Yes, much more enzyme study seems required. The Tennessee-Korean report mentions the balance between collagenase and its inhibitor. We think that this iranian report will mesh nicely for insight into the modus operandi of basal cell carcinoma:
Iran / Marine/Human Fibroblast Collagenase
Molecular Dynamics and Docking Investigations of Several Zoanthamine-Type Marine Alkaloids as Matrix Metaloproteinase-1 Inhibitors. - PubMed - NCBI
'....enol-iminium form more inhibitory than the keto form....'
The epidermal tissues of Zoanthus are on the cutting edge of anti-basal cell carcinoma chemistry.
Zoanthus locations are southern Japan and Brazil.
Increased Resistance to UV Light
Distribution and possible function of the marine alkaloid, norzoanthamine, in the zoanthid Zoanthus sp. using MALDI imaging mass spectrometry. - PubMed - NCBI
-- The lack of a calcium carbonate skeleton meshes evolutionarily with the uveal melanoma connection to the eyes of trilobites, which are optically pure calcium carbonate. Thus NMSC (non-melanoma skin cancer) differs exemplary in Zoanthus.
-- It is found on reef flats exposed to high intensity light and intermittent strong currents.
-- It synchronizes the release of gametes with extremely low tides, which will link to circadian rhythym genes in the fish models of melanoma, such as clock, sgk2, ppargc1a, atm, etc.
-- Both intra- and extracellular methods of digestion, linking the balancing chemistry (collagenase and its inhibitor) to human BCC.
