Bone-building discovery could transform osteoporosis treatment

[Hurricanelover]

Bone-building discovery could transform osteoporosis treatment
By Paul McClure
August 03, 2025

A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical force.

Osteoblasts are bone-forming cells. Osteoclasts, on the other hand, dissolve and break down (resorb) old or damaged bone cells, making room for osteoblasts to create new tissue in areas that are growing or in need of repair. Osteoporosis results from an imbalance between bone formation and bone resorption.

A new study led by the University of Leipzig in Germany has identified a critical regulator of bone formation, the G protein-coupled receptor 133 (GPR133), and a way to stimulate it – opening the door to a new strategy to treat or prevent osteoporosis.

Bone growth is, expectedly, most rapid during childhood and adolescence. Then it slows until our late twenties, when we usually reach peak bone mass. After this, bone density tends to plateau for a time before, generally after age 50, bone breakdown starts to exceed bone formation, gradually decreasing bone density as we age.

Bone-building discovery could transform osteoporosis treatment

A newly discovered receptor switch that boosts bone growth could transform how we treat osteoporosis, by stimulating the body’s own bone-building machinery using a targeted drug and even mechanical force.

newatlas.com

awesome...Good discovery that could help people deal with painful shit like esteoporosis.

 

[knuckles]

My genetics gives me thick bones, but this is good news for less robust types.