Notes on PEDV and Sudden Death
Post #1,651 mentioned the model with epidermolysis bullosa. We add this to the file:
Oct 2016 U. Minn. / EB mir-29 Loss-of-Function Mutation / Col7A1
Recessive dystrophic epidermolysis bullosa (RDEB) is a complex inherited skin disorder caused by loss-of-function mutations in the COL7A1 gene. For an effective treatment of this disorder to be realized, both a thorough understanding of the regulation of COL7A1 and an understanding of the...
pubmed.ncbi.nlm.nih.gov
Because U. Minnesota is also citadel for American pig farming, the trajectory for epidermolysis bullosa mir-29 sets the stage for more on microRNAs. Jikky has recently mentioned them here:
The report mentions such microRNAs as mir-21. So a Pubmed search, 'mir-21 porcine' yields a Chinese military link:
Feb 2021 Fourth Military Medical University, Xi'an / Mir-21
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for treating myocardial infarction have limited success. An effective approach may benefit from resolution of excessive inflammation combined with enhancement of angiogenesis. Here, we developed a...
pubmed.ncbi.nlm.nih.gov
One Twitterist page does mention Fourth Military Medical, and it was seemingly from Xi'an.
So this study from May 2019 shows that uncontrolled microRNA can cause sudden death in pigs:
May 2019 Italy, UK, US / Porcine Sudden Death / MicroRNA
Prompt coronary catheterization and revascularization have markedly improved the outcomes of myocardial infarction, but have also resulted in a growing number of surviving patients with permanent structural damage of the heart, which frequently leads to heart failure. There is an unmet clinical...
pubmed.ncbi.nlm.nih.gov
'....However, subsequent persistent and uncontrolled expression of the microRNA resulted in sudden arrhythmic death of most of the pigs.'
Seemingly, it was from Chan and Ridley's Viral that the manipulation of PEDV was mentioned, recalling that PEDV is the main coronavirus genome that causes sudden death in the host (pigs).