COVID-19’s Biological Politics

[badger2]

We’ll now link previous reports coming from communist China about virus-contaminated Norwegian salmon cutting boards:

Third Military Medical University, Chongqing, China:
A Human Monoclonal Antibody Potently Pan-Neutralizes SARS-CoV-2 VOCs by Targeting RBD Invariant Sites

https://www.biorx.org/content/10.1101/2021.11.29.470356v1.full.pdf

’....The epitope in RBD for antibody 35B5 is composed of 30 interacting residues....Y449....’

Chinook salmon bafinivirus spike is Y449, Atlantic salmon bafinivirus spike is Y449.

 

[badger2]

https://www.biorxiv.org/content/10.1101/2021.11.29.470356v1.full.pdf

 

[LordBrownTrout]

Back to that endothelial.....................

FAUCI ALERT — Cardiac Surgeon issues ‘acute coronary’ warning on mRNA vaccines…

New study and warning from Dr. Steven Gundry: mRNA vaccines dramatically increase risk of developing heart disease — “The PLUS Cardiac Test score has been measured every …

citizenfreepress.com

 

[badger2]

There

Back to that endothelial.....................

FAUCI ALERT — Cardiac Surgeon issues ‘acute coronary’ warning on mRNA vaccines…

New study and warning from Dr. Steven Gundry: mRNA vaccines dramatically increase risk of developing heart disease — “The PLUS Cardiac Test score has been measured every …

citizenfreepress.com

There are zero entries for ‘protein unstable lesion signature puls’ at Pubmed (National Library of Medicine). Therefore, this is an important abstract, above.

 

[badger2]

The drama continues. Here is the response to the abstract:

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001051

 

[LordBrownTrout]

https://www.biorxiv.org/content/10.1101/2021.11.29.470356v1.full.pdf

This is a good find about the 35B5.

 

[LordBrownTrout]

The drama continues. Here is the response to the abstract:

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001051

This abstract should be plastered on every news channel non stop for the next two weeks.

 

[badger2]

This

PULS Test (Protein Unstable Lesion Signature) - Noble Naturopathic

noblenaturopathic.com

‘....proteins that leak from cardiac lesions....’

These proteins in PULS are reminiscent of the post-vaccination cell’s forced production of Chinese commununist virus parts.

 

[badger2]

This abstract should be plastered on every news channel non stop for the next two weeks.

This should go on Skye’s thread right away.

 

[badger2]

PULS test includes ctack levels. Ctack links SARS-CoV-2 here:

Ctack / SARS-CoV-2

Blood Cytokine Analysis Suggests That SARS-CoV-2 Infection Results in a Sustained Tumour Promoting Environment in Cancer Patients - PubMed

Cytokines, chemokines, and (angiogenic) growth factors (CCGs) have been shown to play an intricate role in the progression of both solid and haematological malignancies. Recent studies have shown that SARS-CoV-2 infection leads to a worse outcome in cancer patients, especially in haematological...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

This is a good find about the 35B5.

This find may have come from another USMB poster though it doesn’t come up with a 35b5 search.

 

[badger2]

Further analysis of pre-Wuhan activity compares to porcine coronaviruses.
An Analysis of Hospital Traffic and Search Engine Data in Wuhan, China Indicates Early Disease Activity

https://dash.harvard.edu/bitstream/handle/1/42669767/Satellite_Images_Baidu_COVID19_manuscript_DASH.pdf?sequence=3&isAllowed=y

’....this finding lines up with the recent recognition that gastrointestinal (GI) symptoms are a unique feature of COVID-19 disease.’

 

[badger2]

Comparing porcine epidemic diarrhea virus with Omicron deletions @ positions 143-145, 69-60, and insertions @ position 214, the Ohio PEDV study suggests decreased severity:

PEDV, Ohio, 2014

New variant of porcine epidemic diarrhea virus, United States, 2014 - PubMed

New variant of porcine epidemic diarrhea virus, United States, 2014

pubmed.ncbi.nlm.nih.gov

’....It is highly possible that the sequence deletions, insertions and mutations found in variant strain OH851 might have contributed to the decreased severity of the clinical disease in piglets.’

 

[badger2]

We can document chloroquine’s use before Kennedy‘s hydroxychloroquine, who is incorrect about the chron, only going back to 2004. Health care workers may want to know about lysosomotrophic agents before the era of SARS-CoV. In his book, The Real Anthony Fauci, he documents the sabotage by the ego-tripping avarice of Big Pharma:

’The scientific literature first suggested that HCQ of CQ might be effective treatments for Coronavirus in 2004. In that era, following an outbreak, Chinese and Western governments were pouring millions of dollars into. An effort to identify existing a.k.a. “repurposed,” medicines that were effective against coronaviruses. With HCQ, they had stumbled across the Holy Grail. A CDC study published in 2005 in the Virology Journal, “Chloroquine is a Potent Inhibitor of SARS Coronavirus Infection and Spread” demonstrated that CQ quickly eliminated coronavirus in primate cell culture during the SARS outbreak. The study concludes, ‘We report....that chloroquine has strong antiviral effects on SARS-Coronairus infection of primate cells....[both] before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage.

This conclusion was particularly threatening to vaccine makers since it implies that chloroquine functions both as a preventive “vaccine” as well as a cure for SARS coronavirus. Common sense would presume it to be effective against other coronavirus strains. Worse still for Dr. Fauci and his vaccine-making friends, a NIAID study and a Dutch paper, both in 2014, confirmed chloroquine was effective against MERS — still another coronavirus.’
(Kennedy, The Real Anthony Fauci, p. 21 Efficacy Against Coronavirus with Early Intervention HCQ Protocol)

 

[eagle1462010]

We can document chloroquine’s use before Kennedy‘s hydroxychloroquine, who is incorrect about the chron, only going back to 2004. Health care workers may want to know about lysosomotrophic agents before the era of SARS-CoV. In his book, The Real Anthony Fauci, he documents the sabotage by the ego-tripping avarice of Big Pharma:

’The scientific literature first suggested that HCQ of CQ might be effective treatments for Coronavirus in 2004. In that era, following an outbreak, Chinese and Western governments were pouring millions of dollars into. An effort to identify existing a.k.a. “repurposed,” medicines that were effective against coronaviruses. With HCQ, they had stumbled across the Holy Grail. A CDC study published in 2005 in the Virology Journal, “Chloroquine is a Potent Inhibitor of SARS Coronavirus Infection and Spread” demonstrated that CQ quickly eliminated coronavirus in primate cell culture during the SARS outbreak. The study concludes, ‘We report....that chloroquine has strong antiviral effects on SARS-Coronairus infection of primate cells....[both] before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage.

This conclusion was particularly threatening to vaccine makers since it implies that chloroquine functions both as a preventive “vaccine” as well as a cure for SARS coronavirus. Common sense would presume it to be effective against other coronavirus strains. Worse still for Dr. Fauci and his vaccine-making friends, a NIAID study and a Dutch paper, both in 2014, confirmed chloroquine was effective against MERS — still another coronavirus.’
(Kennedy, The Real Anthony Fauci, p. 21 Efficacy Against Coronavirus with Early Intervention HCQ Protocol)

I have posted that study many times on these boards. Even when this first began.

 

[badger2]

Before going back to other pioneers of HCQ/CQ, against coronaviruses, mention should be made of Raoult and Zelenko, et al”

HCQ’s first prominent champion was Dr. Didier Raoult, the iconic French infectious disease professor, who has published more than 2,700 papers and is famous for having discovered 100 microorganisms, including the pathogen that causes Whipple’s Disease. On March 17, 2020, Dr. Raoult provided a preliminary report on 36 patients treated successfully with hydxroxychloroquine and sometimes azithromycin at his institution in Marseille.

In April, Dr. Vladimir (Zev) Zelenko, M.D., an upstate New York physician and early HCQ adopter, reproduced Dr. Didier Raoult’s “startling successes” by dramatically reducing expected mortalities among 800 patients Zelenko treated with the HCQ cocktail.

By late April of 2020, US doctors were widely prescribing HCQ to patients and family members, reporting outstanding results, and taking it themselves prophylactically.

In May 2020, Dr. Harvey Risch, M.D., Ph.D. published the most comprehensive study, to date, on HCQ’s efficacy against COVID. Risch is Yale University’s super-eminent Professor of Epidemiology, an illustrious world authority on the analysis of aggregate clinical data. Dr. Risch concluded that evidence is unequivocal for early and safe use of the HCQ cocktail. Dr. Risch published his work — a meta-analysis reviewing five outpatient studies — in affiliation with the Johns Hopkins Bloomberg School of Public Health in the American Journal of Epidemiology, under the urgent title, “Early Outpatient Treatment of Symptomatic, High-Risk COVID-19 Patients that Should be Ramped-Up Immediately as Key to Pandemic Crisis.”

He further demonstrated, with specificity, how HCQ’s critics — largely funded by Bill Gates and Dr. Tony Fauci — had misinterpreted, misstated, and misreported negative results by employing faulty protocols, most of which showed HCQ efficacy administered without zinc and Zithromax which were known to be helpful. But their main trick for ensuring the protocols failed was to wait until late in the disease process before administering HCQ — when it is known to be ineffective. Dr. Risch noted that evidence against HCQ used late in the course of the disease is irrelevant.

While acknowledging that Dr. Didier Raoult’s powerful French studies favoring HCQ efficacy were not randomized, Risch argued that the results were, nevertheless, so stunning as to far outweigh that deficit: “The first study of HCQ + AZ [....] showed a 50-fold benefit of HCQ + AZ vs. standard of care....This is such an enormous difference that it cannot be ignored despite a lack of randomization.” Risch has pointed out that the supposed need for randomized placebo-controlled trials is a shibboleth. In 2014 the Cochrane Collaboration proved in a landmark meta-analysis of 10,000 studies, that observational studies of the kind produced by Didier Raoult are equal in predictive ability ton randomized placebo-controlled trials. Furthermore, Risch observed that it is highly unethical to deny patients promising medications during a pandemic — particularly those which, like HCQ, have long-standing safety records.’
(Kennedy, The Real Anthony Fauci, p. 23)

 

[badger2]

I have posted that study many times on these boards. Even when this first began.

You posted the 2004 study?

 

[badger2]

Going further back in time, this study mentioning chloroquine against a coronavirus was first presented at the VIII International Symposium non Nidoviruses, Philadelphia, 20-25 May 2000:

Blau DM, Holmes KV, Human Coronavirus HCoV-229E Enters Susceptible Cells via the Endocytic Pathway
‘....There are two serotypes of human coronairus, HCoV-229E and HCoV-OC43....In order to infect susceptible cells, the S glycoprotein of HCoV-229E binds to its receptor, human aminopeptidase N (hAPN) also known as CD13, a metalloprotease. After attachment, the viral envelope must fuse with a cellular membrane....We have studied the entry of HCoV-229E into npolarized human colon carcinoma cells (Caco-2), and also show that the entry of HCoV-229E into MRC-5 human lung epithelial cells is inhibited bu drugs that block the acidification of endosomes.

These findings suggest that HCoV-229E undergoes endocytosis after binding to hAPN at the plasma membrane and the virion is then sorted into endosomes where fusion of viral envelope and endocytic membrane occur. If HCoV-229E enters by fusing with endocytic membranes, it is likely that these drugs will inhibit infection. Chloroquine, a weak base, and bafilomycin A1, a specific inhibitor of the vacuolar ATP-ase proton pump, both block acidification of endosomes. As seen in Table 2, treatment after viral replication has begun does not decrease the percent of cells expressing HCoV-229E antigen....It is thus possible that chloroquine and bafilomycin A1 affect not only the entry but also the release of the virus.

Incubation in chloroquine or bafilomycin A1 before and during virus inoculation resulted in a decrease in viral titers when compared to untreated, inoculated cells. In contrast, when the drugs were added 8-12 hours post-inoculation, there was no significant decease in viral yields compared to untreated, inoculated cells. These results show that lysosomotrophic drugs inhibit early at virus entry but at later times do not affect the release of virus.

Influenza hemagglutinin (HA), its viral attachment protein, undergoes a conformational change at the low pH found in endosomes. This change allows fusion of the viral envelope with the endosomal membrane.’

Where does this discovery of imprisoning the virus with weak bases like chloroquine and bafilomycin come from? One source is from poliovirus studies years before this report.

 

[badger2]

The chloroquine-poliovirus study was published on 1 Mar 1985, again showing that it imprisons the virus when applied in time:

Entry of Poliovirus Type 1 and Mouse Elberfeld (ME) Virus Into HEp-2 Cells: Receptor-Mediated Endocytosis and Endosomal or Lysosomal Uncoating

Entry of Poliovirus Type 1 and Mouse Elberfeld (ME) Virus into HEp-2 Cells: Receptor-mediated Endocytosis and Endosomal or Lysosomal Uncoating

SUMMARY Poliovirus type 1 appeared from electron microscope studies to enter HEp-2 cells by receptor-mediated endocytosis. On adsorption the virus was evently distributed over the cell surface, with some preference for the microvilli and their bases. Invagination of the cell surface membrane...

www.microbiologyresearch.org

’....By measuring viral RNA synthesis in vivo, we showed that the RNA of poliovirus and mouse Elberfeld (ME) virus was not released from endosomes and/or lysosomes into the cytoplasm when weak bases, chloroquine, NH4CL, or monensin were added. In the presence of both actinomycin D (for inhibition of cellular RNA synthesis) and one of the weak bases (added 0.5 h prior to infection), we measured the incorporation rate of [3H] uridine into newly synthesized viral RNA. It could be shown that viral RNA was progressively diminished by increasing concentrations of weak bases.

The inhibitory effect of weak bases was dependent on the time of addition....For strong inhibition the bases had to be added 0.5 h prior to infection or at least simultaneously with the viruses.’

 

[ClaireH]

We can document chloroquine’s use before Kennedy‘s hydroxychloroquine, who is incorrect about the chron, only going back to 2004. Health care workers may want to know about lysosomotrophic agents before the era of SARS-CoV. In his book, The Real Anthony Fauci, he documents the sabotage by the ego-tripping avarice of Big Pharma:

’The scientific literature first suggested that HCQ of CQ might be effective treatments for Coronavirus in 2004. In that era, following an outbreak, Chinese and Western governments were pouring millions of dollars into. An effort to identify existing a.k.a. “repurposed,” medicines that were effective against coronaviruses. With HCQ, they had stumbled across the Holy Grail. A CDC study published in 2005 in the Virology Journal, “Chloroquine is a Potent Inhibitor of SARS Coronavirus Infection and Spread” demonstrated that CQ quickly eliminated coronavirus in primate cell culture during the SARS outbreak. The study concludes, ‘We report....that chloroquine has strong antiviral effects on SARS-Coronairus infection of primate cells....[both] before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage.

This conclusion was particularly threatening to vaccine makers since it implies that chloroquine functions both as a preventive “vaccine” as well as a cure for SARS coronavirus. Common sense would presume it to be effective against other coronavirus strains. Worse still for Dr. Fauci and his vaccine-making friends, a NIAID study and a Dutch paper, both in 2014, confirmed chloroquine was effective against MERS — still another coronavirus.’
(Kennedy, The Real Anthony Fauci, p. 21 Efficacy Against Coronavirus with Early Intervention HCQ Protocol)

At the risk of adding a link pertaining to MERS that I’ve shared on another thread but in case reading prisoners haven’t reviewed it:

“Was NIH-funded work on MERS virus in China too risky? Science examines the controversy”

Science | AAAS

www.science.org