Hydroxychloroquine cuts Covid-19 death rate by 50%

[Erinwltr]

A new study indicates hydroxychloroquine may reduce the Covid-19 death rate by 50%:

Hydroxychloroquine can help save hospitalized coronavirus patients, study finds

A team at Henry Ford Health System in Southeast Michigan said Thursday that a study of 2,541 hospitalized patients found that those given the drug were far less likely to die, CNN reported.

nypost.com

As a result, the FDA may reverse its disapproval of this drug. The question remains whether it will cause serious psychological side effects in those patients already suffering from TDS.

"Researchers not involved in the new research said it wasn’t as sound as others studies showing hydroxychloroquine did not help patients, and said other treatments, such as the use of the steroid dexamethasone, might have accounted for the better survival rate, according to CNN."

 

[Jitss617]

Wow you just triggered a hoard of trolls lol

 

[WEATHER53]

Governor of NJis biggest idiot of the bunch. He has his very own special calculation for”rrate” of infection and it’s now at 1.03 and his maximum allowedi is 1.0 so game over for summer.

 

[badger2]

Part of the confusion is epressed in these studies:

Dexamethasone Steroid Resistance/ Sensitivity

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target - PubMed

Steroid refractory inflammation is an unmet medical need in the management of inflammatory diseases. Thus, mechanisms, improving steroid sensitivity and simultaneously decreasing inflammation have potential therapeutic utility. The FK506-binding protein 51 (FKBP51) is reported to influence...

www.ncbi.nlm.nih.gov

Steroid-Sparing Hydroxychloroquine / Steroid Resistance

Hydroxychloroquine is a safe and effective steroid-sparing agent for immune checkpoint inhibitor-induced inflammatory arthritis - PubMed

Immunotherapy for cancer treatment continues to evolve, and immune checkpoints have proven successful therapeutic targets. With success has come the challenge of managing the commonly associated immune-related toxicities. Arthralgias and arthritis are a common immune-related adverse event...

www.ncbi.nlm.nih.gov

Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria - PubMed

Hydroxychloroquine as a steroid-sparing agent in an infant with chronic urticaria

www.ncbi.nlm.nih.gov

 

[badger2]

COVID-19 autopsies show rare megakaryocyte involvement, and thrombopoietin receptors are on the surface of megakaryocytes, which latter link dengue virus infection.

SLE / Hydroxychloroquine / Megakaryocytes

Eltrombopag as steroid sparing therapy for immune thrombocytopenic purpura in systemic lupus erythematosus - PubMed

Eltrombopag is effective as a rapidly acting corticosteroid sparing therapy for patients with ITP associated with SLE. This is important in reducing corticosteroid related side effects and morbidities in treating SLE patients with ITP. Larger studies are needed to ascertain safety and efficacy...

www.ncbi.nlm.nih.gov

'megakaryocytes....some immunomodulatory agents (e.g. hydroxychloroquine) were continued to control non hematologic SLE manifestations.'

 

[badger2]

We next link Wuhan to the NF-kappaB shown for FKBP51/dexamethasone (post #44):

Jan 2020 Wuhan Agricultural University / Coronavirus / NF-kappaB

Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets - PubMed

Porcine deltacoronavirus (PDCoV) is a porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and frequently death in piglets, causing serious economic losses to the pig industry. The strain CHN-JS-2017 was isolated and identified by cytopathology, immunofluorescence assays...

www.ncbi.nlm.nih.gov

 

[badger2]

Note that now we can show an interesting gender factor, because the Wuhan report (post #46) states, '....CHN-JS-2017 infected five-day-old piglets could significantly downregulate the expression of FcRN, pIgR, and nuclear factor kappa-B in the intestinal mucosa.'

pIgR is the polymeric immunoglobulin receptor.

'Estradiol has been shown to upregulate pIgR expression in human endometrium and endometrial cell lines (Menge-Westecky, Surface Expression of Secretory Component of HLA class II DR Antigen on Glandular Epithelial Cell Lines from Human Endometrium and Two Endometrial Adenocarcinoma Cell Lines, J. Clin. Immunol. 13:259) and in rat uterus pIgR expression is upregulated by estrogen and antagonized by progesterone. By contrast, pIgR in rabbit mammary is upregulated by prolactin and antagonized by estrogen and progesterone. In the male reproductive tract, including prostate and seminal vesicles, pIgR is increased by androgens (Secretory Immune System of the Male Reproductive Tract: Effects of Dihydrotestosterone and Estradiol of IgA and Secretory Component Levels, J. Reproductive Immunol. (1992) 22:77). Interestingly, androgens also upregulate pIgR expression in the lacrimal gland of male rats in which SC (secretory component) output in tears is 5-fold higher than in female rats (Sullivan et al [1984] Hormonal Influence on the Secretory Immune System of the Eye: Androgen Regulation of Secretory Component Level in Rat Tears, J. Immunol. 132: 1130).'
(Mucosal Immunity, p. 191)

ACE2 receptors in human conjunctiva as potential entry point for COVID-19.

 

[badger2]

We began a Pubmed search, which only retrieved one reference, as such: 'COVID-19 polymeric immunoglobulin receptor.' But the Jan 2020 Wuhan report is for virus CHN-JS-2017.

 

[WEATHER53]

Note that now we can show an interesting gender factor, because the Wuhan report (post #46) states, '....CHN-JS-2017 infected five-day-old piglets could significantly downregulate the expression of FcRN, pIgR, and nuclear factor kappa-B in the intestinal mucosa.'

pIgR is the polymeric immunoglobulin receptor.

'Estradiol has been shown to upregulate pIgR expression in human endometrium and endometrial cell lines (Menge-Westecky, Surface Expression of Secretory Component of HLA class II DR Antigen on Glandular Epithelial Cell Lines from Human Endometrium and Two Endometrial Adenocarcinoma Cell Lines, J. Clin. Immunol. 13:259) and in rat uterus pIgR expression is upregulated by estrogen and antagonized by progesterone. By contrast, pIgR in rabbit mammary is upregulated by prolactin and antagonized by estrogen and progesterone. In the male reproductive tract, including prostate and seminal vesicles, pIgR is increased by androgens (Secretory Immune System of the Male Reproductive Tract: Effects of Dihydrotestosterone and Estradiol of IgA and Secretory Component Levels, J. Reproductive Immunol. (1992) 22:77). Interestingly, androgens also upregulate pIgR expression in the lacrimal gland of male rats in which SC (secretory component) output in tears is 5-fold higher than in female rats (Sullivan et al [1984] Hormonal Influence on the Secretory Immune System of the Eye: Androgen Regulation of Secretory Component Level in Rat Tears, J. Immunol. 132: 1130).'
(Mucosal Immunity, p. 191)

ACE2 receptors in human conjunctiva as potential entry point for COVID-19.

You know a lot and thank you. How many other viruses colds and infections do we have that are swarming around us All The Time and if we tested 40 million we would find that lots of people have it but very few critical or deceased and in fact the vast majority don’t know they have it?
Thank you for your reply

 

[badger2]

These scientists we're quoting know a lot: a male link to a pig coronavirus, and the work is from Wuhan. Thus far, anyone with blood-shot eyes (Behcet's disease, drugs, lack of sleep, etc.) or blood-shot conjunctiva could be at added risk for COVID-19 via ACE2 receptors in the eyes.

 

[badger2]

Yes, testing may eventually show more cases that are closer to carrier status (benign, for the most part) than those requiring care.

 

[wamose]

It's amazing how our populist, America first President, knows more about the virus than Fauci and his expert friends. Of course CNN, MSNBC, NYT and WaPo all got it wrong too. Thank God Trump is our President.

 

[badger2]

Pubmed entries for 'hydroxychloroquine' have been scrambled: they are no longer in chronological order so that the most recent studies can be retrieved, as is usually the case at Pubmed.

 

[Polishprince]

A new study indicates hydroxychloroquine may reduce the Covid-19 death rate by 50%:

Hydroxychloroquine can help save hospitalized coronavirus patients, study finds

A team at Henry Ford Health System in Southeast Michigan said Thursday that a study of 2,541 hospitalized patients found that those given the drug were far less likely to die, CNN reported.

nypost.com

As a result, the FDA may reverse its disapproval of this drug. The question remains whether it will cause serious psychological side effects in those patients already suffering from TDS.

I'm not a pharmacologist by any stretch of the word, or an expert in inventing cures and treatments.

However, what amazes me most about Hydroxychloroquine is the joy the libs have shown in rooting for the drug's possible failure. In the past, I think that most people on both sides would be anxious for good treatments and cures for corona.

I don't think that Jonas Salk faced the kind of opposition with fighting polio that Donald Trump has with the Kung Flu. I wonder if Dr. Salk would have been successful if the liberal commentators and politicians of the 50's would have cheered every time he had a set-back?

 

[badger2]

There's a current setback for the covid vaccine, and some companies are turning to treatment instead. We heartily agree with Zelenko's hydroxychloroquine-zinc approach, although mRNA-1273 vaccine could be given more frequently if antibody fade is a problem. Herd immunity should kick in sooner or later, as apparently it has in Sweden.

 

[Zorro!]

Everyone kept expecting the major outbreak in Africa that never came, and nation, that because of Malaria, has Hydroxy available over the counter.

REMIND ME PLEASE WHAT ‘CDC’ STANDS FOR: Is the CDC Downplaying the Efficacy of Hydroxychloroquine To ‘Resist’ Trump?

Health and Human Services Assistant Secretary for Public Affairs Michael Caputo recently warned on Facebook live that the Centers for Disease Control and Prevention (CDC) “was harboring a ‘resistance unit’ to Trump.”

Back in April, it was noted that countries with high rates of malaria have significantly lower COVID-19 mortality rates. Hydroxychloroquine is a decades-old anti-malaria drug.

But CDC’s claim that “current data indicate that the potential benefits of [hydroxychloroquine and chloroquine] do not outweigh their risks” contradicts the plethora of data we have to the contrary.

There have been nearly a hundred studies on the efficacy of hydroxychloroquine, most of them peer-reviewed, which indicate that hydroxychloroquine has a positive impact on mortality, particularly when administered early.

A study published last week out of Saudi Arabia found that “Early intervention with HCQ-based therapy in patients with mild to moderate symptoms at presentation is associated with lower adverse clinical outcomes among COVID-19 patients, including hospital admissions, ICU admission, and/or death.”

Another study published earlier this month of nursing home patients found that patients not treated with hydroxychloroquine found that those receiving standard treatment had a mortality rate more than five times higher than those who were treated with hydroxychloroquine and azithromycin.

In July, a large-scale, peer-reviewed study conducted by the Henry Ford Health System concluded that hydroxychloroquine successfully lowered mortality rates for hospitalized coronavirus patients.

There are currently about a hundred studies on the efficacy of hydroxychloroquine in treating COVID-19 (61 of them peer-reviewed) that overwhelmingly show positive results, particularly when administered early.

Yet, according to the CDC, “the potential benefits of [hydroxychloroquine and chloroquine] do not outweigh their risks.”

Yeah, okay.