I don't know what you mean by "why only once".
There was one origin of life. A single unique event. I wonder why? And if only once in an environment we know is conducive to life then what does that say for the chances extraterrestially?
I don't think that's a mystery. In our solar system there is a sweet spot in which water can remain liquid without boiling away or freezing, and as far as we know, water is one of the necessary ingredients of life. It looks like Mars had it. And it's possible that it could exist on Europa and/or Enceladus. It would exist under hundreds of miles of ice but kept warm by the cores of those moons. So, in our solar system, there could be life on two or three globes, and Mars may have had it a billion or two years ago.
Of course, that's just our solar system, and there are estimated 100 billion trillion other solar systems in the universe in which there could be sweet spots, in which there could be life.
We don't know. Nor can we.
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