No effect since I only drink coffee up to mid day or so.
Currently most healthcare professionals agree that coffee, at least in reasonable amounts, can:
Boost energy
May lower risk of type 2 diabetes
Could support brain health
May promote weight management
Linked to lower rate of depression
Could protect against some liver disease
Supports heart health
Could increase longevity
Might increase athletic performance (and by default your sex life

Studies suggests may lower risk of breast cancer
etc.
Coffee is a major source of antioxidants. It's health benefits may include improved brain function and a lower risk of several diseases.
www.healthline.com
Coffee has different effects on breast cancer for different women. Coffee can increase tamoxifen and reduce chemo treatment effects.
foodforbreastcancer.com
Of course too much coffee has its definite downsides so, as in most things, moderation is the key.
I generally have no more than one to three cups a day. I enjoy it and do believe I feel better when I drink it.