Cancer Cures

[badger2]

L. neomexicanum likely occurs into the Mohave of California. There should be a Micromonspora association with L. lewisii, which grows on caliche. Antibiotics from that association would be very interesting against breast cancer.

 

[badger2]

Variations of L. lewisii rhizosphere organisms will yield clues to anti-breast cancer activity, because of its broad range:

Linum lewisii
http://swsbm.com/Britton-Brown/Linum_lewisii

 

[badger2]

http://swsbm.com/Britton-Brown/Linum_lewisii.gif

 

[badger2]

There are many references for Linum n Hatwell's Plants Used Against Cancer. An interesting example is here:

'Linum usitatissimum, Bazr ul-kattan (Bezer el-kettan Preparation with honey and violet oil for external tumors; Abu Mansur. Achundow, A.-C. 1893 Die pharmakologischen Grundsaetze (Liber fundamentorum pharmacologiae) des Abu Mansur Muwaffak ibn Ali Harawi. In Historische Studien aus dem Pharmakologischen Institute d Kaiserlichen Universitaet Dorpat, ed. R. Kobert.'
(Hartwell Plants Used Against Cancer)

 

[badger2]

Some excerpts from Hegemauer on the Linaceae reinforce the suspicion that cannabis oil anti-cancer activity may be linked to fatty acids and lipid metabolism, as we have already linked CD36 in this thread:

'Weitaus am eingehendsten bearbeitetwurde das technische wichtige Samenoel (Leinoel) von Linum usitatissimum L. Es stellt wegen seinem hohen Linolensaeuregehalt (40-60%) den Prototypus eines trocknenden Oeles dar.'
(Hegenauer, Chemotaxonomie der Pflanzen)

There are also important ratio charts for c-16-C20 fatty acids. Hegenauer also points out the toxicity of Linum neomexicanum:

'Linum neomexicanum Greene enthaelt einen fuer das Vieh toxischen Stoff, der Linotoxin genannt wurde....ein cyanogenes Glucosid ein Saponin darstellen soll....Smith CR, et al Linustatin and Neolinustatin: Cyanogenic G of Linseed Meal that Protects Animals Against Selenium Toxicity, J. Org. Chem. [1980] 45: 507...Yermanos DH, Variability in Seed Oil Composition of 43 Linum Species, J. American Oil Chemists/ Society [1966] 43: 546.'

And Hegenauer provides another link to the Australian Aboriginal tree, Codonocarpus mentioned in this thread:

'Die Cyanhydrine werden durch die Pflanze vermutlich aus Valin und Isoleucin synthetisierte.'
(Hegenauer, op cit)

The last item is suggestive of nutrition of both healthy and cancerous human tissues, and its signature is reflected in Codonocarpus physiology.

 

[badger2]

We next link Viola to Linum of post #324, as Hegenauer continues in the Linaceae, recalling the Valin-Leucine-Isoleucine assemblage of Codonocarpus:

'Hauptflavonoide sind die C-Glykoflavone Orientin, Isoorientin, Vitexin, Isovitexin, Lucenin-1 und -2 und O-Glykoside dieser C-Glykoflavone.'
(Hegenauer, Linaceae, VIII p. 669)

Viola / Vitexin
Tyrosinase and Cholinesterase Inhibitory Potential and Flavonoid Characterization of Viola odorata L. (Sweet Violet). - PubMed - NCBI

 

[badger2]

Thus, the flax-violet assemblage of Bazr ul-kattan links like compounds from two plants before the technology to identify them! The Viola arvensis link to rapeseed and herbicides prompts further investigation of anti-cancer activity of these plants.

Viola arvensis / Orientin
pubs.acs.org/doi/pdf/10.1021/np9701485

 

[badger2]

www. for "Violarvensin, A New Flavone Di-C-Glycoside from Viola arvensis" Journal of Natural Products (1998} 61: 272.

 

[badger2]

Like orientin, the chemical formula for isoorientin is C21H20O11.

Dec 2016 China: Isoorientin / Pancreatic Cancer Apoptosis
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. - PubMed - NCBI

 

[badger2]

Here we link the chemistry of the flax-violet assemblage, noting that the questions would include docetaxel resistance:

Vicenin-2 / Prostate Cancer
Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. - PubMed - NCBI

'2717. Vicenin-2 6,8-Di-C-glucopyranosylapigenin; Apigenin 6.8-di-C-glucoside C27H30O15 from the wood of Vitex lucens (Verbenaceae), Citrus limon (Rutaceae), Spergularia rubra (Caryophyllaceae), Eupatorium serotinum (Compositae) and Viola tricolor (Violaceae).

2718. Violanthin 6-C-Glucopyranosyl-8-C-rhamnopyranosylapigenin; Apigenin 6-C-glucoside-8-C-rhamnoside C27H30O14 Viola tricolor (Violaceae), Gutierrezia microcephala (Compositae), Eleusine spp. (Gramineae) and Angiopteris evecta (Pteridophyta).

2719. Lucenin-2 6,8-Di-C-glucopyranosylluteolin; Luteolin 6,8-di-C-glucoside C27H30O16 Vitex lucens (Verbenaceae), Tragopogon spp., Carlina corymbosa (Compositae), Linum usitatissimum (Linaexeae) and Hedwigia ciliata (Bryophyta).'
(The Handbook of Natural Flavonoids, Vol. I)

Note that Hedwigia is a moss and that vicenin-2 is linked to deliberate self-medication in chimpanzees. Before we made the chimpanzee connection, we were already applying a tincture of Viola tricolor to the basal cell carcinoma of the face.

 

[badger2]

Utah is getting duped. They will be smoking the medicine up rather than making tinctures or oils that may prevent their cancers due to smoking:

'2690. Orietntin 7-glucoside C27H30O18 Cannabis sativa (Cannabidaceae), Phoenix canariensis (Palmae) and Vellozia spp. (Velloziaceae)

2691. Orientin 2"-O-rhamnoside C27H30O15, Fortunella japnica (Rutaceae), Crataegus spp. (Rosaceae) and Podocarpus totara (Podocarpaceae)

2692. Orientin 7-O-rhamnoside C27H30O15 Linum usitatissimum.'
(Handbook of Natural Flavonoids)

If still alive, there will be application of Crataegus to the scapular melanoma through the fall and winter. It is also a premier heart maintenance medicine.

 

[badger2]

Note that isoorientin from Viola yedoensis complements orientin from flax (Linum):

Isoorientin / Viola yedoensis / Collagenase Inhibition
Collagenase inhibitors from Viola yedoensis. - PubMed - NCBI

Collagenase-collagen ratio is a critical parameter as we apply the Viola tincture to the basal cell carcinoma, which cells manufacture collagenase IV with which to degrade surrounding tissues. We will, however, rely on isoorientin from Crataegus rather than Viola on our experimental anti-cancer trajectory.

 

[RodISHI]

I think when you hit forty Hawthorn Berry (best stuff) should be a daily supplement, earlier than that if one has clogged arteries.

 

[badger2]

A good point. Crataegus and its anthocyanidins affect the extracellular matrix composition, and we think that caffeine at 60 and beyond is contraindicated. Utah will be putting smoke chemicals at the extracellular matirx, when they really should be looking closer at Cannabis oil and smokeless cooking. Since one Crataegus link to Cannabis is isoorientin, we will pursue the trajectory for lipid metabolism, especially the cutting-edge CD36 study already mentioned from Spain, linking to metastasis.

What are the constituents of Cannabis oil? It is the Taxol Problem: how to extract only the active constituent (taxol) from the Yew tree and direct those concentrated molecules to the target. If two are indicated, that's still better than hundreds of other things that (may) get in the way.

 

[badger2]

That's two trees to conserve in the American Middle West. American prisoners no longer have access to any plant heritage regarding Schisandra.

'Schisandra propinqua (Wall) Hook f. et Thoms, inhibition of Lewis lung cancer, brain tumor-22, and solid hepatoma.

Ursolic acid (Taiwan): moderate activity against MCF-7 breast cancer, KB, and Het-8 cells. Found in Prunella vulgaris (Labiatae), Psychotria serpens (Rubiaceae), Hyptis capitata.'
(Anticancer Drugs from Animals and Plants)

 

[badger2]

'Today, the gaze is forensic.'
(Rosi Braidotti, Deleuze and Law: Forensic Futures)

While searching for other isoorientin links to Cannabis, we came across an interesting and timely entry for Poland, which must include at least one species of Plagiomnium:

Poland Medicinal Mosses
Medicinal mosses in pre-Linnaean bryophyte floras of central Europe. An example from the natural history of Poland. - PubMed - NCBI
'....rare or extinct....'

2812. Isoorientin 3'-O-neohesperidoside C33H40O20 from Plagiomnium affine

2813. Isoorientin 3'-O-sophoroside C33H40O21 from Plagiomnium affine.'
(The Handbook of Natural Flavonoids)

P. affine does not occure in the U.S., and constituents from U.S. Plagiomnium are yet to be linked to forms of isoorientin for Cannabis comparison. A handful of Plagiomnium species of interest are

1. Plagiomnium carolinianum Tn, NC, Ga, SC

2. P. drummondi Mn, Mi, Oh, Ne, NY, Pa, WVa, ND, Del, Id

3. P. cuspidatum Wi, Ia, many states

4. P. floridanum La, Fla, Ga

5. P. medium Ia, Wi, etc.

6. P. ciliare Ia, Ill, Oh, Mn, etc.

7. P. ellipticum Mn, Wi.

A similar flavonoid links to the folklore of Kentucky for 'mouse-ear' chickweed against cancerous abscesses, already mentioned in this thread. There are at least two candidates for folkloric 'mouse ear,' one being Stellaria, the other, Cerastium:

2804. Schaftoside 6"-O-glucoside C32H38O19 from Stellaria holostea

2806. Isomollupentin 7,2" di-O-glucoside C32H38O19 from Cerastium arvense.'
(The Handbook of Natural Flavonoids)

 

[badger2]

Caryophylline has been mentioned in this thread, which is a constituent of the chickweeds. Here we link it to Cannabis as well as CD36 on the investigative trajectory for lipid/fatty-acid metabolism in cancer:

Cannabidiol / CD36
Activation of GPR55 Receptors Exacerbates oxLDL-Induced Lipid Accumulation and Inflammatory Responses, while Reducing Cholesterol Efflux from Human... - PubMed - NCBI

Trans-caryophylline / Cannabinoid
Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway. - PubMed - NCBI

 

[badger2]

Here we link cannabidiol from Cannabis to herbicides and viruses:

Cannabidiol / Herbamycin
Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells. - PubMed - NCBI
'....two phenolic hydroxyl groups in the pentylresorcinol moiety of CBD....'

Herbamycin is an herbicide and antiviral against tobacco mosaic virus.

Some constituents of cannabis oil are:

alpha-pinene
beta-myrcene
limonene
trans-alpha-bergamotene
humulene
cis-beta-farnesene
beta-caryophylline
carvone
sabinene
alpha-terpineol
estragol

 

[badger2]

We propose a cancer study installation in the Mohave. Having met Mr. Okura in 2006, Amboy, California, area has some potential for solar-operated aquariums for medaka, zebrafish, sword-tails, etc. The Mexican swordtail's range is close to the Sonoran region. Of the founding families of Amboy, Betty died of cancer, though we do not know at this time what type of cancer it was.

The proposed installation would be quasi-linked to Michael Moore's Southwest School of Botanical Medicine, as well as the eye research and tupaia installation of the University of Alabama at Birmingham. Amboy links to Europe, because tourists from The Netherlands, France, Germany, etc., like to rent motorcycles in New York and ride the nostalgia of Route 66.

Some native California species of Crataegus are also native to Wisconsin, and Crataegus propagation can be thought of as an anti-cancer enterprise. We are yet to hear of Crataegus as medicine for fish.

Crataegus Propagation
Some Thoughts on Difficult to Germinate Seeds

 

[badger2]

Note that Mr. Okura's experience in the chicken business links to chickens in the Crataegus germination article.