excalibur
Diamond Member
- Mar 19, 2015
- 22,765
- 44,343
- 2,290
From a pre-print in The Lancet.
I never trusted the mRNA shots and would never take one. ANd have recommended that anyone who must have a Covid vaccine take the J&J.
This preprint research paper has not been peer reviewed. Electronic copy available at: Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?
I never trusted the mRNA shots and would never take one. ANd have recommended that anyone who must have a Covid vaccine take the J&J.
...
CONCLUSIONS
Potential differences in the effects of adenovirus-vector and mRNA vaccines on overall mortality if true, could have a major impact on global health. If validated in additional studies, the protective heterologous effects of adenovirus-based vaccines on non-COVID-19 mortality, in addition to their effectiveness against SARS-CoV-2 infection, may represent an important advantage in vulnerable populations in which cardiovascular mortality is important. The differences in heterologous effects between various vaccine types need to be explored and, if confirmed, taken into consideration when planning future public health policy.
Ironically, the rich countries in Europe and USA have emphasized the more expensive mRNA vaccines because these vaccines have slightly better short-term vaccine efficacy against COVID-19 than the relatively inexpensive adenovirus-vector vaccines, and due to the detection of a rare blood clotting disorder associated with the adenovirus-vector vaccines. While this decision is understandable in the short-term during a situation with high COVID-19-related mortality, in the endemic situation in which COVID-19-related deaths have decreased this decision may need to be reassessed. Otherwise, if the protective effects of adenovirus-vector vaccines on overall mortality in the RCTs reflect the reality, this could turn out to be a very costly decision, both economically and health wise.
Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?
To examine the possible non-specific effects (NSEs) of the novel COVID-19 vaccines, we reviewed the randomised control trials (RCTs) of mRNA and adenovirus-vect
deliverypdf.ssrn.com
This preprint research paper has not been peer reviewed. Electronic copy available at: Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?