Right to try

[Manonthestreet]

An experimental pill has achieved the complete remission of cancer in 18 near-terminal patients with aggressive tumors that did not respond to treatments. The illness, acute myeloid leukemia, is the most common blood cancer in adults, accounting for 120,000 cases each year. The three-year survival rate is just 25%. The new drug, called revumenib, has completely eliminated cancer in a third of the participants in a long-awaited clinical study in the United States. Experimental pill achieves complete cancer remission in 18 people with aggressive leukemia
PAss it along if you know anyone suffering from this...

 

[badger2]

The target protein is called menin. Menin has two furin-like sites, so this will go into the coronavirus file:

Menin

UniProt

uniprot.org

'....337-340 'RNVR'....486-489 'RGPR.'

 

[badger2]

One of the reasons Baric's bat lab was growing coronaviruses in calu-3 lung cancer cells is because those particular cells prevent furin cleavage site mutations, linking this thread to post #2. Thus, it's only responsible that we connect Big Farmer's friend, the Jesuit Elf, and the Elf's institution to these cancer phenomena:

Dec 1997 NIH / Men1

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung - PubMed

Lung carcinoids occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). There are no well defined genetic abnormalities known to occur in these tumors. We studied 11 sporadic lung carcinoids for loss of heterozygosity (LOH) at the locus of the MEN1 gene on...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

The first suspicious thing noted is that on Uniprot's Men1 page, there are (no mutations [italics]) shown for the corresponding furin-like areas of the protein that we have posted in #2.