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- Aug 8, 2016
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This a 2019 US Air Force study. The study is rather long, but well worth the read in its entirety. I'm just gonna snip a bit from it, given what s going on at the moment. Emphasis added via bold fonts.
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Continued - Next Generation Bioweapons: Genetic Engineering and BW
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3) Gene Therapy as a Weapon: Gene therapy will revolutionize the treatment of human genetic diseases. The goal is to effect a permanent change in the genetic composition of a person by repairing or replacing a faulty gene. Genes have already been spliced into bacteria to produce ―human‖ insulin in large quantities. The eventual goal is to splice a gene that codes for the production of insulin into human pancreatic tissue to cure diabetes. Similar research is progressing on adding in the missing gene to prevent the symptoms of cystic fibrosis. However, the same technology could be subverted to insert pathogenic genes.
There are two general classes of gene therapy: germ-cell line (reproductive) and somatic cell line (therapeutic). Changes in DNA in germ cells would be inherited by future generations. Changes in DNA of somatic cells would affect only the individual and could not be passed on to descendants. Manipulation of somatic cells is subject to less ethical scrutiny than manipulation of germ cells.
This concept has already been used to alter the immunity of animals. The vaccinia virus (a poxvirus used to make immunization against smallpox) has been used as a vector to insert genes in mammalian cells. This genetically engineered virus has been used successfully to produce an oral vaccine to prevent rabies in wildlife.
Research for similar gene splicing in humans continues for possible vectors to carry the replacement genes to their targets. As has been done for animals, there is potential for human ―vaccination‖ against certain diseases, or as a targeted delivery capability for therapeutic drugs or cytotoxic effects.
One class of experimental vectors is the retroviruses which permanently integrate themselves into human chromosomes. HIV, which causes AIDS, is a retrovirus. So it should not be hard to understand that gene therapy might have sinister capability.
A viral vector has already produced a lethal strain of mousepox virus. The genetically manipulated virus completely suppressed the cell-mediated response (the arm of the immune system that combats viral infections) of the lab mice. Even mice previously vaccinated against the natural mousepox virus died within days of exposure to the super virus. Mousepox (which does not infect humans) and smallpox are related viruses. If smallpox were to be similarly genetically manipulated, our current vaccine may not protect against it. These vectors are not yet very efficient in introducing genes into tissue cells. But if a medical technique is perfected, similar vectors might eventually be used to insert harmful genes into an unsuspecting population.
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Techniques for cloning tissues and embryos continue to advance. Reproductive (germ-cell) cloning aims to implant a cloned embryo into a woman‘s uterus leading to the birth of a cloned baby. Therapeutic (somatic cell) cloning aims to use genes from a person‘s own cells to generate healthy tissue to treat a disease. For example, such cloning could be used to grow pancreatic cells to produce insulin to treat diabetes, or to grow nerve cells to repair damaged spinal cords. Already sheep, mice, swine, and cattle have been cloned. However, success (defined as births of live animals) rates are low. Initial cloning work with human embryos to produce omnipotent stem cells has been reported. Theoretically, the stem cells could in turn grow into virtually any cell type and serve as replacement tissue in diseases like diabetes. Researchers have also used a virus to insert a jellyfish gene into a rhesus monkey egg and produced the first genetically altered primate. The use of embryos and germ cells has raised many ethical questions.
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4) Stealth Viruses: The concept of a stealth virus is a cryptic viral infection that covertly enters human cells (genomes) and then remains dormant for an extended time. However, a signal by an external stimulus could later trigger the virus to activate and cause disease. This mechanism, in fact, occurs fairly commonly in nature. For example, many humans carry herpes virus which can activate to cause oral or genital lesions. Similarly, varicella virus will sometimes reactivate in the form of herpes zoster (shingles) in some people who had chicken pox earlier in life. However, the vast majority of viruses do not cause disease.
As a biological weapon, a stealth virus could clandestinely infect the genome of a population. Later, the virus could be activated in the targeted population, or a threat of activation could be used as blackmail.
Continued - Next Generation Bioweapons: Genetic Engineering and BW