Cogent..if a bit high-brow for some.There is a nice representation of what happens when ivermectin docks to SARS-CoV-2 RBD-ACE2 complex, Fig. 3, here:
Ivermectin Docks to the SARS-CoV-2 Spike Receptor Binding Domain Attached to ACE2
’Fig. 3. Ivermectin molecule docked with SARS-CoV-2 spike....Vero-hSLAM cell assays used by Caly et al might not be entirely relevant to human SARS-CoV-2 infection. Vero-hSLAM is an African green monkey kidney epithelial cell line that does not express human ACE2. Therefore, Caly et al had to use high concentrations.’![]()
Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2 - PubMed
The ivermectin docking we identified may interfere with the attachment of the spike to the human cell membrane. Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection.pubmed.ncbi.nlm.nih.gov
Thus...high doses (concentration) were used..the binding was observed..but the relevance, if any, is not known, at this time. Given that the subject was a Green Monkey--a kidney cell----that would go without saying, eh?
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