Possible additional benefit to daily low-dose aspirin

[Delta4Embassy]

http://medicalxpress.com/news/2015-11-breakdown-product-aspirin-blocks-cell.html

"A new study finds that a component of aspirin binds to an enzyme called GAPDH, which is believed to play a major role in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases.

Researchers at the Boyce Thompson Institute and John Hopkins University discovered that salicylic acid, the primary breakdown product of aspirin, binds to GAPDH, thereby stopping it from moving into a cell's nucleus, where it can trigger the cell's death. The study, which appears in the journal PLOS ONE, also suggests that derivatives of salicylic acid may hold promise for treating multiple neurodegenerative diseases.
...

The anti-Parkinson's drug deprenyl blocks GAPDH's entry into the nucleus and the resulting cell death. The researchers discovered that salicylic acid also is effective at stopping GAPDH from moving into the nucleus, thus preventing the cell from dying.

Furthermore, they found that a natural derivative of salicylic acid from the Chinese medical herb licorice and a lab-synthesized derivative bind to GAPDH more tightly than salicylic acid. Both are more effective than salicylic acid at blocking GAPDH's movement into the nucleus and the resulting cell death."


Note, Red Vines isn't licorice.

 

[RodISHI]

Put a few fresh Willow leaves in your salad every day and avoid the processed versions. In the winter you can use a few twigs off of a Willow tree boiled in tea water for the same effect as aspirin.

If you make home made wine a few Willow leaves will also help kill the bacteria that causes the wine to sour and make vinegar.

 

[Delta4Embassy]

Put a few fresh Willow leaves in your salad every day and avoid the processed versions. In the winter you can use a few twigs off of a Willow tree boiled in tea water for the same effect as aspirin.

If you make home made wine a few Willow leaves will also help kill the bacteria that causes the wine to sour and make vinegar.

Prefer paying the buck for the bottle of aspirin.

 

[Iron Head]

I got a use for your aspiran. Take a bottle of them and shove them all individually up your dick hole in order to induce functional ER do that you are no longer equipped to hurt anybody.

 

[RodISHI]

Put a few fresh Willow leaves in your salad every day and avoid the processed versions. In the winter you can use a few twigs off of a Willow tree boiled in tea water for the same effect as aspirin.

If you make home made wine a few Willow leaves will also help kill the bacteria that causes the wine to sour and make vinegar.

Prefer paying the buck for the bottle of aspirin.

I prefer the added value of all of the goodies that God put into nature for us to use. Young tender leaves and shoots Willow leaves also are
a source for some of your vitamin C, a little Calcium in them too.
It can be used in homemade facial creams.
Boiled Willow bark liquid to use as a wash works well for personal hygiene, it is better than vinegar swoosh.
You can use all those leaves to help in a newly forming garden and even
make growth rooting hormones if you are a gardener from your Willows.

A nice blog that has the benefits of Willow and some of the uses. http://wildfoodsandmedicines.com/willow/

 

[Arianrhod]

Put a few fresh Willow leaves in your salad every day and avoid the processed versions. In the winter you can use a few twigs off of a Willow tree boiled in tea water for the same effect as aspirin.

If you make home made wine a few Willow leaves will also help kill the bacteria that causes the wine to sour and make vinegar.

Willow bark is also available as a supplement. Not everyone has a willow tree handy.

 

[shadow355]

http://medicalxpress.com/news/2015-11-breakdown-product-aspirin-blocks-cell.html

"A new study finds that a component of aspirin binds to an enzyme called GAPDH, which is believed to play a major role in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases.

Researchers at the Boyce Thompson Institute and John Hopkins University discovered that salicylic acid, the primary breakdown product of aspirin, binds to GAPDH, thereby stopping it from moving into a cell's nucleus, where it can trigger the cell's death. The study, which appears in the journal PLOS ONE, also suggests that derivatives of salicylic acid may hold promise for treating multiple neurodegenerative diseases.
...

The anti-Parkinson's drug deprenyl blocks GAPDH's entry into the nucleus and the resulting cell death. The researchers discovered that salicylic acid also is effective at stopping GAPDH from moving into the nucleus, thus preventing the cell from dying.

Furthermore, they found that a natural derivative of salicylic acid from the Chinese medical herb licorice and a lab-synthesized derivative bind to GAPDH more tightly than salicylic acid. Both are more effective than salicylic acid at blocking GAPDH's movement into the nucleus and the resulting cell death."


Note, Red Vines isn't licorice.

And the dosage of Aspirin to get these benefits is what ?

Would a small dose of aspirin, the current therapeutic level be not enough?

If not, a higher dose would be detrimental ....... Such as starting internal bleeding ?

Shadow 355

 

[waltky]

Granny takes a aspirin before she goes to bed at night...

Regular Aspirin Use May Lower Cancer Risk
March 03, 2016 - Aspirin therapy has long been recommended for some suffering from heart disease, but a new study indicates it could also help reduce the risk of certain cancers.

Writing in the journal JAMA Oncology, researchers from the Massachusetts General Hospital say aspirin therapy “significantly reduces the overall risk of cancer, a reduction that primarily reflects a lower risk of colorectal cancer and other tumors of the gastrointestinal tract.”

The findings, they say, could serve to complement types of cancer screening such as a colonoscopy. "We now can recommend that many individuals consider taking aspirin to reduce their risk of colorectal cancer - particularly those with other reasons for regular use, such as heart disease prevention - but we are not at a point where we can make a general recommendation for overall cancer prevention," said Andrew Chan, chief of the Clinical and Translational Epidemiology Unit in the Massachusetts General Hospital Division of Gastroenterology, the senior author of the report. "Our findings imply that aspirin use would be expected to prevent a significant number of colorectal cancers above and beyond those that would be prevented by screening and may have even greater benefit in settings in which the resources to devote to cancer screening are lacking," he said.

A new study claims regular aspirin use can reduce the chances of getting cancer.​

The researchers said other studies have pointed to a link between aspirin use and lowered risk for colorectal cancer, but that aspirin’s effect on other types of cancer is not fully understood. For the study, the researchers looked at 32 years of data collected from nearly 136,000 participants in the Nurse’s Health Study and Health Professionals Follow-up Study. They found that those who reported regular use of aspirin--taking a low or normal dose at least three times a week - lowered their chance of developing “any type” of cancer by 3 percent compared to those who did not take aspirin regularly. Those who took regular doses of aspirin had a 19 percent lower chance of developing colorectal cancer as well as a 15 percent reduction in chances of getting any gastrointestinal cancer.

This, researchers said, could lead to up to 30,000 fewer cases of gastrointestinal tumors in the U.S. and 7,500 fewer cases of colorectal cancer. "At this point, it would be very reasonable for individuals to discuss with their physicians the advisability of taking aspirin to prevent gastrointestinal cancer, particularly if they have risk factors such as a family history," said Chan. "But this should be done with the caveat that patients be well informed about the potential side effects of regular aspirin treatment and continue their regular screening tests. Furthermore, aspirin should not be viewed as a substitute for a colonoscopy or other cancer-screening tests."

Regular Aspirin Use May Lower Cancer Risk

 

[waltky]

Younger, Middle-aged adults experiencing rise in colon cancer...

Colorectal Cancer Rising Among Younger Adults
February 28, 2017 - Americans born in 1990 have double the risk of colon cancer and quadruple the risk of rectal cancer than those born around 1950, a new study suggests.

The study found that colorectal cancer is on the rise among young and middle-aged adults in their early 50s. Rectal cancer is growing particularly fast among people younger than 55, with 30 percent of diagnoses in people under 55. "Trends in young people are a bellwether for the future disease burden," said Rebecca Siegel, of the American Cancer Society and lead author of the study that appeared in the Journal of the National Cancer Institute. "Our finding that colorectal cancer risk for millennials has escalated back to the level of those born in the late 1800s is very sobering. Educational campaigns are needed to alert clinicians and the general public about this increase to help reduce delays in diagnosis, which are so prevalent in young people, but also to encourage healthier eating and more active lifestyles to try to reverse this trend."

Researchers note that rates of colorectal cancer have been falling since the 1980s with an even steeper decline in the past decade, which has been caused by more screening. But they wanted to find out why some studies have shown a rising rate among people under 50 for whom screening is generally not done. For their study, researchers looked at cases of colorectal cancer in people over 20 from 1974 to 2013. There were 490,305 cases.

Colon cancer is one of the world's deadliest diseases, but it often has no symptoms in the early stages. That's why doctors urge adults over 50 to have a colonoscopy to detect any possible cancer.​

The data showed the rates of colon cancer initially decreased after 1974, but then grew by one or two percent from the mid-1980s to 2013 among adults aged 20 to 39. For people aged 40 to 54, the rates increased between .5 percent and one percent from the mid 1990s to 2013. For rectal cancer, the increases were greater, with rates rising about three percent per year from 1974 to 2013 in adults aged 20 to 29. For adults between 30 and 39, there was a similar rise from 1980 to 2013. For adults between 40 and 54, rates increased by two percent from the 1990s to 2013.

Rates for adults older than 55 has been declining for about 40 years, researchers said. Researchers say the results could change the age at which screening for colorectal cancer starts and cite 10,400 cases diagnosed in people in their 40s plus 12,800 cases in people in their early 50s. "These numbers are similar to the total number of cervical cancers diagnosed, for which we recommend screening for the 95 million women ages 21 to 65 years," Siegel said.

Colorectal Cancer Rising Among Younger Adults

See also:

Study: Heroin Overdose Deaths Quadruple Between 2010-2015
February 24, 2017 - Deaths caused by heroin overdoses in the United States quadrupled between 2010 and 2015, according to a new report.

The National Center for Health Statistics says there were 12,989 overdose deaths involving heroin in 2015. In 2010, the number was 3,036. In percentages, heroin caused 8 percent of drug overdose deaths in 2010, and now it accounts for 25 percent. The center cites dropping prices and increasing potency for the rise in deaths.

A man injects himself with heroin using a needle obtained from the People's Harm Reduction Alliance, the nation's largest needle-exchange program, in Seattle, Washington.​

Furthermore, experts say they believe the opioid epidemic caused by prescription painkillers may also be driving people to use heroin as the drug is usually much cheaper. "You are 40 times more likely to use heroin if you started with opioid painkillers," Rich Hamburg, the executive vice president for the non-profit Trust for America’s Health, told the Reuters news agency. "Heroin is part of America's larger drug abuse problem."

Death from overdosing on prescription painkillers like oxycodone actually fell over the period of the study, dropping from 29 percent of all overdose deaths in 2010 to 24 percent in 2015. Overdoses deaths from cocaine also fell, albeit slightly, the study said. The states with the highest rates of overdose deaths in 2015 were West Virginia, New Hampshire, Kentucky and Ohio, the study found. Overdose deaths increased for all age groups, but rose the most among those 55 to 64, the study said.

Study: Heroin Overdose Deaths Quadruple Between 2010-2015

 

[waltky]

'Aspirin-a-day risky in old age'...

'Aspirin-a-day risky in old age' - major study
16 Sept.`18 - Elderly people in good health should not take an aspirin a day, according to a major study in the US and Australia.

There are proven benefits of the drug for people after a heart attack or stroke. But the trial found no benefit for healthy people over the age of 70, and the pills increased the risk of potentially fatal internal bleeding. Experts described the results as very important and cautioned against self-medicating with aspirin. People are prescribed aspirin after a heart attack or stroke because the drug thins the blood and reduces the chances of a repeat attack. Some completely healthy people also choose to take aspirin to reduce their risk and there is continuing research into whether the drug can be used to cut the risk of cancer. However, most research on the benefits of aspirin is performed on people in middle age and there is mounting evidence the dangers increase as we get older.

'No benefit'

The study was of 19,114 people in the US and Australia in good health, with no history of heart problems and over the age of 70. Half were given a daily low-dose aspirin for five years. Three reports in the New England Journal of Medicine showed the pills did not reduce their risk of heart problems or have any other benefits. They did increase the number of major stomach bleeds. Prof John McNeil, from Monash University, said: "It means millions of healthy older people around the world who are taking low dose aspirin without a medical reason, may be doing so unnecessarily, because the study showed no overall benefit to offset the risk of bleeding. "These findings will help inform prescribing doctors who have long been uncertain about whether to recommend aspirin to healthy patients."

Granny checkin' her supply o' aspirin​

The study also discovered an increase in deaths from cancer, although the researchers think this needs further investigation as it goes against current findings in the field. Prof Peter Rothwell, of Oxford University, a leading expert on the drug, said the findings were definitive. "Taking aspirin if you are otherwise healthy, over the age of 70, if you haven't had a previous heart attack or stroke, is really of very little benefit," he said. "And so self-medicating with aspirin in the absence of a definite medical indication isn't advisable." The findings do not apply to people taking aspirin because of a heart attack or stroke - they should continue to follow their doctor's advice. And anybody who has been taking low-dose aspirin for a long time is advised not to stop overnight as that may also cause problems. Instead they should discuss any concerns with their GP, says Prof Rothwell.

Daily aspirin 'risky in old age' - study