Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?

excalibur

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Mar 19, 2015
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From a pre-print in The Lancet.

I never trusted the mRNA shots and would never take one. ANd have recommended that anyone who must have a Covid vaccine take the J&J.


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CONCLUSIONS
Potential differences in the effects of adenovirus-vector and mRNA vaccines on overall mortality if true, could have a major impact on global health. If validated in additional studies, the protective heterologous effects of adenovirus-based vaccines on non-COVID-19 mortality, in addition to their effectiveness against SARS-CoV-2 infection, may represent an important advantage in vulnerable populations in which cardiovascular mortality is important. The differences in heterologous effects between various vaccine types need to be explored and, if confirmed, taken into consideration when planning future public health policy.
Ironically, the rich countries in Europe and USA have emphasized the more expensive mRNA vaccines because these vaccines have slightly better short-term vaccine efficacy against COVID-19 than the relatively inexpensive adenovirus-vector vaccines, and due to the detection of a rare blood clotting disorder associated with the adenovirus-vector vaccines. While this decision is understandable in the short-term during a situation with high COVID-19-related mortality, in the endemic situation in which COVID-19-related deaths have decreased this decision may need to be reassessed. Otherwise, if the protective effects of adenovirus-vector vaccines on overall mortality in the RCTs reflect the reality, this could turn out to be a very costly decision, both economically and health wise.


This preprint research paper has not been peer reviewed. Electronic copy available at: Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?
 

Highlights​



mRNA vaccines promote sustained synthesis of the SARS-CoV-2 spike protein.

The spike protein is neurotoxic, and it impairs DNA repair mechanisms.

Suppression of type I interferon responses results in impaired innate immunity.

The mRNA vaccines potentially cause increased risk to infectious diseases and cancer.

Codon optimization results in G-rich mRNA that has unpredictable complex effects.

Abstract​

The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.








Might as well add to your fact supply, Man if only ppl would pay attention even doctors are waking up
to this lie a lot are coming forward…
 

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