Mere chemistry does not produce life; only complex structures produce life.
. . . The self-ordering chemical properties of nature are monomeric dead ends. Nature can form some amino acids and nucleobases; it can form some biotic phosphates as well as some abiotic sugars and fatty acids in calcified forms. Where does it ever form proteins or nucleosides (let alone nucleotides) outside living cells? And beyond living cells and the in vitro experiments conducted under laboratory conditions, where does nature ever polymerize and replicate complex compounds?
. . . A nucleoside is formed when a ribose sugar is added to a nitrogenous base (nucleobase). While the purine nucleosides adenosine and guanosine can be synthesized by adding a ribose, the reaction will not occur in water. But, of course, this reaction is performed in laboratories by biochemists using ribose sugars derived from extant organisms. In the prebiotic world, the reaction would not have occurred in dry environments either. But even if ribose had been available to the primordial soup, the phosphate in biological systems is an ester of phosphoric acid, not a salt. It could have only maintained its composition in deep waters, where ribose can't go, beyond the reach of ultraviolet light. The pyrimidine nucleosides uridine, cytidine and thymidine require both ribose and phosphate to form. Ribose sugars will not bond to the pyrimidine bases without phosphate. Hence, the maturation of the pyrimidines proceeds from nucleobase to nucleotide in one step.
But even if nature could manage the synthesis of nucleotides, their mixtures would invariably be racemic. Worthless. They'd have to be purified, and after that, concentrated and activated before the polymerization phase could begin. And a template? (Whose got the friggin' template?) Well, polymerization would just have to start without one. Besides, the forces of molecular chemistry would supposedly sort things out: even if pyrimidines won't polymerize without a template and even if the significance of organic information doesn't reside in the nucleobase "letters" or even in the condon "words", but in their sequence. All of these things and more would have to occurfrom molecule to compound, from aggregation to polymerization, from replication to recombination, from transmutation to realizationin a contaminate-invested environment incessantly pushing the process in the wrong direction. M.D. Rawlings