I have other pistols available, but 90% of the time I choose a 22lr 9 shot revolver.
I know, it's not sexy, and it won't take down a water buffalo, but I can make a pretty good case for my choice.
1) I practice with it...a lot. Ammunition is cheap and I have plenty of it and it's fun. This is key.
2) Reduced likelihood of over penetration...I live in town, I don't want to shoot my own family or the neighbors with rounds that easily penetrate walls. Chance are very good that no 22LR bullets will leave the house.
3) Time on target...With a 22LR, the limited recoil allows multiple on target shots in minimum time.
You gotta go with what you can afford. I bought a basket case H&R 9-22 for $35 literally in a cigar box in pieces that someone had taken apart. I could see immediately that the important stuff was there, Frame/barrel, cylinder, hammer and grips. All it needed was the plate the mainspring rests on and I made one. It's in my toolbox in the workshop for protection against rabid things. It shoots good and intimidates coyotes when they come howling around. They say a .38 special is underpowered but i'd rather have it than a puny .22 against two legged coyotes.
The graph is pretty clear on this: .22 caliber firearms are just as deadly in a gunfight as any other handgun caliber. In fact, it beat the average (far right). Surprisingly, every caliber that begins with a 4 (.40 S&W, .45, .44 Mag ) performed worse than the .22 caliber firearms in terms of putting the opponent in the dirt for good.
Ask Foghorn: Is .22lr The Best for Self Defense? | The Truth About GunsThe Truth About Guns
Thats pretty interesting. Could it be that more people have shotguns and .22s ?
Or did they take an equal sampling of all categories?
The shotgun doesnt surprise me. But the .22 most definitely does. Which makes me think the chart shows a lot of people own .22s. And of course shotguns.