Powerful new oral painkiller blocks signals without sedation or addiction

[Hurricanelover]

Powerful new oral painkiller blocks signals without sedation or addiction
By Bronwyn Thompson
August 09, 2025

Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of addiction.

Researchers at Japan's Kyoto University Scientists have developed an oral medication that targets the α2B adrenoceptor, a little-studied brain receptor that scientists have found actually plays a major role in mechanical pain. This makes it the first-ever α2B-selective painkiller.

This receptor belongs in the adrenergic receptor family – α2A, α2B, α2C – but no approved drug has targeted a2B to inhibit the receptor with high precision. Existing drugs like dexmedetomidine target broad a2 receptors and in this example's case cause sedation and are not oral. This in itself makes this small-molecule drug candidate, also known as compound c545, a potentially new class of pain-relief drug.

"If successfully commercialized, ADRIANA would offer a new pain management option that does not rely on opioids, contributing significantly to the reduction of opioid use in clinical settings," said corresponding author Masatoshi Hagiwara, a specially-appointed professor at Kyoto University.

Powerful new oral painkiller blocks signals without sedation or addiction

Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of…

newatlas.com

This is so cool. Not being on opioids will save a lot of lives.

 

[wamose]

Powerful new oral painkiller blocks signals without sedation or addiction
By Bronwyn Thompson
August 09, 2025

Powerful new oral painkiller blocks signals without sedation or addiction

Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of…

newatlas.com

This is so cool. Not being on opioids will save a lot of lives.

I wonder if this drug could be used to help wean people off of opioids.

 

[luiza]

This is so cool. Not being on opioids will save a lot of lives.

If it is not ridiculed and " discredited" it will be a huge blow for Deep State and their Big Pharma arm for Control ---
Along with Education and Communication .

How this progresses will be a useful marker to show how WW3 is progressing .
That is
Old Style Deep State , versus Revised and Updated Deep State

 

[Muhammed]

Heroin was also marketed as being non-addictive.

 

[ReinyDays]

Powerful new oral painkiller blocks signals without sedation or addiction
By Bronwyn Thompson
August 09, 2025

Powerful new oral painkiller blocks signals without sedation or addiction

Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of…

newatlas.com

This is so cool. Not being on opioids will save a lot of lives.

Cheaper than providing medical service for the pain condition ... you must be invested in medical insurance companies ... ten dollars worth of pills instead of hundreds of thousands if not millions of dollars in diagnosis and treatment costs ...

That's how the opioid crisis happened ... pills are cheaper than cure ...

 

[braalian]

I’ll believe it when I see it