excalibur
Diamond Member
- Mar 19, 2015
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This drug has no business getting a EUA.
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Molnupiravir Could Drive Escape Mutants
Molnupiravir’s mechanism of action — driving genetic mutations — is in itself problematic, given the already quickly mutating coronavirus spike protein. During Merck’s phase II trial, the SARS-CoV-2 spike protein exhibited 72 structural nucleotide changes, while the spike protein in the placebo group had only nine such changes.
The reality is, some of those changes could make the virus more infective, resistant to vaccines and treatments and unleash escape mutants into the environment.20 FDA panel member James Hildreth, president of Meharry Medical College in Tennessee, voted against authorizing molnupiravir for this reason.
He said, “Even if the probability is very low, 1 in 10,000 or 100,000, that this drug would induce an escape mutant which the vaccines we have do not cover, that would be catastrophic for the whole world.”21 William Haseltine, who founded and chaired the Division of Biochemical Pharmacology at Harvard, raised similar concerns in Forbes, stating:22
“My misgivings are founded on two key concerns. The first is the drug’s potential mutagenicity, and the possibility that its use could lead to birth defects or cancerous tumors. The second is a danger that is far greater and potentially far deadlier: the drug’s potential to supercharge SARS-CoV-2 mutations and unleash a more virulent variant upon the world.”
We’re Heading Toward a ‘World Class Disaster’
Haseltine explained that during prepandemic studies, molnupiravir was tested against pathogenic coronaviruses such as MERS-CoV. Not only were the coronaviruses able to become resistant to the drug, but the viruses continued to survive and replicate even with large numbers of mutations in every gene and protein.
...
Molnupiravir Could Drive Escape Mutants
Molnupiravir’s mechanism of action — driving genetic mutations — is in itself problematic, given the already quickly mutating coronavirus spike protein. During Merck’s phase II trial, the SARS-CoV-2 spike protein exhibited 72 structural nucleotide changes, while the spike protein in the placebo group had only nine such changes.
The reality is, some of those changes could make the virus more infective, resistant to vaccines and treatments and unleash escape mutants into the environment.20 FDA panel member James Hildreth, president of Meharry Medical College in Tennessee, voted against authorizing molnupiravir for this reason.
He said, “Even if the probability is very low, 1 in 10,000 or 100,000, that this drug would induce an escape mutant which the vaccines we have do not cover, that would be catastrophic for the whole world.”21 William Haseltine, who founded and chaired the Division of Biochemical Pharmacology at Harvard, raised similar concerns in Forbes, stating:22
“My misgivings are founded on two key concerns. The first is the drug’s potential mutagenicity, and the possibility that its use could lead to birth defects or cancerous tumors. The second is a danger that is far greater and potentially far deadlier: the drug’s potential to supercharge SARS-CoV-2 mutations and unleash a more virulent variant upon the world.”
We’re Heading Toward a ‘World Class Disaster’
Haseltine explained that during prepandemic studies, molnupiravir was tested against pathogenic coronaviruses such as MERS-CoV. Not only were the coronaviruses able to become resistant to the drug, but the viruses continued to survive and replicate even with large numbers of mutations in every gene and protein.
...
Merck’s New Covid Pill Is a Disaster
STORY AT-A-GLANCE An advisory panel to the U.S. Food and Drug Administration voted to grant emergency authorization to Merck’s oral
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