Well, since most of my blood relatives are toxic, I've gone for several years now with the "I just don't see them at all" method. In my book, your real family is the one you make for yourself. I make a nice, simple, stress-free turkey dinner at my house, with my husband and kids and friends, and give my mom and the other assorted toxics a call to wish them Happy Thanksgiving. Always works for me, and I've long since given up caring whether or not they're bothered by my unwillingness to be in their company.
This year could be a little unpleasant, since my daughter - who is an adult and is normally part of my toxic family's celebrations rather than mine - has asked if she can spend Thanksgiving with us, rather than going up to Phoenix with the others. I suspect, though, that since the house will be filled with my friends, most of whom she doesn't know, she'll be pretty subdued.