[Erica] Nader, 26, of Farmington Hills, Mich., was the first American to travel to Portugal, in March 2003, for experimental sugery for spinal cord injury. She was injured in July 2001 in an auto accident... She was paralyzed from the top of her arms down.
In the procedure...a team of doctors opened Naders spinal cord to clear out any scar tissue.... Then, using a long tube, they took a sample of olfactory mucosal cells from the ridge of her nose.... These cells are among the bodys richest supply of adult stem cells and are capable of becoming any type of cell, depending on where they are implanted. In this case, these adult stem cells were to take on the job of neurons, or nerve cells, once implanted in the spinal cord at the site of an injury. ...
And after three years, magnetic imaging resonance tests show that the cells indeed promote the development of new blood cells and synapses, or connections between nerve cells, says Dr. Carlos Lima, chief of the Lisbon team. ...
Dr. Pratas Vital, one of two neurosurgeons on the team, calls the transplanted cells spinal cord autografts, a term that indicates the cells come from a persons own body, not fetal or embryonic stem cells. ...
[Erica] is much stronger and much more capable of lifting her arms, bending her knees on a slanted exercise board and standing erect. ... Once, she was paralyzed from her biceps down. Now, she can push herself off an exercise ball, do arm lifts and help raise herself off a floor mat. ... In the past six weeks, shes started to walk in leg braces with a walker or on a treadmill.
-Patricia Anstett, Paraplegic improving after stem-cell implant, The Indianapolis Star, January 16, 2005, at
www.indystar.com/articles/5/209449-5235-047.html.
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PharmaFrontiers has an exclusive contract to develop stem cells that are created from monocyte white blood cells taken from adult blood donations....
Stem cell treatment for diabetes and heart failure should be commercially available in five to six years, company CEO Dave McWilliams said. The technology actually allows us to change the cells to stem cells and then change them into any type of cell we want, he said. ...
There is no one in the United States currently working on any treatment studies using embryonic stem cells, McWilliams said.
-Burton Speakman, Woodlands firm develops adult stem cells, The Courier Online (Montgomery County; Houston, TX), December 26, 2004, at
www.zwire.com/site/news.cfm?BRD=1574&dept_id=532218&newsid=13627357&PAG=461&rfi=9.
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[E]vidence from three different labs the University of Minnesota, the Robert Wood Johnson Medical School in New Jersey, and Argonne National Laboratory outside Chicago have found three different ASCs [adult stem cells] that may be completely plastic. ... As the team leader at the Robert Wood Johnson School, Ira Black, told me, In aggregate, our study and various others do support the idea that one [adult stem cell] can give rise to all types of tissue. ...
-Michael Fumento, The Adult Answer, National Review Online, December 20, 2004, at
www.nationalreview.com/comment/fumento200412200902.asp.
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Scientists have transplanted adult stem cells from the bone marrow of rats into the brains of rat embryos and found that thousands of the cells survive into adulthood, raising the possibility that someday developmental abnormalities could be prevented or treated in the womb.
Dr. Ira Black, chairman of the department of neuroscience at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, said the cells took on the properties of brain cells, migrating to specific regions and taking up characteristics of neighboring cells.
Black and his colleagues used a specific type of bone marrow cell called a stromal cell, taken from the leg bones of adult rats. We see this potentially as an appropriate treatment for prenatal disease, mental retardation and congenital conditions, Black said. The hope is that a patients own bone barrow might someday be the source for replacing brain cells lost to illness and brain trauma, experts say, eliminating the need to use human embryonic stem cells.
In a separate study, Dr. Alexander Storch of the University of Ulm, Germany, recently took bone marrow and stromal cells from six healthy people and converted the cells into immature neural stem cells. ... A single cell culture could grow all major brain cell types, said Storch, who used specific growth factors to help them differentiate.
Storch is now transplanting the cells into mice with multiple sclerosis, Parkinsons disease and stroke symptoms. In the stroke study, the labeled adult stromal cells migrated to the area surrounding the stroke damage, he said. They had all of the chemical, electrical and functional properties of brain cells.
-Jamie Talan, Stem cell transplant a success, Newsday, May 12, 2004, at
http://www.mult-sclerosis.org/news/May2004/SuccessfulRatStemCellTransplant.html.
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Cord blood stem cells have the same capacity to cure disease as do embryonic stem cells, as they can become any cell in the body
, said Dr. William Schmidt, Jr., an oncologist with the Charleston Cancer Center in N. Charleston, SC.
The use of umbilical cord blood stem cells in the treatment of disease is one of the most prominent advancements in medicine today. Developments in this field will revolutionize medicine and disease treatment, said Dr. [Roger] Markwald [Professor and Chair of the Department of Cell Biology and Anatomy at the Medical University of South Carolina].
-Press Release, CureSource Issues Statement on Umbilical Cord Blood Stem Cells vs. Embryonic Stem Cells, May 12, 2004, at
http://home.businesswire.com/portal...d=news_view&newsId=20040512005909&newsLang=en.
BioE, a biotechnology company that develops antibody-based technology platforms used in the development of therapeutics and diagnostics, announced
it has isolated and defined a unique population of stem cells
.
During the past year, BioE confirmed the existence of these new multilineage progenitor cells (MLPCs) by demonstrating repeatedly their ability to self-renew, expand exponentially and differentiate into a wide variety of tissue types including bone, nerve and muscle.
The discovery of these MLPCs in umbilical cord blood opens up a huge untapped source of stem cells for potential use in regenerative medicine.
-Press Release, BioE Defines New Population of Multilineage Stem Cells in Umbilical Cord Blood, May 11, 2004, at
http://biz.yahoo.com/bw/040511/115796_1.html.
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California scientists have found that neural stem cells can target and track deadly brain tumor cells.
The discovery by researchers at Cedars-Sinais Maxine Dunitz Neurosurgical Institute in Los Angeles means that neural stem cells may someday be effective delivery systems to transport cancer-killing gene and immune products.
We have previously demonstrated the uncanny ability of neural stem cells to seek out and destroy satellites of tumor cells in the brain, said John S. Yu, senior author of the study and co-director of the Comprehensive Brain Tumor Program a Cedars-Sinai.
With this knowledge, we hope to expedite the translation of this powerful and novel strategy for the clinical benefit of patients with brain tumors.
-Press release, Neural stem cells may help fight cancer, May 5, 2004, at
http://www.nlm.nih.gov/medlineplus/news/fullstory_17570.html.
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Were not trying to change the [adult stem] cells in any way before we put them in the body. These are very early precursor cells. They have the potential to become almost anything, and they adapt quickly once theyre inside, said [Tulane University Center for Gene Therapy research professor Dr. Brian] Butcher. Tests on rats with damaged spines have shown that cell growth occurs in the spine [after adult stem cell injection] and allows the animals to walk again.
Using adult stem cells sidesteps some of the legal and ethical issues involved in using fetal
or embryonic stem cells
. And there may be other benefits as well. Were not against stem-cell research of any kind, said Butcher. But we think there are advantages to using adult stem cells. For example, with embryonic stem cells, a significant number become cancer cells, so the cure could be worse than the disease. And they can be very difficult to grow, while adult stem cells are very easy to grow.
But perhaps the biggest advantage to adult stem cells is that they sidestep immunological concerns because the cells used to treat a patient come from his or her own body.
-Heather Heilman, Great Transformations, The Tulanian, Spring 2004, at
http://www2.tulane.edu/article_news_details.cfm?ArticleID=5155.