I have my personal favorite. Before I retired, I met a researcher at the NIH who did an elegantly simple experiment that, at that time, was startling. I had an appointment to meet with her and she kept excusing herself for phone calls. I asked her if it was a bad time, that I could reschedule. She said no, she just had to do some brief interviews. I asked her if she was hiring new staff and she said no, it was interviews with the press.
She said she was getting calls from all over the world following news releases from her institute and the NIH. This is what she did.
She took brain tissue from 10 women at autopsy who had died from leukemia. The brains, other than having been subjected to chemotherapeutic agents, and bone marrow transplant protocols, were otherwise normal. She used molecular biology techniques to investigate those tissues with a Y chromosome specific probe.
In every single woman who had received a bone marrow donation from a male, they had functioning neurons with Y chromosomes. This showed two things which were big news at that time.
1. There were cells present in normal adult blood that could differentiate into something as sophisticated as a functioning neuron.
2. The human brain is adding new neurons even as an adult.
Cool stuff.
Discover always comes up with interesting articles. I’m sure there are others, but these 10 seem to top any list.
3rd Century BC – Eratosthenes measures the world.
1628 – William Harvey discovers blood circulation
1855-1863 – Gregor Mendel experiments with the fundamental rules of genetic inheritance
1665-1666- Isaac Newton on the nature of colors and light (thought it was going to be the apple thing?)
1887 – Michelson and Morley Whiff on the way light moves
1898 – Marie Curie defines radioactivity
1890s – 1900s – Ivan Paval on the discovery of conditioned reflexes
1909 – Robert Milikan determines the precise value of a single electron’s charge
1801 and 1927, respectively - Young, Davisson and Germer on the wavelike nature of light and electrons
1966 – Robert Paine on the disproportionate impact of keystone species on ecosystems
The details of each @
The Top 10 Science Experiments of All Time | DiscoverMagazine.com