We first recall that John Coltrane's Both Directions at Once, Giant Steps, and others, are classics in the evolution of saxophone virtuosity. The Lost Album John Coltrane’s majestic 1963 session, Both Directions at Once, is discovered As the article states, Coltrane died of liver cancer. Many do not know that the cancer was hepatitis B-induced hepatocellular carcinoma. Coltrane experimented in chord-stacking and other techniques that were well ahead of their time, Today it is possible to play the genes for hepatocellular carcinoma on the saxophone, which sequences challenge anyone who thinks they have a command over their instrument. This is an exercise in motor skills and decision making of which Coltrane was an adept, no doubt about it. In an amino acid approach (reminiscent of Coltrane's "Nature Boy"), Nature itself has already written the sheet music. To follow the sheet music of any living organism means to read and play its amino acid sequences. It is interesting that, unknown to us, not only was Coltrane's album being released (June 2018), amino acid saxophone was coming into being during these same weeks. As it progressed, a colleague mentioned to this writer the "Pi Piano" that can be seen and heard at youtube. This was a pleasant inspiration, because it showed that another human was working along these same lines. We note that the Pi approach has a limited range of ten digits, whereas the amino acid saxophone has a basic range of twenty amino acids which can be assigned to the keys of the instrument. In assigning the amino acids to the keys of the saxophone, we used the isoelectric points of amino acids, each one being unique. Arranging their pH values from high to low, we arrive at a template that can be used to read amino acid sequences, applied to such things as reading of important genes such as found in dyslexia, neurodegenerative diseases, cancer, etc.