pain management

[gubby18]

why have most of the big chain pharmacys in Sarasota Fl. stopped selling roxicodone.I have been using it for stynosis in my back and also in my neck.ALL of a sudden i cant find it anywhere.Is it the govener or the DEA. Please help.

 

[waltky]

Makin' pain meds harder to abuse...

FDA Seeking Hard-to-Abuse Painkillers
January 11, 2013 - Is there a good way to make prescription painkillers more difficult to abuse? The Food and Drug Administration says the science of "abuse-deterrence" is relatively new, and it is encouraging additional scientific and clinical research to advance the development of drugs that are difficult to abuse.

It's also considering how to evaluate such studies, as well as what claims to eventually allow on drug labels. In the meantime, the FDA said it will take a "flexibile" approach to the evaluation and labeling of potentially abuse-deterrent drugs. Prescription opioid analgesics -- painkillers such as oxycodone -- are an important component of modern pain management, the FDA says in a recently released "guidance" for the industry." It also notes that abuse and misuse of pain-killers has created a serious and growing public health problem.

The FDA wants to make pain-killers available to those who need them, and therefore it considers the development of abuse-resistant drugs to be a "high public health priority." Current abuse-deterrent formulations are intended to prevent people from abusing pain medications, either by swallowing them whole, crushing and swallowing, crushing and snorting, crushing and smoking, or crushing, dissolving and injecting.

Abuse-deterrents generally fall into the following categories:

-- Physical/Chemical barriers can change the physical form of an oral drug, making it less easy to abuse by chewing, crushing, cutting, grating or grinding.

-- Agonist/Antagonist combinations can be added to a drug to reduce or defeat the euphoria associated with abuse. Some "antogonists" would be released only if the drug is improperly chewed, injected or otherwise manipulated.

-- Aversion: Substances can be combined to produce an unpleasant effect if too much medication is ingested or injected.

-- Delivery system: Certain drug release designs or the method of drug delivery can offer resistance to abuse. Shots and implants, for example, can be more difficult to manipulate.

-- Some drugs can be delivered in inactive form, transformed only when they reach the gastrointestinal tract.

The FDA says two or more of the above methods can be combined to deter abuse. The FDA guidance says studies designed to evaluate the abuse-deterrent characteristics of pain-killers should be "scientifically rigorous," and take into consideration the most common way the drug is abused.

FDA Seeking Hard-to-Abuse Painkillers | CNS News

 

[waltky]

To Fix That Pain In Your Back, You Might Have To Change The Way You Sit...

To Fix That Pain In Your Back, You Might Have To Change The Way You Sit
August 13, 2018 - My back hurts when I sit down.

It's been going on for 10 years. It really doesn't matter where I am — at work, at a restaurant, even on our couch at home. My lower back screams, "Stop sitting!" To try to reduce the pain, I bought a kneeling chair at work. Then I got a standing desk. Then I went back to a regular chair because standing became painful. I've seen physical therapists, orthopedic surgeons and pain specialists. I've mastered Pilates, increased flexibility and strengthened muscles. At one point, my abs were so strong my husband nicknamed them "the plate." All these treatments helped a bit, at first. But the pain never really went away. So a few years ago, I decided to accept reality: Sitting down is — and will always be — painful for me.

Then back in November, I walked into the studio of Jenn Sherer in Palo Alto, Calif. She is part of a growing movement on the West Coast to teach people to move and sit and stand as they did in the past — and as they still do in other parts of the world. For the past 8 years, Sherer has been helping people reduce their back pain. I was interviewing Sherer for a story about bending. But she could tell I was in pain. So I told her my story. Her response left me speechless: "Sitting is a place where you can find heaven in your joints and in your back," she says. "It's not sitting that's causing the pain, it's how you're sitting. "Do you want me to show you how?"

Do hunter-gatherers sit less than we do?

Recently there's been a lot of talk about how much Americans sit. There's a perception that we sit way more than any other culture out there — or even any culture throughout time. For the first time in human history, we sit for these long stretches, day after day. Anthropologist David Raichlen at the University of Arizona says that is not accurate. "No. Not from our data," says Raichlen. Raichlen studies modern hunter-gatherers called Hadza, in Tanzania. They live primarily off wild foods, such as tubers, honey and barbecued porcupines. And to acquire this food, there's no doubt they are active. They climb and chop trees to get honey. They dig for tubers and pound nuts. "They do a lot of upper body work," Raichlen says. "And they spend quite a bit of time walking — at a pretty high rate of speed."

On average, Hadza adults spend about 75 minutes each day exercising, Raichlen says. That amount is way more than most Americans exercise. Many of us can't muster a measly 2.5 hours each week, as recommended by the Centers for Disease Control and Prevention. So there's no doubt the Hadza are in better cardiovascular health than most Americans. But do the Hadza actually sit less than we do? A few years ago, Raichlen and colleagues decided to find out. They strapped heart-rate monitors onto nearly 50 Hadza adults for eight weeks and measured how often each day, they were just, well ... sitting around. The results shocked Raichlen. "The Hadza are in resting postures about as much as we Americans are," he says. "It's about 10 hours a day."


By comparison, Americans sit about nine to 13 hours each day, on average, a study reported in 2016. But here's the thing: The Hadza don't seem to have the back issues that we Americans have, even as they age. "Not that we have found," Raichlen says. "There hasn't been a ton of studies looking into muscle and joint pain in the Hadza groups, but people are highly active across the life span. There are some declines in activity with age but nowhere near what you get in the U.S."


Not how much, but how we sit