they question the origin of the Calu-3 cells (lung cancer) that Baric was using to grow the Yunnan virus, RsSH014, from Rhinolophus sinicus, collected in Yunnan in 2011. Here we link cancer to Duchenne muscular dystrophy and the golden retrievers being kept at Chapel Hill, mentioned previously:

2021 Italy / Duchenne and Cancer

Have Duchenne Muscular Dystrophy Patients an Increased Cancer Risk? - PubMed

Prevalence of cancer in general in the Italian DMD patients does not seem to be different from that in the general population with the same age range. Although the small numbers herein presented do not allow definitive conclusion, the frequent occurrence of RMS in DMD patients raises an alert...

pubmed.ncbi.nlm.nih.gov

'....Although the small numbers herein presented do not allow definitive conclusion, the frequent occurrence of rhabdomyosarcoma in Duchenne muscular dystrophy raised an alert for basic researchers and clinicians.'

Since wild boars from pre-Nazi Germany were introduced into North Carolina in 1913, porcine viruses such as PRRSV (a related Nidovirus like coronavirus), link PRRSV outbreak in Indiana, for example, to this following report.

For further details, the reader will hit a $51 paywall:
Aug 2019 Tick-Borne Kyasanur Virus / Rhabdomyosarcoma / Porcine Stable Kidney Cells / Pipistrellus ceylonicus Bat Embryo Cell Lines

Growth Kinetics of Kyasanur Forest Disease Virus in Mammalian Cell Lines and Development of Plaque Reduction Neutralization Test - PubMed

Kyasanur forest disease virus (KFDV) is a tick-borne flavivirus identified in 1957 in the Karnataka state of India causing fatalities in monkeys and humans. Even after the introduction of a vaccine in the endemic areas, hundreds of cases are reported every year. Being a high-risk category...

pubmed.ncbi.nlm.nih.gov

 

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This is the updated version of the Huanan Seafood Market outbreak:

9 Oct 2022 Zoonosis at the Huanan Seafood Market: A Critique

Zoonosis at the Huanan Seafood Market: A Critique

Here we review data supporting a zoonosis hypothesis at the Huanan Seafood Market (HSM). We undertake statistical analysis of case locations and wildlife stall locations. We additionally analyze environmental sampling and review the likelyhood of susceptible animals carrying a SARS-CoV-2...

zenodo.org

'....Four of the earliest identifiable cases with onset in Dec (10th-16th) were not linked to the HSM, clearly indicating human-to-human transmission outside the HSM prior to and simultaneously with, the first known case as the HSM.'

 

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Edward Hooper (aidsorigins.org) seems to have dropped out of the C19 origins debate, though he is certainly acquainted with Worobey and Edward C. Holmes.

17 hr ago A New Critique of Worobey
10 Oct 2022

The geospatial data of Worobey et al. statistically links the Wuhan Institute of Virology with the Huanan Seafood Wholesale Market

The geospatial statistical analysis of the earliest COVID-19 cases in Wuhan recently given by Worobey et al. (published in Science on 26 July 2022) is selective

papers.ssrn.com

'....Our results cast doubt on a primary point of evidence in favor of a natural origin hypothesis.'

10 Oct 2022
biorxiv.org/content/10.1101/2022.10.10.511625v1
'....The paper's methods do not justify their conclusions, and the origin of SARS-CoV-2 remains an urgent, open question for science.'

 

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Statistical challenges for inferring multiple SARS-CoV-2 spillovers with early outbreak phylodynamics

Understanding how SARS-CoV-2 entered the human population, thereby causing the COVID-19 pandemic, is one of the most urgent questions in science today. Two hypotheses are widely acknowledged as being most likely to explain the pandemic’s origin in late 2019: (i) the “natural origin” hypothesis...

biorxiv.org

 

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Climate science is also here. Five recent publications challenge the natural origins hypothesis:

https://twitter.com/pathogenetics

 

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We now link bungarotoxin (post # 1228) to Wuhan:

Sep 2022 Fatal Snake Bite

Forensic identification of a fatal snakebite from Bungarus multicinctus (Chinese krait) by pathological and toxicological findings: a case report - PubMed

Bungarus multicinctus (B. multicinctus) is one of the top ten venomous snakes in China, ranking first in lethality at 26.9-33.3%. However, to our knowledge, no forensic autopsy-related cases of death from B. multicinctus bite poisoning have been reported. There are surprisingly few reported...

pubmed.ncbi.nlm.nih.gov

'....Department of Forensic Medicine, Tongji Medical College, Wuhan, PRC....ranking first in lethality....female, Fujian Province.'

If Bungarus neurotoxin ranks first in lethality in China, it's not surprising that Ft. Detrick would study its venom in 1988, though the potency increase by chloroquine is also intriguing.

 

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Ebright: 80% Kill Rate / Omicron Cross

https://twitter.com/R_H_Ebright

Omicron-based vaccine came in August for children 5-11 years of age. We posted on the mouse origins of Omicron on 26 Jan 2022, post#6:

Omicron subvariant BA.2 raises new questions about puzzling evolution of virus behind COVID-19

All one can do is read and educate oneself. Will our leaders do the important and necessary work for us? https://www.cbc.ca/news/health/omicron-subvariant-ba-2-raises-new-questions-about-puzzling-evolution-of-virus-behind-covid-19-1.6327270 Unlocking the mysteries behind Omicron's unique set...

www.usmessageboard.com

 

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No other media except USMB seems to have mentioned the N969K Omicron mutation linking to vaccine.

30 Nov 2021 Post #4

Top 5 states for new Covid infections ALL Blue states. Bottom 5 mostly Red.

I guess all that talk about Trump states spreading the virus is a myth. Top 5 states with most daily COVID cases are now blue states, bottom 5 are mostly red As the U.S. braces for the new variant, states with the highest daily rate of news cases are predominantly led by Democrats who have...

www.usmessageboard.com

 

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The Boston report with Ukraine map:

17 Oct 2022 Sputnik News

https://sputniknews.com/20221017/just-why-boston-university-researchers-combine-omicron-wuhan-strains-to-make-deadliest-covid-ever-1101966140

The Wuhan strain does not carry the N969K mutation, the Omicron strain does. Big Pharma, having created the Omicron vaccine for kids, never made a peep about the N969K mutation in the heptad repeat region of the spike. We see mutations to lysine (K) also in alpha-neurotoxins of cobra and krait.

Therefore, to be scientific, the Boston University report should mention either the absence or presence of N969K in their deadlier new virus.