Pregnenolone Can Protect the Brain from Cannabis Intoxication

NumburrOne

Member
Joined
Dec 31, 2013
Messages
116
Reaction score
9
Points
16
Abstract
Editor's Summary



Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.

Pregnenolone Can Protect the Brain from Cannabis Intoxication
 

Vox

Gold Member
Joined
Jun 17, 2013
Messages
10,937
Reaction score
867
Points
138
OK, so what's the point of smoking a joint if you are not getting high?
 
OP
NumburrOne

NumburrOne

Member
Joined
Dec 31, 2013
Messages
116
Reaction score
9
Points
16
OK, so what's the point of smoking a joint if you are not getting high?
not a damn thing...
I see in the future this hormone getting cooked down into a glycerin mixture that is sprayed to eliminate the high...
That eliminates the weed need...
Damn Baptist scientist....
:lol:
 
OP
NumburrOne

NumburrOne

Member
Joined
Dec 31, 2013
Messages
116
Reaction score
9
Points
16
bump for all the legalization fanatics...
one step away from taking the fuzz out of your buzzzzzzz....
 
OP
NumburrOne

NumburrOne

Member
Joined
Dec 31, 2013
Messages
116
Reaction score
9
Points
16
Why would you want to do that?
I don't, just informing you of the latest medical trials to find an inhibitor, this is also good for children using it for epilepsy or other medical conditions, they will still get the benefits they need without the high, kinda like near beer...
 

Most reactions - Past 7 days

Forum List

Top