The theory suggested that an organism's environment could modify the gemmules in any parts of the body, and that these modified gemmules would congregate in the reproductive organs of parents to be passed on to their offspring. Darwin's theory of
pangenesisgradually lost popularity in the 1890s when biologists increasingly abandoned the theory of inheritance of acquired characteristics (IAC), on which the
pangenesis theory partially relied. Around the turn of the twentieth century, biologists replaced the theory of
pangenesis with germ plasm theory and then with chromosomal theories of inheritance, and they replaced the concept of gemmules with that of
genes.
Pangenesis theory originated from the claim that characteristics acquired during an organism's life were heritable. A theory of inheritance of acquired characteristics (IAC) had persistent for almost two thousand years, since Greek antiquity