’Many more children’ so we take a closer look at severity biomarkers and clues to long COVID, linking another nidovirus, lactate-dehydrogenase-elevating virus (LDV):
From Flutrackers this recent post:
24 Aug 2021 Japan: Biomarkers of Severity
The evaluation of severity is valuable, as the mortality rate was high in the moderate II and severe stages. The levels of CRP, ferritin, PCT, albumin, and LDH were useful markers of severity, and hemostatic abnormalities were frequently observed in patients in the severe disease stage.
pubmed.ncbi.nlm.nih.gov
’....The change in AST (aspartate aminotransferase) was small and levels fell to within the normal range in patients with moderate II disease....
LDH levels have been reported associated with Acute Physiological and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA), and computed tomography (CT) semiquantitative rating scores, and LDH is suggested to be a useful marker for multiple organ failure.
....
Limitations associated with this present study was that it was observational, and thus affected by comorbidities and varying therapies.’
AST Levels in Children / Liver Fat Fraction
Our results indicate a strong correlation between LFF values and AST and ALT levels in children who are overweight and obese.
pubmed.ncbi.nlm.nih.gov
’....in overweight and obese groups, the liver proton density fat fraction and AST levels had a strong correlation.’
Lactate dehydrogenase-elevating virus (LDV) originally from a European mouse, links to the evolution of what may be SARS-CoV-2’s most ancient ancestor, PRRSV, a pig coronavirus. Therefore, suspect is the introduction of wild boars from Germany into North Carolina in 1913.