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Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting today in Science, a team led by researchers from the Broad Institute of MIT and Harvard, Brigham and Women's Hospital, and Harvard Medical School describes a new approach to prevent death in these essential kidney cells. Studying multiple animal models of kidney disease, the team discovered a compound that can impede loss of the filtration cells and restore kidney function. The work, inspired by an investigation into a genetic form of the condition, has the potential to affect therapeutic research for millions of people suffering from progressive kidney diseases.
"We're ultimately trying to create a drug that can protect these critical filtration cells in the kidney," said senior author Anna Greka, an institute member at Broad, associate physician at Brigham and Women's Hospital, and assistant professor at Harvard Medical School. "We attacked the problem from the biology of the genetic disease, and we think we've actually found what might be a shared pathway for kidney failure—and a potential way to treat it."
you think it might help the quality of life for young people also suffering from obesity, hypertension and diabetes?.............hey just asking....New compound stops progressive kidney disease in its tracks
December 7, 2017
Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting today in Science, a team led by researchers from the Broad Institute of MIT and Harvard, Brigham and Women's Hospital, and Harvard Medical School describes a new approach to prevent death in these essential kidney cells. Studying multiple animal models of kidney disease, the team discovered a compound that can impede loss of the filtration cells and restore kidney function. The work, inspired by an investigation into a genetic form of the condition, has the potential to affect therapeutic research for millions of people suffering from progressive kidney diseases.
"We're ultimately trying to create a drug that can protect these critical filtration cells in the kidney," said senior author Anna Greka, an institute member at Broad, associate physician at Brigham and Women's Hospital, and assistant professor at Harvard Medical School. "We attacked the problem from the biology of the genetic disease, and we think we've actually found what might be a shared pathway for kidney failure—and a potential way to treat it."
https://medicalxpres...ase-tracks.html
This is wonderful news! This would really help the quality of life in older people.
