Pregnenolone Can Protect the Brain from Cannabis Intoxication

[NumburrOne]

Abstract
Editor's Summary



Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.

Pregnenolone Can Protect the Brain from Cannabis Intoxication

 

[Vox]

OK, so what's the point of smoking a joint if you are not getting high?

 

[NumburrOne]

OK, so what's the point of smoking a joint if you are not getting high?

not a damn thing...
I see in the future this hormone getting cooked down into a glycerin mixture that is sprayed to eliminate the high...
That eliminates the weed need...
Damn Baptist scientist....

 

[NumburrOne]

bump for all the legalization fanatics...
one step away from taking the fuzz out of your buzzzzzzz....

 

[CrusaderFrank]

Why would you want to do that?

 

[NumburrOne]

Why would you want to do that?

I don't, just informing you of the latest medical trials to find an inhibitor, this is also good for children using it for epilepsy or other medical conditions, they will still get the benefits they need without the high, kinda like near beer...

 

[g5000]

Why would you want to do that?

For the treatment of addiction. Like Antabuse for alcohol addiction.